00988cam2 22002653 450 SOBE0007204920220616082138.020220601d1978 |||||ita|0103 baitaIT<<42: >>LeopardiAchille TartaroBariLaterza1978203 p.22 cm001SOBE000460992001 Letteratura italiana Laterza / direttore Carlo MuscettaLeopardiSOBA00024329139910Tartaro, AchilleAF00014666070164850ITUNISOB20220616RICAUNISOBUNISOBSaggi|H176564SOBE00072049M 102 Monografia moderna SBNMFondo|LeopardianoSaggi|H000029CON17656420220527FondoLeopardianoDonorovitoUNISOBUNISOB20220601134242.020220616082138.0rovitoPer le modalità di consultazione vedi homepage della Biblioteca link FondiLeopardi139910UNISOB02984nam 2200385z- 450 991034675490332120210211(CKB)4920000000094165(oapen)https://directory.doabooks.org/handle/20.500.12854/42237(oapen)doab42237(EXLCZ)99492000000009416520202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierBiology and Pathogenesis of LegionellaFrontiers Media SA20181 online resource (181 p.)Frontiers Research Topics2-88945-661-7 Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires' disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative "omics", it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.Dot/Icm effectorHost-Pathogen Interactionsintravacuolar pathogenLegionellaLegionnaires' DiseaseMatthias Machnerauth1331091Hayley NewtonauthElizabeth HartlandauthBOOK9910346754903321Biology and Pathogenesis of Legionella3040119UNINA