LEADER 00772nam0-22002891--450- 001 990008410710403321 005 20061102121216.0 035 $a000841071 035 $aFED01000841071 035 $a(Aleph)000841071FED01 035 $a000841071 100 $a20061102d1957----km-y0itay50------ba 101 0 $aeng 102 $aUS 105 $ay-------001yy 200 1 $a<>history of the dollar$fArthur Nussbaum 210 $aNew York$cColumbia University press$d1957 215 $aVIII, 308 p.$d20 cm 676 $a332.4973 700 1$aNussbaum,$bArthur$0128181 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008410710403321 952 $aXV M 548$b56052$fFGBC 959 $aFGBC 996 $aHistory of the dollar$951160 997 $aUNINA LEADER 03071nam 2200433z- 450 001 9910220054503321 005 20210211 035 $a(CKB)3800000000216233 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40719 035 $a(oapen)doab40719 035 $a(EXLCZ)993800000000216233 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAlzheimer's Disease and the Fornix 210 $cFrontiers Media SA$d2016 215 $a1 online resource (110 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-959-2 330 $aThis e-book focuses primarily on the role of the fornix as a functional, prognostic, and diagnostic marker of Alzheimer's disease (AD), and the application of such a marker in clinical practice. Researchers have long been focused on the cortical pathology of AD, since the most important pathologic features are the senile plaques found in the cortex, and the neurofibrillary tangles and neuronal loss that start from the entorhinal cortex and the hippocampus. In addition to gray matter structures, histopathological studies indicate that the white matter is also altered in AD. The fornix is a white matter bundle that constitutes a core element of the limbic circuits, and is one of the most important anatomical structures related to memory. The fornices originate from the bilateral hippocampi, merge at the midline of the brain, again divide into the left and right side, and then into the precommissural and the postcommissural fibers, and terminate at the septal nuclei, nucleus accumbens (precommissural fornix), and hypothalamus (postcommissural fornix). These functional and anatomical features of the fornix have naturally captured researchers' attention as possible diagnostic and prognostic markers of AD. Growing evidence indicates that the alterations seen in the fornix are potentially a good marker with which to predict future conversion from mild cognitive impairment to AD, and even from a cognitively normal state to AD. The degree of alteration is correlated with the degree of memory impairment, indicating the potential for the use of the fornix as a functional marker. Moreover, there have been attempts to stimulate the fornix to recover the cognitive function lost with AD. Our goal is to provide information about the status of current research and to facilitate further scientific and clinical advancement in this topic. 606 $aNeurosciences$2bicssc 610 $aAlzheimer's disease 610 $aCognition 610 $aDiffusion Tensor Imaging 610 $aFornix 610 $aLimbic 610 $aMemory 610 $aMild Cognitive Impairment 610 $anormal aging 615 7$aNeurosciences 700 $aConstantine G. Lyketsos$4auth$01196274 702 $aKenichi Oishi$4auth 906 $aBOOK 912 $a9910220054503321 996 $aAlzheimer's Disease and the Fornix$93040934 997 $aUNINA