LEADER 01177nlm0 22003491i 450 001 990009814510403321 005 20140124162040.0 010 $a9780470172773$bonline 035 $a000981451 035 $aFED01000981451 035 $a(Aleph)000981451FED01 035 $a000981451 100 $a20140124d2006----km-y0itay0103----ba 101 0 $aeng 135 $adrnn-008mamaa 200 1 $aAnalysis and design of shallow and deep foundations$bRisorsa elettronica$fLymon C. Reese, William M. Isenhower, Shin-Tower Wang 210 $aHoboken, N. J.$cWiley$d2005 230 $aDocumento elettronico 306 $aPublished Online: 12 DEC 2007 336 $aTesto 337 $aFormato pdf 676 $a624.15 700 1$aReese,$bLymon C.$f<1917- >$0518353 702 1$aIsenhower,$bWilliam M. 702 1$aWang,$bShin-Tower 801 0$aIT$bUNINA$gREICAT$2UNIMARC 856 4 $zFull text per gli utenti Federico II$uhttp://onlinelibrary.wiley.com/book/10.1002/9780470172773 901 $aEB 912 $a990009814510403321 961 $aFoundations$aDesign and construction 996 $aAnalysis and design of shallow and deep foundations$9835315 997 $aUNINA LEADER 03818nam 2200625 450 001 9910137533203321 005 20230621135619.0 010 $a9782889195657 (ebook) 035 $a(CKB)3710000000569663 035 $a(SSID)ssj0001666247 035 $a(PQKBManifestationID)16455174 035 $a(PQKBTitleCode)TC0001666247 035 $a(PQKBWorkID)15000165 035 $a(PQKB)11743784 035 $a(WaSeSS)IndRDA00056289 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42835 035 $a(EXLCZ)993710000000569663 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCD4+ T cell differentiation in infection$b[electronic resource] $eamendments to the Th1/Th2 axiom /$fedited by Dragana Jankovic and Carl G. Feng 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (111 pages) $ccolour illustrations 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aCD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections. 606 $aClinical Immunology$2HILCC 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aInfection 610 $aDendritic Cells 610 $aCytokines 610 $aImmunoregulation 610 $aCD4 lymphocytes 610 $aMemory 610 $along noncoding RNA 610 $aMacrophages 610 $aMetabolism 610 $aTh1 Th2 615 7$aClinical Immunology 615 7$aMedicine 615 7$aHealth & Biological Sciences 700 $aCarl G Feng$4auth$01366255 702 $aFeng$b Carl G 702 $aJankovic$b Dragana 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137533203321 996 $aCD4+ T cell differentiation in infection$93388739 997 $aUNINA