LEADER 01021nam0-22003371i-450 001 990000724630403321 005 20230308112214.0 035 $a000072463 035 $aFED01000072463 035 $a(Aleph)000072463FED01 100 $a20020821d1964----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $aa-------001yy 200 1 $aCastel Nuovo$eReggia angioina e aragonese di Napoli$fRiccardo Filangieri$gprefazione di Bruno Molajoli 210 $aNapoli$cL'Arte tipografica$d1964 215 $aXI, 309 p.$cill.$d31 cm 610 0 $aNapoli$aCastel Nuovo 610 0 $aFilangieri Riccardo$aStudi 700 1$aFilangieri,$bRiccardo$f<1882-1959>$022759 702 1$aMolajoli,$bBruno$f<1905-1985> 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000724630403321 952 $aRARI C 66$b12371$fFARBC 952 $aFONDO ROSSI 4474$bROSSI 4595$fFARBC 952 $a01.167$b4496$fDARST 959 $aFARBC 959 $aDARST 996 $aCastel Nuovo$9323430 997 $aUNINA LEADER 03353oam 22007212a 450 001 9910815907903321 005 20240516134423.0 010 $a9781118354322 010 $a111835432X 010 $a9781299314597 010 $a1299314597 010 $a9781118354339 010 $a1118354338 010 $a9781118354308 010 $a1118354303 010 $a9781118354315 010 $a1118354311 035 $a(CKB)2670000000231132 035 $a(EBL)875932 035 $a(OCoLC)805560505 035 $a(SSID)ssj0000694988 035 $a(PQKBManifestationID)11416226 035 $a(PQKBTitleCode)TC0000694988 035 $a(PQKBWorkID)10686134 035 $a(PQKB)10639388 035 $a(DLC) 2012008118 035 $a(MiAaPQ)EBC875932 035 $a(PPN)178867330 035 $a(Perlego)1000766 035 $a(EXLCZ)992670000000231132 100 $a20120224d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiopharmaceutics modeling and simulations $etheory, practice, methods, and applications /$fKiyohiko Sugano 205 $a1st ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2013 215 $a1 online resource (521 p.) 300 $aDescription based upon print version of record. 311 08$a9781118028681 311 08$a1118028686 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice. 330 $a A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professio 606 $aBiopharmaceutics$xmethods 606 $aComputer Simulation 606 $aDrug Compounding$xmethods 606 $aModels, Theoretical 615 12$aBiopharmaceutics$xmethods. 615 22$aComputer Simulation. 615 22$aDrug Compounding$xmethods. 615 22$aModels, Theoretical. 676 $a615.19 700 $aSugano$b Kiyohiko$01642541 801 0$bDLC 801 1$bDLC 801 2$bDLC 906 $aBOOK 912 $a9910815907903321 996 $aBiopharmaceutics modeling and simulations$93987299 997 $aUNINA LEADER 04027nam 22006015 450 001 9910520062503321 005 20250504232142.0 010 $a3-662-64008-2 024 7 $a10.1007/978-3-662-64008-1 035 $a(MiAaPQ)EBC6840238 035 $a(Au-PeEL)EBL6840238 035 $a(CKB)20443410600041 035 $a(PPN)269153845 035 $a(DE-He213)978-3-662-64008-1 035 $a(EXLCZ)9920443410600041 100 $a20220103d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aConfigural Frequency Analysis $eFoundations, Models, and Applications /$fby Alexander von Eye, Wolfgang Wiedermann 205 $a1st ed. 2021. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2021. 215 $a1 online resource (401 pages) 225 1 $aStatistics for Social and Behavioral Sciences,$x2199-7365 311 08$aPrint version: von Eye, Alexander Configural Frequency Analysis Berlin, Heidelberg : Springer Berlin / Heidelberg,c2022 9783662640074 320 $aIncludes bibliographical references and index. 327 $aPreface -- 1 Questions that Can Be Answered with CFA -- 2 Elements of CFA -- 3 Models of CFA -- 4 Models of Longitudinal CFA -- 5 Designs for CFA -- 6 Special Variables in CFA -- 7 The CFA Treasure Chest -- 8 CFA Software -- Index. 330 $aThis unique book provides a comprehensive and detailed coverage of configural frequency analysis (CFA), the most useful method of analysis of categorical data in person-oriented research. It presents the foundations, methods, and models of CFA and features numerous empirical data examples from a range of disciplines that can be reproduced by the readers. It also addresses computer applications, including relevant R packages and modules. Configural frequency analysis is a statistical method that allows the processing of important and interesting questions in categorical data. The perspective of CFA differs from the usual perspective of relations among variables; its focus is on patterns of variable categories that stand out with respect to specific hypotheses, and as such, CFA allows for testing numerous substantive hypotheses. The book describes the origins of CFA and their relation to chi-square analysis as well as the developments that are based on log-linear modeling. The models covered range from simple models of variable independence to complex models that are needed when causal hypotheses are tested. Empirical data examples are provided for each model. New models are introduced for person-oriented mediation analysis and locally optimized time series analysis, and new results concerning the characteristics of CFA methods are bolstered using Monte Carlo simulations. Primarily intended for researchers and students in the social and behavioral sciences, the book will also appeal to anyone who deals with categorical data from a person-centered perspective. 410 0$aStatistics for Social and Behavioral Sciences,$x2199-7365 606 $aSocial sciences$xStatistical methods 606 $aPsychology$xMethodology 606 $aStatistics 606 $aStatistics in Social Sciences, Humanities, Law, Education, Behavorial Sciences, Public Policy 606 $aPsychological Methods 606 $aStatistical Theory and Methods 615 0$aSocial sciences$xStatistical methods. 615 0$aPsychology$xMethodology. 615 0$aStatistics. 615 14$aStatistics in Social Sciences, Humanities, Law, Education, Behavorial Sciences, Public Policy. 615 24$aPsychological Methods. 615 24$aStatistical Theory and Methods. 676 $a519.535 700 $aEye$b Alexander von$0148929 702 $aWiedermann$b Wolfgang$f1981- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910520062503321 996 $aConfigural frequency analysis$92624414 997 $aUNINA