LEADER 00800nam0-22002771i-450- 001 990006237360403321 005 19980601 035 $a000623736 035 $aFED01000623736 035 $a(Aleph)000623736FED01 035 $a000623736 100 $a19980601d1852----km-y0itay50------ba 105 $a--------00-yy 200 1 $a<>Aufgabender Staatsgessalt und ihre Grenzen$fViktor Cathrein. 210 $aFreiburg im Breisgau$cHerder'schen Verlagshandlung$d1852 215 $aIV,, 149 p.$d24 cm 676 $a342 700 1$aCathrein,$bViktor$0225658 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006237360403321 952 $aI C 93$b22973$fFGBC 959 $aFGBC 996 $aAufgabender Staatsgessalt und ihre Grenzen$9636483 997 $aUNINA DB $aGIU01 LEADER 04280nam 2200973z- 450 001 9910557376503321 005 20220111 035 $a(CKB)5400000000042125 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77144 035 $a(oapen)doab77144 035 $a(EXLCZ)995400000000042125 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aExploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (313 p.) 311 08$a3-0365-2677-3 311 08$a3-0365-2676-5 330 $aGlycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled "Exploring the multifaceted roles of glycosaminoglycans (GAGs)-new advances and further challenges", features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide.A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting "omics" fields. 517 $aExploring the Multifaceted Roles of Glycosaminoglycans 606 $aBiology, life sciences$2bicssc 606 $aResearch and information: general$2bicssc 610 $a(chemical, 610 $a(Sulfate) 610 $a& 610 $a3D 610 $aAcid, 610 $aand 610 $aas 610 $abiomaterials 610 $aBiosynthesis 610 $aCharacterization 610 $aChondroitin 610 $acomplexes 610 $adegree 610 $aDermatan 610 $adisease 610 $aengineering,...) 610 $aExtracellular 610 $aExtraction 610 $aGAG 610 $aGAG-based 610 $aGAGs 610 $aGAGs: 610 $aGlycobiology 610 $aHeparan 610 $aHeparin, 610 $aHeparosan 610 $aHyaluronic 610 $ain 610 $aKeratan, 610 $alike 610 $aMatrix 610 $ametabolic 610 $amolecular 610 $ananocarriers 610 $aof 610 $aoligosaccharides 610 $aPeri 610 $apolymerization, 610 $aProtein-GAG 610 $aRegulation 610 $arelationship 610 $arelationships 610 $asequence 610 $astructure/function 610 $astructure/properties 610 $astructures,....) 610 $aSynthesis 610 $aweight, 615 7$aBiology, life sciences 615 7$aResearch and information: general 700 $aNikitovic$b Dragana$4edt$01325180 702 $aPerez$b Serge$4edt 702 $aNikitovic$b Dragana$4oth 702 $aPerez$b Serge$4oth 906 $aBOOK 912 $a9910557376503321 996 $aExploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges$93036651 997 $aUNINA