LEADER 03226nam 2200577 a 450 001 9910437826303321 005 20200520144314.0 010 $a3-642-37765-3 024 7 $a10.1007/978-3-642-37765-5 035 $a(CKB)2670000000371225 035 $a(EBL)1317009 035 $a(SSID)ssj0000894398 035 $a(PQKBManifestationID)11472553 035 $a(PQKBTitleCode)TC0000894398 035 $a(PQKBWorkID)10834892 035 $a(PQKB)10091614 035 $a(DE-He213)978-3-642-37765-5 035 $a(MiAaPQ)EBC1317009 035 $a(PPN)170491633 035 $a(EXLCZ)992670000000371225 100 $a20130424d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIntrinsic immunity /$fBryan R. Cullen, editor ; responsible series editor, Peter K. Vogt 205 $a1st ed. 2013. 210 $aHeidelberg ;$aNew York $cSpringer$dc2013 215 $a1 online resource (264 p.) 225 1 $aCurrent topics in microbiology and immunology,$x0070-217X ;$vv. 371 300 $aDescription based upon print version of record. 311 $a3-642-42763-4 311 $a3-642-37764-5 320 $aIncludes bibliographical references and index. 327 $aThe APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response. 330 $aRecent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.  . 410 0$aCurrent topics in microbiology and immunology ;$vv. 371. 606 $aImmunity 615 0$aImmunity. 676 $a571.9/648 676 $a616.079 701 $aCullen$b Bryan R$01754792 701 $aVogt$b Peter K$075916 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437826303321 996 $aIntrinsic immunity$94191289 997 $aUNINA LEADER 01374cam0-22004571i-450 001 990003126320403321 005 20250402140304.0 035 $a000312632 035 $aFED01000312632 035 $a(Aleph)000312632FED01 035 $a000312632 100 $a20030910d1977----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aMatematica per le scienze economiche e statistiche$fGiulio Cesare Barozzi, Corrado Corradi 210 $aBologna$cil Mulino$d1977 215 $a736 p.$d21 cm 225 1 $aCollezione di testi e di studi$iEconomia 610 0 $aStatistica$aMetodi matematici 676 $a330.1$v18$zita 700 1$aBarozzi,$bGiulio Cesare$f<1936- >$0333793 701 1$aCorradi,$bCorrado$f<1945- >$089588 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a990003126320403321 952 $aISVE CO.6$fDECTS 952 $aFondo Cupo 74$b02/0074/25$fFAGBC 952 $aC0.32$b6999$fDECTS 952 $aVI A 234$b19287$fFSPBC 952 $aB/3.0 BAR.1$b10079/I a$fSES 952 $aB/3.0 BAR.2$b10079/I b$fSES 952 $aB/3.0 BAR.3$b10079/I c$fSES 952 $aZIT-018$b22415$fMA1 959 $aDECTS 959 $aSES 959 $aFSPBC 959 $aMA1 959 $aFAGBC 996 $aMatematica per le scienze economiche e statistiche$9456444 997 $aUNINA LEADER 00974nam a2200277 i 4500 001 991003968839707536 005 20250507103239.0 008 000229s1993 it er 001 0 ita 020 $a8806132377 035 $ab11241925-39ule_inst 035 $aPARLA192350$9ExL 040 $aDip.to Scienze dell'Antichità$bita$dSocioculturale Scs 041 1 $aita$hgrc 100 0 $aAristophanes$0602827 245 10$aPace; Uccelli /$cAristofane ; a cura di Raffaele Cantarella 260 $aTorino :$bEinaudi,$cc1993 300 $aXXIV, 133 p. ;$c18 cm 490 1 $aCollezione di teatro ;$v345 500 $aTrad. italiana 700 1 $aCantarella, Raffaele 907 $a.b11241925$b23-02-17$c01-07-02 912 $a991003968839707536 945 $aLE007 880.1 Aristophanes CAN 01.05$g1$i2015000046055$lle007$o-$pE0.00$q-$rl$s-$t0$u2$v0$w2$x0$y.i11400419$z01-07-02 996 $aPace; Uccelli$93369105 997 $aUNISALENTO 998 $ale007$b01-01-00$cm$da$e-$fita$git$h0$i1