LEADER 00851nam0-22003011i-450- 001 990000076630403321 035 $a000007663 035 $aFED01000007663 035 $a(Aleph)000007663FED01 035 $a000007663 100 $a20011111d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $a<>machines à glace et les applications industrielles du froid$fR. Leze. 210 $aParis$cB. Tignol$d<1889> 215 $a210 p., 1 tav.$cill.$d18 cm 225 1 $aBibliothèque des actualités industrielles$v27 610 0 $aImpianti frigoriferi 610 0 $aMacchine frigorifere 676 $a621.5 700 1$aLeze,$bR. 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000076630403321 952 $a13 AR 23 A 08$b1121$fFINBC 959 $aFINBC 997 $aUNINA DB $aING01 LEADER 03163nam 2200433z- 450 001 9910161647803321 005 20210211 035 $a(CKB)3710000001041986 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54516 035 $a(oapen)doab54516 035 $a(EXLCZ)993710000001041986 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeuronal Mechanics and Transport 210 $cFrontiers Media SA$d2016 215 $a1 online resource (212 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-823-5 330 $aUnderstanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries. 606 $aNeurosciences$2bicssc 610 $aAxonal elongation 610 $aforce 610 $aglia 610 $aneuronal development 610 $aneuronal mechanics 610 $aNeuronal morphology 610 $aNeuronal transport 610 $astiffness 615 7$aNeurosciences 700 $aKyle E. Miller$4auth$01331949 702 $aDaniel M. Suter$4auth 906 $aBOOK 912 $a9910161647803321 996 $aNeuronal Mechanics and Transport$93040693 997 $aUNINA