LEADER 00882nam0-22003011i-450- 001 990005009790403321 005 20071002114520.0 035 $a000500979 035 $aFED01000500979 035 $a(Aleph)000500979FED01 035 $a000500979 100 $a19990604g19679999km-y0itay50------ba 101 0 $ager 105 $ay-------001yy 200 1 $aMusica romana$eDie Bedeutung der Musik im Leben der Römer$fvon Günther Wille 210 $aAmsterdam$cVerlag P. Schippers N.V.$d1967 215 $a799 p.$d26 cm 610 0 $aMusica$aRoma antica$aStoria 676 $a780.937$v21$zita 700 1$aWille,$bGünther$0385394 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990005009790403321 952 $aXII 38$bBibl. 43.753$fFLFBC 952 $a780.9 WIL 1$bBIBL.5136$fFLFBC 959 $aFLFBC 996 $aMusica romana$9529858 997 $aUNINA LEADER 03286nam 22005055 450 001 9910338254103321 005 20250504234936.0 010 $a4-431-55585-4 024 7 $a10.1007/978-4-431-55585-8 035 $a(CKB)4100000008280486 035 $a(MiAaPQ)EBC5780061 035 $a(DE-He213)978-4-431-55585-8 035 $a(PPN)236520989 035 $a(EXLCZ)994100000008280486 100 $a20190521d2019 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDose-Finding Designs for Early-Phase Cancer Clinical Trials $eA Brief Guidebook to Theory and Practice /$fby Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui 205 $a1st ed. 2019. 210 1$aTokyo :$cSpringer Japan :$cImprint: Springer,$d2019. 215 $a1 online resource (146 pages) 225 1 $aJSS Research Series in Statistics,$x2364-0065 311 08$a4-431-55584-6 327 $a1. Introduction -- 2. Dose Finding in Early Phase Clinical Trials -- 3. Rule -- Based Designs -- 4. Continual Reassessment Method Designs -- 5. Escalation with Overdose Control Designs -- 6. Decision -- Theoretic Designs -- 7. Complex Designs. 330 $aThis book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This bookalso covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on. 410 0$aJSS Research Series in Statistics,$x2364-0065 606 $aBiometry 606 $aStatistics 606 $aBiostatistics 606 $aStatistical Theory and Methods 615 0$aBiometry. 615 0$aStatistics. 615 14$aBiostatistics. 615 24$aStatistical Theory and Methods. 676 $a610.724 700 $aDaimon$b Takashi$4aut$4http://id.loc.gov/vocabulary/relators/aut$0781818 702 $aHirakawa$b Akihiro$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aMatsui$b Shigeyuki$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910338254103321 996 $aDose-Finding Designs for Early-Phase Cancer Clinical Trials$92517018 997 $aUNINA