LEADER 01023nam0-22003491i-450- 001 990000903440403321 005 20040126181831.0 010 $a88-7075-566-5 035 $a000090344 035 $aFED01000090344 035 $a(Aleph)000090344FED01 035 $a000090344 100 $a20030113d2002----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $aa-------001yy 200 1 $aComunicare la biblioteca$enuove strategie di marketing e modelli di interazione$ga cura di Ornella Foglieni 210 $aMilano$cEditrice Bibliografica$d2002 215 $a220 p.$cill.$d24 cm 225 1 $a<>cantiere biblioteca$v10 610 0 $aBiblioteche$aServizi$aMarketing 676 $a025.19 700 1$aFoglieni,$bOrnella$09748 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000903440403321 952 $a13 U 03 22$b12849$fFINBC 952 $a80 XXVI 105$b9814$fFFABC 959 $aFINBC 959 $aFFABC 996 $aComunicare la biblioteca$9357631 997 $aUNINA LEADER 03071nam 2200433z- 450 001 9910220054503321 005 20210211 035 $a(CKB)3800000000216233 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40719 035 $a(oapen)doab40719 035 $a(EXLCZ)993800000000216233 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAlzheimer's Disease and the Fornix 210 $cFrontiers Media SA$d2016 215 $a1 online resource (110 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-959-2 330 $aThis e-book focuses primarily on the role of the fornix as a functional, prognostic, and diagnostic marker of Alzheimer's disease (AD), and the application of such a marker in clinical practice. Researchers have long been focused on the cortical pathology of AD, since the most important pathologic features are the senile plaques found in the cortex, and the neurofibrillary tangles and neuronal loss that start from the entorhinal cortex and the hippocampus. In addition to gray matter structures, histopathological studies indicate that the white matter is also altered in AD. The fornix is a white matter bundle that constitutes a core element of the limbic circuits, and is one of the most important anatomical structures related to memory. The fornices originate from the bilateral hippocampi, merge at the midline of the brain, again divide into the left and right side, and then into the precommissural and the postcommissural fibers, and terminate at the septal nuclei, nucleus accumbens (precommissural fornix), and hypothalamus (postcommissural fornix). These functional and anatomical features of the fornix have naturally captured researchers' attention as possible diagnostic and prognostic markers of AD. Growing evidence indicates that the alterations seen in the fornix are potentially a good marker with which to predict future conversion from mild cognitive impairment to AD, and even from a cognitively normal state to AD. The degree of alteration is correlated with the degree of memory impairment, indicating the potential for the use of the fornix as a functional marker. Moreover, there have been attempts to stimulate the fornix to recover the cognitive function lost with AD. Our goal is to provide information about the status of current research and to facilitate further scientific and clinical advancement in this topic. 606 $aNeurosciences$2bicssc 610 $aAlzheimer's disease 610 $aCognition 610 $aDiffusion Tensor Imaging 610 $aFornix 610 $aLimbic 610 $aMemory 610 $aMild Cognitive Impairment 610 $anormal aging 615 7$aNeurosciences 700 $aConstantine G. Lyketsos$4auth$01196274 702 $aKenichi Oishi$4auth 906 $aBOOK 912 $a9910220054503321 996 $aAlzheimer's Disease and the Fornix$93040934 997 $aUNINA