LEADER 00910nam0-22003011i-450 001 990001768690403321 005 20190529131417.0 035 $a000176869 035 $aFED01000176869 035 $a(Aleph)000176869FED01 035 $a000176869 100 $a20030910d1965----km-y0itay50------ba 101 0 $aita 200 1 $aCromatografia su strati sottili di amido$eI-Controllo dell'attivitą dell'adsorbente$fC. Calzolari, L. Favretto, G. Bruni 210 $aUdine$cEd. Del Bianco$d1965 215 $a23 p.$d24 cm 610 0 $aMerceologia 676 $a660 700 1$aCalzolari,$bClaudio$068564 701 1$aBruni,$bGianna$0356144 701 1$aFavretto,$bLuciano$076887 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aLG 912 $a990001768690403321 952 $a60 OP. 67/22$b40985$fFAGBC 959 $aFAGBC 996 $aCromatografia su strati sottili di amido$9363994 997 $aUNINA LEADER 02685nam 2200481z- 450 001 9910220038903321 005 20251127202926.0 035 $a(CKB)3800000000216388 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54099 035 $a(oapen)doab54099 035 $a(EXLCZ)993800000000216388 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMuscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms 210 $cFrontiers Media SA$d2017 215 $a1 online resource (104 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-103-8 330 $aAging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions. 517 $aMuscle-Tendon-Innervation Unit 606 $aNeurosciences$2bicssc 610 $aAging 610 $aAnimal Models 610 $acongenital muscular dystrophy 610 $ainnervation 610 $aMuscle 610 $aNanoparticles 610 $aParkinson's camptocormia 610 $aStem/progenitor cells 610 $aTendon 610 $atherapy 615 7$aNeurosciences 700 $aBonaldo$b Paolo$4auth$01858491 702 $aFaldini$b C$g(Cesare)$4auth 702 $aMerlini$b L$g(Luciano)$4auth 906 $aBOOK 912 $a9910220038903321 996 $aMuscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms$94460865 997 $aUNINA