LEADER 00864nam0-22002771i-450- 001 990006982080403321 035 $a000698208 035 $aFED01000698208 035 $a(Aleph)000698208FED01 035 $a000698208 100 $a19990530d1925----km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aScrittori d'Italia$eopere scelte interpretate e inquadrate nella storia dell'estetica e della letteratura$fNatale Busetto 205 $a3.a ed. riv. 210 $aGenova$cAlighieri$d1925 215 $a440 p.$121 cm 327 $aVol. 3 parte 2: Il secondo ottocento e i contemporanei 700 1$aBusetto,$bNatale$f<1877-1968>$0179518 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006982080403321 952 $aBIB. BAT.4129(3)2$b$fBAT 959 $aBAT 996 $aScrittori d'Italia$9700849 997 $aUNINA LEADER 04883nam 2200781Ia 450 001 9910808327803321 005 20200520144314.0 010 $a9786613257765 010 $a9781283257763 010 $a1283257769 010 $a9781118067581 010 $a1118067584 010 $a9781118067598 010 $a1118067592 010 $a9781118067529 010 $a1118067525 035 $a(CKB)2550000000043383 035 $a(EBL)693185 035 $a(OCoLC)746324265 035 $a(SSID)ssj0000539765 035 $a(PQKBManifestationID)11357057 035 $a(PQKBTitleCode)TC0000539765 035 $a(PQKBWorkID)10571011 035 $a(PQKB)10249447 035 $a(MiAaPQ)EBC693185 035 $a(Au-PeEL)EBL693185 035 $a(CaPaEBR)ebr10510394 035 $a(CaONFJC)MIL325776 035 $a(PPN)243332866 035 $a(Perlego)1014267 035 $a(EXLCZ)992550000000043383 100 $a20110121d2011 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOral bioavailability $ebasic principles, advanced concepts, and applications /$fedited by Ming Hu, Xiaoling Li 205 $a1st ed. 210 $aHoboken, NJ $cJohn Wiley & Sons$dc2011 215 $a1 online resource (570 p.) 225 1 $aWiley series in drug discovery and development 300 $aDescription based upon print version of record. 311 08$a9780470260999 311 08$a0470260998 320 $aIncludes bibliographical references. 327 $aORAL BIOAVAILABILITY; CONTENTS; Foreword; Preface; Contributors; 1 Barriers to Oral Bioavailability-An Overview; 2 Physicochemical Characterization of Pharmaceutical Solids; 3 Solubility of Pharmaceutical Solids; 4 In Vitro Dissolution of Pharmaceutical Solids; 5 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption; 6 Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways; 7 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms; 8 Drug Metabolism in Gastrointestinal Tract 327 $a9 Efflux of Drugs via Transporters-The Antiabsorption Pathway 10 Liver Drug Metabolism; 11 Protein Binding of Drugs; 12 Urinary Excretion of Drugs and Drug Reabsorption; 13 Pharmacokinetic Behaviors of Orally Administered Drugs; 14 Effects of Food on Drug Absorption; 15 Drug-Drug Interactions and Drug-Dietary Chemical Interactions; 16 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans; 17 Amino Acid Drug Transporters; 18 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals 327 $a19 Organic Anion and Cation Drug Transporters 20 Gastric Retentive Drug Delivery Systems; 21 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems; 22 Prodrug Strategies to Enhance Oral Drug Absorption; 23 Oral Delivery of Protein/Peptide Therapeutics; 24 ABC Transporters in Intestinal and Liver Efflux; 25 Interplay Between Efflux Transporters and Metabolic Enzymes; 26 Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions; 27 Caco-2 Cell Culture Model for Oral Drug Absorption; 28 MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption 327 $a29 Intestinal Perfusion Methods for Oral Drug Absorptions 30 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion; 31 In vivo Methods for Oral Bioavailability Studies; 32 Determination of Regulation of Drug-Metabolizing Enzymes and Transporters; 33 Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction; Index 330 $aUnderstand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the a 410 0$aWiley series in drug discovery and development. 606 $aDrugs$xBioavailability 606 $aDrug development 606 $aIntestinal absorption 615 0$aDrugs$xBioavailability. 615 0$aDrug development. 615 0$aIntestinal absorption. 676 $a615/.19 701 $aHu$b Ming$cPh. D.$01629303 701 $aLi$b Xiaoling$f1957-$0505392 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808327803321 996 $aOral bioavailability$93966958 997 $aUNINA