LEADER 00932nam0-22003251i-450 001 990001648440403321 005 20210301131537.0 035 $a000164844 035 $aFED01000164844 035 $a(Aleph)000164844FED01 035 $a000164844 100 $a20030910d1984----km-y0itay50------ba 101 1 $aita$cger 102 $aIT 105 $aa 001yy 200 1 $a<>sistema ormonale delle piante$fKarl Dorffling 210 $aBologna$cEd. CLUEB$d1984 215 $aXI, 252 p.$cill.$d24 cm 610 0 $aFitormoni 676 $a571.742$v23$zita 700 1$aDorffling,$bKarl$070974 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990001648440403321 952 $a60 571.42 DORK 1984 TER$b3965$fFAGBC 952 $a60 571.742 DORK 1984$b3936$fFAGBC 952 $a60 571.742 DORK 1984 BIS$b3964$fFAGBC 959 $aFAGBC 996 $aSistema ormonale delle piante$975599 997 $aUNINA LEADER 04866nam 2200613Ia 450 001 9910739439803321 005 20200520144314.0 010 $a1-4614-7645-3 024 7 $a10.1007/978-1-4614-7645-0 035 $a(CKB)2670000000530491 035 $a(EBL)1398454 035 $a(OCoLC)858763604 035 $a(SSID)ssj0000986611 035 $a(PQKBManifestationID)11528697 035 $a(PQKBTitleCode)TC0000986611 035 $a(PQKBWorkID)10957348 035 $a(PQKB)10736094 035 $a(DE-He213)978-1-4614-7645-0 035 $a(MiAaPQ)EBC1398454 035 $a(PPN)172419611 035 $a(EXLCZ)992670000000530491 100 $a20111102d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNext generation sequencing in cancer research$hVolume 1$iDecoding the cancer genome /$fWei Wu, Hani Choudhry, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer Science$d2013 215 $a1 online resource (383 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-7644-5 311 $a1-4899-8808-4 320 $aIncludes bibliographical references and index. 327 $aIntroduction: next generation sequencing technology and cancer research -- The majority of total nuclear-encoded non-ribosomal RNA in a human cell is ?dark matter? unannotated RNA -- Total RNA-seq of breast cancer in hypoxia -- Altered antisense-to-sense transcript ratios in breast cancer -- Identification of piRNAs in Hela cells by massive parallel sequencing -- Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia -- Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome -- Whole-exome sequencing in CIC and IDH1/2 contributing to human oligodendroglioma -- Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing -- Tumour evolution inferred by single-cell sequencing -- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq -- Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis -- Whole genome DNA methylation analysis based on high throughput sequencing technology -- Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors -- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq -- MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action -- Genome-wide identification of polycomb-associated RNAs by RIP-seq -- Single-molecule sequencing: sequence methods to enable accurate quantisation -- Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells -- Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA -- The genome information process for cancer research: the challenge and perspective -- Index. 330 $aNext Generation Sequencing (NGS) technology has placed important milestones in the life science and changed the direction in biomedical science inclucing cancer. Scientists around the world are attempting to find the root cause of cancer and they are looking for more direct and effective means to cure cancer. This journey to conquer cancer is more optimistic now with the unfolding of the cancer genome. This book focuses on the application of various NGS in the frontier cancer genome research. The 18 chapters in this volume have been written by scientists with many outstanding contributions in their area and the join effort has created comprehensive insightful view on (1) Overview of next generation sequencing technology in cancer genome research (2) Genome regulation and targeted sequencing in cancer (3) RNA transcriptome (coding and non-coding) in cancer genome (4)The challenges of computational biology for cancer genome study. This book is a state-of-the-art reference to all scientific researchers and onologists who are interested in the understanding of the cancer initiatome at whole genome scale and to those are keen to translate the ?base pairs to bedside? for better management of cancer patients in the era of personalized medicine. 606 $aCancer$xGenetic aspects 606 $aGene mapping 615 0$aCancer$xGenetic aspects. 615 0$aGene mapping. 676 $a570285 676 $a599935 676 $a610 676 $a611.01816 701 $aWu$b Wei$0344741 701 $aChoudhry$b Hani$01762249 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910739439803321 996 $aNext generation sequencing in cancer research$94202041 997 $aUNINA