LEADER 01069cam0-22003851i-450- 001 990003855110403321 005 20090401122308.0 035 $a000385511 035 $aFED01000385511 035 $a(Aleph)000385511FED01 035 $a000385511 100 $a20030910d1971----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $a<>agricoltura negli statuti regionali$fa cura di Giorgio Pastori e di Roberto Ruffilli 210 $aBologna$cil Mulino$d1971 215 $a100 p.$d21 cm 225 1 $aAgricoltura e regioni$v3 610 0 $aAgricoltura$aItalia 610 0 $aRegioni$aItalia 676 $a353.824 702 1$aPastori,$bGiorgio 702 1$aRuffilli,$bRoberto 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003855110403321 952 $aH/1.14 AGR/71$b7030/I$fSES 952 $aI I 55 (3)$b98134$fFGBC 952 $aDPR 35-63/1$b6198$fDEC 959 $aSES 959 $aFGBC 959 $aDEC 996 $aAgricoltura negli statuti regionali$9514855 997 $aUNINA LEADER 02247nam 2200457z- 450 001 9910220055103321 005 20210212 035 $a(CKB)3800000000216227 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/62680 035 $a(oapen)doab62680 035 $a(EXLCZ)993800000000216227 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aWhy vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens 210 $cFrontiers Media SA$d2016 215 $a1 online resource (157 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-966-5 330 $aDespite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens. 606 $aMedicine$2bicssc 610 $aGenetics 610 $aHCV 610 $aHIV 610 $aimmunology 610 $aInfectious Disease 610 $ainfluenza 610 $aMalaria 610 $aVaccine 615 7$aMedicine 700 $aMagdalena Plebanski$4auth$01296310 702 $aEric J. Gowans$4auth 702 $aPeter Smooker$4auth 702 $aShuo Li$4auth 906 $aBOOK 912 $a9910220055103321 996 $aWhy vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens$93023985 997 $aUNINA