LEADER 00777nam0-22003011i-450- 001 990006525540403321 005 20001010 035 $a000652554 035 $aFED01000652554 035 $a(Aleph)000652554FED01 035 $a000652554 100 $a20001010d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aTempo e lavoro$fOskar Negt 210 $aRoma$cEd. Lavoro$d1988. 215 $a216 p.$d21 cm 225 1 $aStudi e ricerche$v68 676 $a790.01 700 1$aNegt,$bOskar$0120514 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006525540403321 952 $aCOLLEZ. 848 (68)$b11124$fFSPBC 959 $aFSPBC 996 $aLebendige Arbeit, enteignete Zeit$939806 997 $aUNINA DB $aGEN01 LEADER 05392nam 2200649 450 001 9910460528603321 005 20200520144314.0 010 $a1-118-76868-X 010 $a1-118-76859-0 035 $a(CKB)3710000000446138 035 $a(EBL)1895592 035 $a(SSID)ssj0001515302 035 $a(PQKBManifestationID)11871998 035 $a(PQKBTitleCode)TC0001515302 035 $a(PQKBWorkID)11481568 035 $a(PQKB)10717689 035 $a(MiAaPQ)EBC1895592 035 $a(DLC) 2015008591 035 $a(Au-PeEL)EBL1895592 035 $a(CaPaEBR)ebr11078110 035 $a(CaONFJC)MIL814347 035 $a(OCoLC)904400112 035 $a(EXLCZ)993710000000446138 100 $a20150725h20152015 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGeneral and molecular pharmacology $eprinciples of drug action /$fedited by Francesco Clementi [and six others] 210 1$aHoboken, New Jersey :$cWiley,$d2015. 210 4$dİ2015 215 $a1 online resource (2938 p.) 300 $aDescription based upon print version of record. 311 $a1-118-76857-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCOVER; TABLE OF CONTENTS; TITLE PAGE; LIST OF CONTRIBUTORS; PREFACE; SECTION 1: INTRODUCTION TO PHARMACOLOGY; 1 ESSENTIAL LEXICON OF PHARMACOLOGY; THE SOCIAL IMPACT OF PHARMACOLOGY; ESSENTIAL LEXICON; TAKE-HOME MESSAGE; 2 A SHORT HISTORY OF PHARMACOLOGY; BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY; MODERN PHARMACOLOGY; THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM; TAKE-HOME MESSAGE; FURTHER READING; SECTION 2: GETTING THE DRUG TO ITS SITE OF ACTION; 3 CELLULAR BASIS OF PHARMACOKINETICS; A QUICK JOURNEY WITH THE DRUG IN THE BODY; CROSSING CELL MEMBRANES 327 $aDRUG DIFFUSION TO ORGANS AND TISSUES TAKE-HOME MESSAGE; FURTHER READING; 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES; GENERAL RULES ABOUT DRUG ABSORPTION RATE; ENTERAL ROUTES OF ADMINISTRATION; SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION; OTHER ROUTES OF DRUG ADMINISTRATION; ABSORPTION KINETICS; TAKE-HOME MESSAGE; FURTHER READING; 5 DRUG DISTRIBUTION AND ELIMINATION; DISTRIBUTION; ELIMINATION; RENAL EXCRETION OF DRUGS; HEPATIC EXCRETION AND ENTEROHEPATIC CYCLE; TAKE-HOME MESSAGE; FURTHER READING; 6 DRUG METABOLISM; METABOLIC MODIFICATION OF DRUG ACTIVITY; TWO PHASES OF DRUG METABOLISM 327 $aEXTRAHEPATIC BIOTRANSFORMATIONS PHARMACOMETABOLIC INDUCTION AND INHIBITION; TAKE-HOME MESSAGE; FURTHER READING; 7 CONTROL OF DRUG PLASMA CONCENTRATION; TIME COURSE OF DRUG PLASMA CONCENTRATION FOLLOWING A SINGLE ADMINISTRATION; DRUGS DISTRIBUTE TO ORGANS AND TISSUES AND THEN ARE ELIMINATED; DRUG PLASMA CONCENTRATION TIME COURSE DURING REPETITIVE ADMINISTRATIONS; MULTICOMPARTMENTAL KINETICS; CORRECTIONS OF THE THERAPEUTIC REGIMEN; TAKE-HOME MESSAGE; FURTHER READING; SECTION 3: RECEPTORS AND SIGNAL TRANSDUCTION; 8 DRUG-RECEPTOR INTERACTIONS: QUANTITATIVE AND QUALITATIVE ASPECTS 327 $aGENERAL PROPERTIES OF DRUG RECEPTORS CHARACTERISTICS OF DRUG-RECEPTOR INTERACTION; QUANTITATIVE ASPECTS OF DRUG EFFECTS: DOSE-RESPONSE CURVES; FROM DRUG-RECEPTOR INTERACTION TO DRUG RESPONSE; TAKE-HOME MESSAGE; FURTHER READING; 9 RECEPTORS AND MODULATION OF THEIR RESPONSE; CLASSES OF RECEPTORS AND STRATEGIES OF SIGNAL TRANSDUCTION; CONTROL OF RECEPTOR LOCALIZATION IN THE CELL MEMBRANE; INTRACELLULAR TRAFFIC OF CELL RECEPTORS; MODULATION OF RECEPTOR RESPONSES; RECEPTOR MODULATION BY DRUGS; TAKE-HOME MESSAGE; FURTHER READING; 10 ADAPTATION TO DRUG RESPONSE AND DRUG DEPENDENCE 327 $aMOLECULAR, CELLULAR, AND SYSTEMIC ADAPTATION DRUG ADDICTION AS A PARADIGM OF ALLOSTATIC ADAPTATION; THERAPY FOR DRUG DEPENDENCE; TAKE-HOME MESSAGE; FURTHER READING; 11 PHARMACOLOGICAL MODULATION OF POSTTRANSLATIONAL MODIFICATIONS; PROTEIN PHOSPHORYLATION; SUMOylation; UBIQUITINATION; GLYCOSYLATION; ACETYLATION; HYDROXYLATION; CARBOXYLATION; METHYLATION; S-NITROSYLATION; DISULFIDE BONDS; LIPID MODIFICATIONS; PHARMACOLOGICAL MODULATION OF POST TRANSLATIONAL MODIFICATIONS; TAKE-HOME MESSAGE; FURTHER READING; 12 CALCIUM HOMEOSTASIS WITHIN THE CELLS; THE CYTOSOL: A CROSSROAD OF Ca2+ FLUXES 327 $aTHE PLASMA MEMBRANE: CHANNELS, PUMPS, AND TRANSPORTERS 330 $aWith a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students Discusses the relevance of pharmacokinetics and drug development 606 $aPharmaceutical chemistry 606 $aMolecular biology 608 $aElectronic books. 615 0$aPharmaceutical chemistry. 615 0$aMolecular biology. 676 $a615.1/9 702 $aClementi$b Francesco 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910460528603321 996 $aGeneral and molecular pharmacology$91566564 997 $aUNINA