LEADER 00808nam0-22002771i-450- 001 990000734010403321 005 20001010 035 $a000073401 035 $aFED01000073401 035 $a(Aleph)000073401FED01 035 $a000073401 100 $a20001010d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aTecnica della costruzioni civili, rurali idrauliche, stradali$eprogetti e verifiche 210 $aMilano$cHoepli$d1981 215 $aXIX, 695 p. ill. 25 cm 700 1$aLucchesi,$bDomenico$01244 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000734010403321 952 $aTECN B 580$b12419$fFARBC 959 $aFARBC 996 $aTecnica della costruzioni civili, rurali idrauliche, stradali$9322792 997 $aUNINA DB $aING01 LEADER 05222nam 2200625 450 001 9910144010103321 005 20230422044845.0 010 $a1-281-84248-6 010 $a9786611842482 010 $a3-527-61370-6 010 $a3-527-61371-4 035 $a(CKB)1000000000376031 035 $a(EBL)481320 035 $a(SSID)ssj0000183820 035 $a(PQKBManifestationID)11170428 035 $a(PQKBTitleCode)TC0000183820 035 $a(PQKBWorkID)10199687 035 $a(PQKB)10097173 035 $a(MiAaPQ)EBC481320 035 $a(OCoLC)212131900 035 $a(EXLCZ)991000000000376031 100 $a20160818h19991999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIron metabolism $einorganic biochemistry and regulatory mechanisms /$fedited by Gloria C. Ferreira, Jose? J. G. Moura, Ricardo Franco 210 1$aWeinheim, Germany :$cWiley-VCH,$d1999. 210 4$dİ1999 215 $a1 online resource (412 p.) 300 $aIncludes index. 311 $a3-527-29653-0 327 $aIron Metabolism; Contents; Iron Metabolism Regulation and Iron Storage; Iron and Regulation of Heme Biosynthesis; 1 Iron-dependent regulation of bacterial heme biosynthesis; 1.1 Introduction; 1.2 Summary of heme biosynthetic pathways; 1.3 Mediators of iron-dependent regulation of iron metabolism; 1.4 Regulation of heme synthesis by iron; 2 5-Aminolevulinate synthase and mammalian heme biosynthesis; 2.1 Introduction: 5-aminolevulinate synthase and iron; 2.2 Structure and mechanism: early studies; 2.2.1 Isolation, purification and identification of the PLP cofactor 327 $a2.2.2 Steady-state kinetics and mechanism of ALAS2.3 Structure and function: the active site of ALAS; 2.3.1 Identification of the Schiff base linkage between PLP and lysine-313; 2.3.2 Role of a glycine-rich loop as a PLP cofactor-binding site; 2.3.3 Role of aspartate-279 in enhancing the function of PLP and in ALAS catalysis; 2.3.4 Role of tyrosine-121 in the PLP cofactor binding; 2.3.5 Role of arginine-439 in substrate binding; 2.3.6 Active site intersubunit arrangement; 2.4 Conclusions; 3 Ferrochelatase: a new iron sulfur center-containing enzyme; 3.1 Introduction 327 $a3.2 Identification, purification and characterization of ferrochelatase3.3 Steady-state kinetic properties of ferrochelatase; 3.3.1 Ferrochelatase reaction mechanism; 3.3.2 Reducing conditions are not essential for ferrochelatase activity; 3.3.3 Site-directed mutagenesis; 3.3.4 Iron-substrate ligands as determined by Mossbauer spectroscopy; 3.4 The [2Fe-2S] cluster of mammalian ferrochelatases; 3.4.1 Conserved cysteines and iron-sulfur cluster binding; 3.4.2 Spectroscopic characterization of the [2Fe-2S] cluster; 3.5 The three-dimensional structure of Bacillus subtilis ferrochelatase 327 $a3.6 ConclusionsRegulation of Iron Transport and Metabolism; 4 The biochemistry and molecular biology of iron metabolism in yeast; 4.1 Introduction; 4.2 Iron transport in Saccharomyces cerevisiae; 4.2.2 Identification of FET3; 4.2.3 Fet3p is a multicopper oxidase; 4.2.4 Fet3p acts as a ferroxidase to mediate iron transport; 4.3 Oxidase-permease based iron transport systems in other species; 5 Role of redox-active metals in the regulation of the metallothionein and heme oxygenase genes by heme and hemopexin; 5.1 Introduction; 5.2 Hemopexin; 5.2.1 Structure; 5.3 Tissue expression of hemopexin 327 $a5.3.1 Liver5.3.2 Barrier tissues; 5.4 Heme- and heme-hemopexin-mediated effects; 5.4.1 Target tissues; 5.4.2 Responses; 5.4.2.1 Interactions between the hemopexin and transferrin systems; 5.5 Biochemical and cellular consequences of heme-hemopexin: comparison with free heme; 5.5.1 Protective role of hemopexin; 5.5.2 Increased oxidation state; 5.5.3 Transcription factors; 5.5.3.1 Redox sensitive; 5.5.3.2 For metallothionein regulation; 5.5.4 Links between iron and copper in iron homeostasis; 5.5.6 Links between heme and copper and cellular homeostasis 327 $a5.5.6.1 Role of copper in certain of the cellular and regulatory effects of hemopexin: intracellular oxidation state 330 $aIron plays a crucial role in many biochemical processes. In recent years intensive research has led to a better understanding of the function of iron in cellular metabolism. In more than twenty articles internationally renowned experts give a thorough account of the recent developments of this fascinating field. The book focuses on the central questions, e.g. transport, storage, and utilization of iron in cells, the three-dimensional structure of iron-containing proteins, the physiological function of heme and iron sulfur-containing proteins, and the regulatory mechanisms in heme biosynthesis 606 $aIron$xMetabolism 615 0$aIron$xMetabolism. 676 $a572.517 676 $a572.5174 676 $a572/.5174 702 $aFerreira$b Glo?ria C. 702 $aMoura$b Jose? J. G. 702 $aFranco$b Ricardo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144010103321 996 $aIron Metabolism$9834677 997 $aUNINA LEADER 05426nam 2200913 450 001 9910788099603321 005 20230729072917.0 010 $a1-63853-066-1 010 $a1-62623-087-0 024 7 $a10.1055/b-002-101156 035 $a(CKB)2670000000573771 035 $a(EBL)1831165 035 $a(SSID)ssj0001369032 035 $a(PQKBManifestationID)12571194 035 $a(PQKBTitleCode)TC0001369032 035 $a(PQKBWorkID)11289127 035 $a(PQKB)10504227 035 $a(Au-PeEL)EBL1831165 035 $a(CaPaEBR)ebr10980866 035 $a(CaONFJC)MIL655564 035 $a(OCoLC)894791591 035 $a10.1055-b-002-101156 035 $a(DE-2912)1496428268103 035 $a(MiAaPQ)EBC1831165 035 $a(EXLCZ)992670000000573771 100 $a20141121h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aVascular Lesions of the Head and Neck $eDiagnosis and Management /$fby: Persky, Mark S., Waner, Milton, Blei, Francine, Berenstein, Alejandro 210 1$aNew York, New York :$cThieme,$d2015. 210 4$dİ2015 215 $a1 online resource (172 p.) 300 $aDescription based upon print version of record. 311 $a1-60406-059-X 311 $a1-322-24284-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aVascular Lesions of the Head and Neck: Diagnosis and Management; Title Page; Copyright; Dedication; Contents; Foreword; Preface; Acknowledgments; Contributors; 1 Classification of Vascular Anomalies; 2 Congenital Vascular Tumors; 3 Pathology of Congenital Vascular Lesions; 4 The Natural History, Physical Findings, and Evaluation of Hemangiomas; 5 Hemangioma Syndromes; 6 Radiologic Evaluation of Hemangiomas; 7 Medical Management of Hemangiomas; 8 Treatment of Infantile Hemangiomas; 9 Radiologic Evaluation of Vascular Malformations 327 $a10 The Role of Endovascular Surgery in the Management of Vascular Lesions of the Head and Neck11 Treatment of Port-Wine Stains; 12 The Surgical Management of Vascular Malformations; 13 Evaluation and Treatment of Vascular Neoplasms; 14 Pathology of Acquired Vascular Neoplasms of the Head and Neck; Index 330 $aVascular Lesions of the Head and Neck provides readers with an up-to-date review of the pathology, basic science, classification, radiologic features, and treatment modalities for vascular lesions of the head and neck. It covers all recent developments in medical and surgical treatment, laser technology, endovascular techniques, and appropriate radiation protocols that dramatically affect the evaluation and management of patients with vascular lesions. This book is an excellent desk reference for all otolaryngologists, plastic surgeons, vascular interventional radiologists, pediatricians, derm 606 $aDiagnosis, Differential 606 $aHemangiomas 615 0$aDiagnosis, Differential. 615 0$aHemangiomas. 676 $a616.8/1 700 $aBae-Harboe$b Yoon-Soo Cindy$4aut$4http://id.loc.gov/vocabulary/relators/aut$01531488 702 $aPersky$b Mark S$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWaner$b Milton$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBlei$b Francine$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBerenstein$b Alejandro$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBerenstein$b Alejandro$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBlei$b Francine$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBrightman$b Lori A$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aDishop$b Megan K$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aFay$b Aaron$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aFrieden$b Ilona J$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aGeronemus$b Roy G$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aHaggstrom$b Anita N$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aJessup$b Chad J$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aLaury$b Anna R$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aLefton$b Daniel R$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aMihm Jr$b Martin C$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aNiimi$b Yasunari$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aO$b Teresa Min-Jung$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aPersky$b Mark S$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aPhung$b Thuy L$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aRozell-Shannon$b Linda$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aShatzkes$b Deborah R$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aTran$b Theresa N$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aWaner$b Milton$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aWassef$b Michel$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aWenig$b Bruce M$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bDE-2912 906 $aBOOK 912 $a9910788099603321 996 $aVascular Lesions of the Head and Neck$93777180 997 $aUNINA