LEADER 01212nam0 22003253i 450 001 LO11513963 005 20231121125525.0 010 $a3423022965 100 $a20160623d1992 ||||0itac50 ba 101 | $ager 102 $ade 181 1$6z01$ai $bxxxe 182 1$6z01$an 200 1 $aWerke$eDramen, Prosa, Gedichte$fJakob Michael Reinhold Lenz$g [Ausgewählt und kommentiert von Karen Lauer$gmit einem Nachwort von Gerhard Sauder] 210 $aMünchen$cDeutscher Taschenbuch Verlag$d1992 215 $a602 p.$d19 cm 225 | $aDTV klassik$v2296 410 0$1001BVE0001854$12001 $aDTV klassik$v2296 700 1$aLenz$b, Jakob Michael Reinhold$3AQ1V002342$0291268 702 1$aLauer$b, Karen$3IEIV089884 702 1$aSauder$b, Gerhard$3TO0V078006 790 1$aLenz$b, Jakob$3TO0V643818$zLenz, Jakob Michael Reinhold 801 3$aIT$bIT-01$c20160623 850 $aIT-FR0017 899 $aBiblioteca umanistica Giorgio Aprea$bFR0017 $eN 912 $aLO11513963 950 0$aBiblioteca umanistica Giorgio Aprea$d 52MAG 1/3022$e 52FLS0000034485 VMB RS $fA $h20181126$i20181126 977 $a 52 996 $aWerke$9173544 997 $aUNICAS LEADER 04137nam 2201081z- 450 001 9910557152603321 005 20210501 035 $a(CKB)5400000000040531 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/68644 035 $a(oapen)doab68644 035 $a(EXLCZ)995400000000040531 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aFree Radical Research in Cancer 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (192 p.) 311 08$a3-03936-088-4 311 08$a3-03936-089-2 330 $aCancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer. 606 $aTechnology: general issues$2bicssc 610 $a4-hydroxy-2-nonenal 610 $a5-Fluorouracil 610 $aandrogen deprivation therapy 610 $aandrogen receptor (AR), AR-V7 610 $aanti-androgen 610 $aantioxidant 610 $aantioxidant proteins 610 $aantioxidant therapy 610 $aantioxidants 610 $aascorbate 610 $aayurveda 610 $abardoxolone methyl 610 $ableomycin 610 $abreast cancer 610 $abreast cancer stem cells 610 $acalcium channel 610 $acancer 610 $acancer chemotherapy 610 $acancer metabolism 610 $acancer treatment 610 $acarbonylation 610 $acastration-resistant prostate cancer 610 $acell death 610 $achemoprevention and chemotherapy 610 $achemoresistance 610 $achemotherapy-induced toxicity 610 $acisplatin 610 $acombination therapy 610 $adeferasirox 610 $adoxorubicin 610 $aenzalutamide 610 $aextracellular matrix 610 $afree radicals 610 $agranulosa cell tumor 610 $alapachone 610 $alight 610 $alung cancer 610 $amenadione 610 $amethotrexate 610 $amitochondria 610 $amyelodysplastic syndromes 610 $an/a 610 $anew therapeutic strategies 610 $anitric oxide 610 $aNQO1 610 $aNQO1*2 610 $aNRF2 610 $aovary 610 $aoxaliplatin 610 $aoxidative stress 610 $aozone therapy 610 $aphotodynamic therapy 610 $apolymorphism 610 $aprostate cancer 610 $aquinone 610 $areactive oxygen species 610 $areactive oxygen species (ROS) 610 $asinglet oxygen 610 $asperm 610 $atherapy resistance 610 $atriphala 610 $aTrolox 615 7$aTechnology: general issues 700 $aC?ipak Gas?parovic?$b Ana$4edt$01310428 702 $aC?ipak Gas?parovic?$b Ana$4oth 906 $aBOOK 912 $a9910557152603321 996 $aFree Radical Research in Cancer$93029801 997 $aUNINA