LEADER 00920cam0-22003011i-450- 001 990000215210403321 005 20061026121226.0 035 $a000021521 035 $aFED01000021521 035 $a(Aleph)000021521FED01 035 $a000021521 100 $a20020821d1870----km-y0itay50------ba 101 0 $afre 102 $aFR 105 $af-------001yy 200 1 $aCours pratique de construction$erédigé conformément au paragraphe cinq du programme officiel des connaissancespratiques exigées pour devenir ingénieur$fLouis Preud'Homme 210 $aParis-Liège$cJ. Baudry$d1870 215 $a2 v.$d23 cm 610 0 $aScienza delle costruzioni 676 $a624.17 700 1$aPreud'homme,$bLouis 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000215210403321 952 $a13 AR 21 C 07$b3872$fFINBC 952 $a13 AR 21 C 06$b3871$fFINBC 959 $aFINBC 997 $aUNINA LEADER 00848nam0-22003011i-450- 001 990006211730403321 005 19980601 035 $a000621173 035 $aFED01000621173 035 $a(Aleph)000621173FED01 035 $a000621173 100 $a19980601d1973----km-y0itay50------ba 105 $a--------00-yy 200 1 $a<>animazione delle vendite$fBernard Krief ; traduzione dal francese di Anna Morlacchi. 210 $aMilano$cEtas Kompass Libri$d1973 215 $aX,, 76 p.$d21 cm 225 1 $aManagement$v24 676 $a658 700 1$aKrief,$bBernard$0235195 702 1$aMorlacchi,$bAnna 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006211730403321 952 $aVII M 26 (24)$b20787*$fFGBC 959 $aFGBC 996 $aAnimazione delle vendite$9647795 997 $aUNINA DB $aGIU01 LEADER 03979nam 2200565 450 001 9910137196803321 005 20230621140027.0 010 $a9782889192830$b(ebook) 035 $a(CKB)3710000000526121 035 $a(SSID)ssj0001680353 035 $a(PQKBManifestationID)16496204 035 $a(PQKBTitleCode)TC0001680353 035 $a(PQKBWorkID)15028468 035 $a(PQKB)10642565 035 $a(WaSeSS)IndRDA00056357 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53605 035 $a(EXLCZ)993710000000526121 100 $a20160829d2014 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMitochondria $ethe cell powerhouse and nexus of stress /$ftopic editors: Sabzali Javadov and Andrey V. Kuznetsov 210 $cFrontiers Media SA$d2014 210 31$aFrance :$cFrontiers Media SA,$d2014 215 $a1 online resource (121 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aMitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and pathological conditions through their participation in many intracellular signalling pathways. Studies over the last 30 years provide strong evidence that mitochondria are the nexus of various stresses which initiate cell death through apoptosis, oncosis, necrosis and autophagy depending on the severity of the stress and cellular energy status. The release of several pro-apoptotic proteins such as cytochrome c, Smac/DIABLO, AIF, endonuclease G from intermembrane space initiates both caspase-dependent and caspase-independent apoptosis. The formation of the mitochondrial permeability transition pore in the IMM promotes cell death mostly through necrosis whereas a mild stress activates autophagy. Due to their critical roles in both cell death and survival mitochondria have been widely considered as an important target for various pharmacological and conditional therapeutic approaches. Currently, a large number of mitochondria-targeted agents are suggested to prevent (in ischemia reperfusion injury, cardiovascular, neurodegenerative and other diseases) or stimulate (in various cancers) cell death. This Research Topic will focus on the role of mitochondria in the regulation of cell metabolism and signalling under physiological and pathological conditions. Studies performed on cultured cells and isolated organs/tissues using different animal and cellular models of various diseases will be also included and discussed. 606 $aCytology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $amitochondrial physiology 610 $aOxidative Stress 610 $aCell Death 610 $aMitochondrial ion channels 610 $amitochondrial metabolism 615 7$aCytology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aAndrey V. Kuznetsov$4auth$01366920 702 $aKuznetsov$b Andrey V 702 $aJavadov$b Sabzali 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137196803321 996 $aMitochondria$93389444 997 $aUNINA