LEADER 01230nam0 2200337 450 001 000027070 005 20110913150812.0 100 $a20091216d1938----km-y0itay50------ba 101 0 $aita 102 $aIT 200 1 $aGiuda Iscariota$fLanza Del Vasto 210 $aBari$c<> Laterza & figli$d1938 215 $a212 p.$d22 cm 225 2 $aStudi religiosi ed esoterici$v68 300 $aIn cop. e in testa al front. firma autografa: Sergio de Pilato, dic. '937, XVI 300 $aL. 16 410 0$12001$aStudi religiosi ed esoterici$v68 600 0$aGiuda : Iscariota 676 $a226.092$v(21. ed.)$9Bibbia. Nuovo testamento. Vangeli e Atti degli apostoli. Persone 700 0$aLanza Del Vasto$048493 801 0$aIT$bUniversità della Basilicata - B.I.A.$gRICA$2unimarc 912 $a000027070 996 $aGiuda Iscariota$990684 997 $aUNIBAS BAS $aLETTERE CAT $aTTM$b30$c20091216$lBAS01$h1141 CAT $aTTM$b30$c20100223$lBAS01$h1632 CAT $aTTM$b30$c20100224$lBAS01$h0855 CAT $aATR$b20$c20110913$lBAS01$h1508 FMT Z30 -1$lBAS01$LBAS01$mBOOK$1BASA1$APolo Storico-Umanistico$2FDEP2$BFondo De Pilato Biscione$3FD/109287$6109287$5L109287$820091216$f52$FRari LEADER 04751nam 22006855 450 001 9910150457103321 005 20251116173316.0 010 $a3-319-41523-9 024 7 $a10.1007/978-3-319-41523-9 035 $a(CKB)3710000000943124 035 $a(DE-He213)978-3-319-41523-9 035 $a(MiAaPQ)EBC4740960 035 $a(PPN)197133606 035 $a(EXLCZ)993710000000943124 100 $a20161110d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdhesion G Protein-coupled Receptors $eMolecular, Physiological and Pharmacological Principles in Health and Disease /$fedited by Tobias Langenhan, Torsten Schöneberg 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XIV, 403 p. 68 illus., 67 illus. in color.) 225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v234 311 08$a3-319-41521-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs -- 7TM Domain Structure of Adhesion GPCRs -- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs -- Versatile Signaling Activity of Adhesion GPCRs -- Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans -- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development -- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors -- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration -- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs -- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis. 330 $aLatest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function. 410 0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v234 606 $aPharmacology 606 $aHuman physiology 606 $aHuman genetics 606 $aCytology 606 $aClinical biochemistry 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aMedical Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/H35005 615 0$aPharmacology. 615 0$aHuman physiology. 615 0$aHuman genetics. 615 0$aCytology. 615 0$aClinical biochemistry. 615 14$aPharmacology/Toxicology. 615 24$aHuman Physiology. 615 24$aHuman Genetics. 615 24$aCell Biology. 615 24$aMedical Biochemistry. 676 $a613 702 $aLangenhan$b Tobias$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aScho?neberg$b Torsten$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910150457103321 996 $aAdhesion G Protein-coupled Receptors$92527543 997 $aUNINA