LEADER 00862nam0-2200325---450- 001 990010066170403321 005 20160426165928.0 020 $aIT$b803183 035 $a001006617 035 $aFED01001006617 035 $a(Aleph)001006617FED01 035 $a001006617 100 $a20160426d1978----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aDiscorso sul metodo$fCartesio$ga cura di Italo Cubeddu 210 $aRoma$cEditori riuniti$d1978 215 $a123 p.$d19 cm 225 1 $aˆLe ‰idee$v131 606 $aDescartes, Renè 676 $a194$v18 700 1$aDescartes,$bRené$f<1596-1650> 702 1$aCubeddu,$bItalo 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990010066170403321 952 $aP.1 6F DESC 29$bBIBL.2015/838$fFLFBC 959 $aFLFBC 997 $aUNINA LEADER 05670nam 2200721Ia 450 001 9910139034803321 005 20230803021420.0 010 $a1-118-81039-2 010 $a1-118-81040-6 010 $a1-118-81046-5 035 $a(CKB)2550000001108753 035 $a(EBL)1332529 035 $a(OCoLC)855019762 035 $a(SSID)ssj0000951533 035 $a(PQKBManifestationID)11572703 035 $a(PQKBTitleCode)TC0000951533 035 $a(PQKBWorkID)10885010 035 $a(PQKB)11036200 035 $a(MiAaPQ)EBC1332529 035 $a(Au-PeEL)EBL1332529 035 $a(CaPaEBR)ebr10740430 035 $a(CaONFJC)MIL508839 035 $a(EXLCZ)992550000001108753 100 $a20130603d2013 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiomimetics$b[electronic resource] $eadvancing nanobiomaterials and tissue engineering bonded systems /$fedited by Murugan Ramalingam, Xiumei Wang, Guoping Chen, Peter Ma, and Fu-Zhai Cui 210 $aHoboken, NJ $cJohn Wiley & Sons, Inc.$d2013 215 $a1 online resource (384 p.) 225 0 $aBiomedical science, engineering and technology 300 $aIncludes index. 311 $a1-118-46962-3 311 $a1-299-77588-8 327 $aCover; Title Page; Copyright Page; Contents; List of Contributors; Preface; Acknowledgements; 1 Biomimetic Polysaccharides and Derivatives for Cartilage Tissue Regeneration; 1.1 Introduction; 1.2 Strategies for Cartilage Tissue Engineering; 1.3 Designing Scaffold for Cartilage Tissue Engineering; 1.4 Natural Polysaccharides for Cartilage Tissue Engineering; 1.4.1 Chitin and Chitosan (CS)-based Materials; 1.4.2 HA-based Materials; 1.4.3 Alginate-based Materials; 1.4.4 Starch-based Materials; 1.4.5 Cellulose-based Materials; 1.5 Conclusions and Remarks on Prospects; References 327 $a2 Biomimetic Synthesis of Self-Assembled Mineralized Collagen-Based Composites for Bone Tissue Engineering 2.1 Introduction; 2.2 Hierarchical Assembly of Mineralized Collagen Fibrils in Natural Bone; 2.2.1 Panorama of Natural Bone; 2.2.1.1 Chemical Composition of Bone; 2.2.1.2 Hierarchical Organization of Natural Human Bone; 2.2.2 Self-Assembly of Mineralized Collagen Fibrils in Nature; 2.2.2.1 Collagen and Collagen Fibrils Array; 2.2.2.2 Structural Organization of Mineralized Collagen Fibrils; 2.2.2.3 Examples of Mineralized Collagen Fibrils in Natural Tissues 327 $a2.3 Biomimetic Synthesis of Self-Assembled Mineralized Fibrils 2.3.1 In Vitro Self-Assembly of Mineralized Collagen Fibrils; 2.3.2 In Vitro Self-Assembly of Mineralized Recombinant Collagen Fibrils; 2.3.3 In Vitro Self-Assembly of Mineralized Silk Fibroin Fibrils; 2.3.4 In Vitro Self-Assembly of Mineralized Peptide-Amphiphilic Nanofibers; 2.4 Applications of Mineralized Collagen-based Composites for Bone Regeneration; 2.4.1 Fabrication of Nano-HA/Collagen-based Composites; 2.4.1.1 Three-Dimensional Biomimetic Bone Scaffolds: Nano-HA/Collagen/PLA Composite (nHAC/PLA) 327 $a2.4.1.2 Injectable Bone Cement: Nano-HA/Collagen/Calcium Sulfate Hemihydrate (nHAC/CSH)2.4.2 Functional Improvements of Mineralized Collagen-based Composites; 2.4.3 Examples of Animal Models and Clinical Applications; 2.5 Concluding Remarks; References; 3 Biomimetic Mineralization of Hydrogel Biomaterials for Bone Tissue Engineering; 3.1 Introduction; 3.2 Incorporation of Inorganic Calcium Phosphate Nanoparticles into Hydrogels; 3.2.1 Inorganic Nanoparticles; 3.2.2 Hydrogel Composites Based on Natural Polymer Matrices; 3.2.3 Hydrogel Composites Based on Synthetic Polymer Matrices 327 $a3.3 Biomimetic Mineralization in Calcium and/or Phosphate-Containing Solutions 3.3.1 Soaking in Solutions Containing Calcium and Phosphate Ions; 3.3.2 In Situ Synthesis of Hydroxyapatite; 3.4 Enzymatically-Induced Mineralization Using Alkaline Phosphatase (ALP); 3.4.1 ALP-Induced Hydrogel Mineralization for Fundamental Research; 3.4.2 Enyzmatic Mineralization for Bone Regeneration Applications; 3.4.3 ALP Entrapment; 3.5 Enhancement of Hydrogel Mineralization Using Biomacromolecules; 3.5.1 Systems to Test Mineralization-Inducing Potential of Biomacromolecules 327 $a3.5.2 Biomacromolecule-Enhanced Mineralization for Bone Regeneration Applications 330 $aThis book compiles all aspects of biomimetics from fundamental principles to current technological advances and their future trends in the development of nanoscale biomaterials and tissue engineering. The scope of this book is principally confined to biologically-inspired design of materials and systems for the development of next generation nanobiomaterials and tissue engineering. The book addresses the state-of-the-art of research progress in the applications of the principles, processes, and techniques of biomimetics. The prospective outcomes of current advancements and challenges in bio 410 0$aBiomedical Science, Engineering, and Technology 606 $aBiomimetics 606 $aBiomedical materials 606 $aNanostructured materials 615 0$aBiomimetics. 615 0$aBiomedical materials. 615 0$aNanostructured materials. 676 $a610.28 701 $aRamalingam$b Murugan$0520713 701 $aWang$b Xiumei$c(Biomedical engineer)$0886685 701 $aChen$b Guoping$c(Biomedical engineer)$0886686 701 $aMa$b Peter X$0886687 701 $aCui$b Fu-Zhai$0886688 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139034803321 996 $aBiomimetics$91980073 997 $aUNINA