LEADER 00830nam0-22002771i-450- 001 990005663610403321 005 20080215113229.0 010 $a3-534-10230-4 035 $a000566361 035 $aFED01000566361 035 $a(Aleph)000566361FED01 035 $a000566361 100 $a19990604d1989----km-y0itay50------ba 101 0 $ager 105 $ay-------001yy 200 1 $a<>transzendentale Denken des deutschen Idealismus$fJoachim Kopper 210 $aDarmstadt$cWissenschaftliche Buchgesellschaft$dc1989 215 $aXI, 257 p.$d20 cm 700 1$aKopper,$bJoachim$0142598 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990005663610403321 952 $aP.1 FG 1060$bBIBL. 9502$fFLFBC 959 $aFLFBC 996 $aTranszendentale Denken des deutschen Idealismus$9600508 997 $aUNINA LEADER 03987nam 2200649 a 450 001 9910964256303321 005 20251017110119.0 010 $a0-309-21224-3 010 $a1-283-21345-1 010 $a9786613213457 010 $a0-309-21222-7 035 $a(CKB)2550000000043073 035 $a(EBL)3378800 035 $a(SSID)ssj0000537170 035 $a(PQKBManifestationID)11352570 035 $a(PQKBTitleCode)TC0000537170 035 $a(PQKBWorkID)10553842 035 $a(PQKB)11052430 035 $a(MiAaPQ)EBC3378800 035 $a(Au-PeEL)EBL3378800 035 $a(CaPaEBR)ebr10488621 035 $a(CaONFJC)MIL321345 035 $a(OCoLC)923283605 035 $a(DNLM)1571253 035 $a(EXLCZ)992550000000043073 100 $a20110827d2011 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGlutamate-related biomarkers in drug development for disorders of the nervous system $eworkshop summary /$fDiana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board of Population Health and Public Health Practice, Institute of Medicine of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$d2011 215 $a1 online resource (74 p.) 300 $aDescription based upon print version of record. 311 08$a0-309-21221-9 320 $aIncludes bibliographical references and index. 327 $a""Front Matter""; ""Reviewers""; ""Contents""; ""1 Introduction""; ""2 Overview of the Glutamatergic System""; ""3 Glutamate Biomarkers""; ""4 Treatment Implications of Biomarkers""; ""5 Challenges and Opportunities""; ""Appendix A: References""; ""Appendix B: Registered Attendees""; ""Appendix C: Agenda"" 330 $aGlutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop. 606 $aGlutamic acid$xPharmacokinetics 606 $aCentral nervous system$xDiseases 615 0$aGlutamic acid$xPharmacokinetics. 615 0$aCentral nervous system$xDiseases. 676 $a616.8061 701 $aPankevich$b Diana E$01851817 701 $aDavis$b Miriam$0856948 701 $aAltevogt$b Bruce M$01791694 712 02$aInstitute of Medicine (U.S.).$bForum on Neuroscience and Nervous System Disorders. 712 02$aInstitute of Medicine (U.S.).$bBoard of Population Health and Public Health Practice. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910964256303321 996 $aGlutamate-related biomarkers in drug development for disorders of the nervous system$94446140 997 $aUNINA