LEADER 03092nam0 22004813i 450 001 VAN00264395 005 20260630102934.657 017 70$2N$a9783642456510 035 40$a799183876 100 $a20231004d1988 |0itac50 ba 101 $aeng 102 $aDE 105 $a|||| ||||| 181 $ai$b e 182 $ab 183 $acr 200 1 $aCell Kinetic Modelling and the Chemotherapy of Cancer$fHelmut Knolle 210 $aBerlin$cSpringer$d1988 215 $aviii, 157 p.$d24 cm 327 $aDuring the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re­ levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977). 410 1$1001VAN00256120$12001 $aLecture Notes in Biomathematics$1210 $aBerlin$cSpringer$d1974-1993.$v75 606 $a92-XX$xBiology and other natural sciences [MSC 2020]$3VANC020839$2MF 606 $a92C50$xMedical applications (general) [MSC 2020]$3VANC027825$2MF 606 $a92Cxx$xPhysiological, cellular and medical topics [MSC 2020]$3VANC024650$2MF 610 $aAlgebra$9KW:K 610 $aCancer$9KW:K 610 $aCancer Research$9KW:K 610 $aCell Cycle$9KW:K 610 $aCells$9KW:K 610 $aKinetics$9KW:K 610 $aTumor$9KW:K 610 $atumor growth$9KW:K 620 $dBerlin$3VANL000066 700 1$aKnolle$bHelmut$3VANV218193$057967 712 $aSpringer $3VANV108073$4650 801 $aIT$bSOL$c20260911$gRICA 856 4 $uhttps://doi.org/10.1007/978-3-642-45651-0$zE-book ? Accesso al full-text attraverso riconoscimento IP di Ateneo, proxy e/o Shibboleth 899 $aBIBLIOTECA DEL DIPARTIMENTO DI MATEMATICA E FISICA$1IT-CE0120$2VAN08 912 $fN 912 $aVAN00264395 950 $aBIBLIOTECA DEL DIPARTIMENTO DI MATEMATICA E FISICA$d08DLOAD e-book 6943 $e08eMF6943 20231023 996 $aCell kinetic modelling and the chemotherapy of cancer$9381103 997 $aUNICAMPANIA