LEADER 01286nam2-2200409---450- 001 990001238320203316 005 20060207142330.0 035 $a000123832 035 $aUSA01000123832 035 $a(ALEPH)000123832USA01 035 $a000123832 100 $a20031104d1964----km-y0itay0103----ba 101 0 $aita 102 $aIT 105 $a||||||||001yy 200 1 $a<>: Orlando Furioso$fLudovico Ariosto$ga cura di Cesare Segre 210 $aMilano$cMondadori$d1964 215 $aLIV, 1422 p.$d18 cm 225 2 $a<> Classici Mondadori 410 0$12001$a<> Classici Mondadori 454 1$12001 461 1$1001000123821$12001$aTutte le opere 676 $a858.3 700 1$aARIOSTO,$bLudovico$f<1474-1533>$0192228 702 1$aSEGRE,$bCesare 801 0$aIT$bsalbc$gISBD 912 $a990001238320203316 951 $aVI.3. Coll.27/ 15/1 (V A coll. 17/15 I)$b64423 L.M.$cV A coll. 951 $aVI.3. 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This class of herbicides acted as a competitive inhibitor of the pyruvate dehydrogenase complex (PDHc) to control weeds. The bioreasoning and systematic approach, from basic research to field tests of candidate compounds, are introduced. The basic research covers the molecular design, chemical synthesis, biological activities evaluation, structure-activity relationship analysis and structural optimization. Subsequently, the book reviews the biochemistry of PDHc inhibitors, the selectivity between mammals and plants, and the mechanism of herbicidal activity of novel alkylphosphonates as selective PDHc inhibitors. Field trials for selected alkylphosphonate candidates as herbicides are also included. This book provides a sound basis for the rational design and development of novel herbicides as effective PDHc inhibitors with good enzyme-selective inhibition of plant PDHc between mammals and plants. These studies take full advantages of the low toxicity and low residual impact of selective PHDc inhibitors to design an effective and environmentally friendly herbicide. This book is based on twenty years of research on alkylphosphonates and phosphorus-containing PDHc inhibitors, and demonstrates how to develop these PDHc inhibitors as an effective and ?green? herbicide candidate.   Hong-Wu He, PhD, is a Professor at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, and Director of the Institute of Pesticide Chemistry, College of Chemistry, Central China Normal University, China. Hao Peng, PhD, and Xiao-Song Tan are both Associate Professors at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, College of Chemistry, Central China Normal University, China. 606 $aChemistry, Organic 606 $aBotanical chemistry 606 $aEnvironmental chemistry 606 $aAgriculture 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 606 $aPlant Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14021 606 $aEnvironmental Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/U15000 606 $aAgriculture$3https://scigraph.springernature.com/ontologies/product-market-codes/L11006 615 0$aChemistry, Organic. 615 0$aBotanical chemistry. 615 0$aEnvironmental chemistry. 615 0$aAgriculture. 615 14$aOrganic Chemistry. 615 24$aPlant Biochemistry. 615 24$aEnvironmental Chemistry. 615 24$aAgriculture. 676 $a54 676 $a547 676 $a572572 676 $a577.14 676 $a630 700 $aHe$b Hong-Wu$4aut$4http://id.loc.gov/vocabulary/relators/aut$01061943 702 $aPeng$b Hao$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aTan$b Xiao-Song$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910298636303321 996 $aEnvironmentally Friendly Alkylphosphonate Herbicides$92521553 997 $aUNINA