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Rawlings, Guy Salvesen 205 $a3rd ed. 210 $aOxford $cAcademic$d2012 215 $a1 online resource (3987 p.) 300 $aPrevious ed.: London: Elsevier Academic, 2004. 311 $a0-12-382219-X 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Handbook of Proteolytic Enzymes; Copyright Page; Contents; Editor Biographies; Contributors; Preface; Introduction; Terminology; Organization of the Handbook; Special forms of information in the Handbook; Links to the MEROPS database; Molecular images; Alignments; Secondary structure; Description of substrate specificity; References; Aspartic Peptidases; 1 Introduction: Aspartic and Glutamic Peptidases and Their Clans; Clan AA; Family A1; Other Families in Clan AA; Clan AF; Clan AC; Clan AD; Clan AE; Other Families; Glutamic Peptidases; Asparagine Peptide Lyases 327 $aClans NA, NC and NEInteins; Autotransporters; References; 2 Catalytic Pathways of Aspartic Peptidases; Introduction; Enzymatic Mechanism of Aspartic Peptidases; Enzymatic Mechanism of Glutamic Peptidases; References; 3 Pepsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Pepsinogen; Preparation; Biological Aspects; Related Peptidases; Further Reading; References; 4 Pepsin B; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Further Reading; References; 5 Chymosin; Databanks; Name and History 327 $aActivity and SpecificityStructural Chemistry; Preparation; Biological Aspects; Distinguishing Features; Related Proteinases; Further Reading; References; 6 Cathepsin E; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects; Tissue Distribution and Subcellular Localization; Regulation of Gene Expression; Processing, Maturation and Intracellular Trafficking Of Cathepsin E; Physiological Roles of Cathepsin E; Distinguishing Features; Further Reading; References; 7 Gastricsin; Databanks; Name and History; Activity and Specificity 327 $aStructural ChemistryProgastricsin; Preparation; Biological Aspects; References; 8 Cathepsin D; Databanks; Name and History; Activity and Specificity; Assay Methods; Specificity; Inhibition and Activation; Structural Chemistry; Three-dimensional Structure; Preparation; Biological Aspects; Gene and Expression Control; Knock-out Model; Organ Distribution and Cellular Localization; Apoptosis; Involvement in Cancer; Neurodegeneration; Other Biological Functions; Distinguishing Features; Related Peptidases; Acknowledgment; Further Reading; References; 9 Nothepsin; Databanks; Name and History 327 $aActivity and SpecificityStructural Chemistry; Primary Structure Analysis; Distinguishing Features of This New Class of Aspartic Proteinases; Retrieval and Sequencing of Nothepsin Enzymes; Presence of a Nothepsin Enzyme in Non-Antarctic Fish; Nothepsin in Organisms Other Than Fish; Preparation; Biological Aspects; Expression Pattern of the Nothepsin in Fish and Lizard; Phylogenetic Analysis, Adaptive Evolution and Role of Nothepsin; Further Reading; References; 10 Napsin A; Databanks; Name and History; Activity and Specificity; Structural Chemistry; Preparation; Biological Aspects 327 $aFurther Reading 330 $aThe third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. 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