LEADER 01136nam0 22002771i 450 001 SUN0021053 005 20160629024953.359 010 $a04-7155-875-3 100 $a20040730d1994 |0engc50 ba 101 $aeng 102 $aUS 105 $a|||| ||||| 200 1 $aAir monitoring by spectroscopic techniques$fedited by Markus W. Sigrist 210 $aNew York$cWiley$dc1994 215 $axxv, 531 p.$cill., maps$d24 cm. 620 $aUS$dNew York$3SUNL000011 676 $a621.366$cFisica applicata. Laser spettroscopia$v22 702 1$aSigrist$b, Markus W.$3SUNV017314 712 $aWiley$3SUNV000201$4650 790 1$aSigrist, M. W.$zSigrist, Markus W.$3SUNV101830 801 $aIT$bSOL$c20201005$gRICA 856 4 $uhttps://books.google.it/books?id=_vkyfs5_OAoC&printsec=frontcover&hl=it 912 $aSUN0021053 950 $aUFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI SCIENZE E TECNOLOGIE AMBIENTALI BIOLOGICHE E FARMACEUTICHE$d17CONS Fg2 $e17FSA596 20040730 $sBuono 996 $aAir monitoring by spectroscopic techniques$91428293 997 $aUNICAMPANIA LEADER 01075cam0-22003371i-450 001 990004025630403321 005 20201217093219.0 010 $a3511034809 035 $a000402563 100 $a19990604d1981----km-y0itay50------ba 101 0 $ager 102 $aDE 105 $ay-------001yy 200 1 $aFriedrich Daniel Ernst Schleiermacher$eAuswahl in vier Bänden$gmit Geleitwort von August Dorner$gherausgegen und eingeleitet von Otto Braun und Johannes Bauer 205 $a2. ed. 210 $aDarmstadt$cScientia Verlag Aalen$d1981 215 $a4 v.$d23 cm 324 $aRipr. dell'ed.: Leipzig, 1927-1928 700 1$aSchleiermacher,$bFriedrich Daniel Ernst$f<1768-1834>$0152253 702 1$aBaur,$bJohannes 702 1$aBraun,$bOtto 702 1$aDorner,$bAugust 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004025630403321 952 $aXI CL S 6(1) - 6(4)$fDFD 952 $a141.6 SCH (1-4)$bBC.1070$fFLFBC 959 $aFLFBC 959 $aDFD 996 $aFriedrich Daniel Ernst Schleiermacher$91762713 997 $aUNINA LEADER 05409nam 2200649Ia 450 001 9910784636103321 005 20200520144314.0 010 $a1-281-03290-5 010 $a9786611032906 010 $a0-08-052592-X 035 $a(CKB)1000000000384970 035 $a(EBL)317003 035 $a(OCoLC)476109390 035 $a(SSID)ssj0000097046 035 $a(PQKBManifestationID)11130840 035 $a(PQKBTitleCode)TC0000097046 035 $a(PQKBWorkID)10112662 035 $a(PQKB)10802744 035 $a(Au-PeEL)EBL317003 035 $a(CaPaEBR)ebr10206345 035 $a(CaONFJC)MIL103290 035 $a(MiAaPQ)EBC317003 035 $a(EXLCZ)991000000000384970 100 $a19971107d1998 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAcute toxicology testing$b[electronic resource] /$fShayne C. Gad, Christopher P. Chengelis 205 $a2nd ed. 210 $aSan Diego $cAcademic Press$dc1998 215 $a1 online resource (561 p.) 300 $aDescription based upon print version of record. 311 $a0-12-272250-7 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion 327 $aPrimary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests 327 $aReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems 327 $aIn Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References 327 $aChapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References 327 $aChapter 12. Statistical Analysis of Acute Toxicology and Safety Studies 330 $aAcute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.Key Features* Over 100 tables summarizing and interpreting 606 $aAlternative toxicity testing 606 $aAcute toxicity testing 615 0$aAlternative toxicity testing. 615 0$aAcute toxicity testing. 676 $a615/.704/028 700 $aGad$b Shayne C.$f1948-$096171 701 $aChengelis$b Christopher P.$f1949-$01560655 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784636103321 996 $aAcute toxicology testing$93826785 997 $aUNINA