00948cam0 2200265 450 E60020002347720190108152957.020061211d1984 |||||ita|0103 baitaITGentile e il primato della tradizione culturale italianail dibattito politico all'interno del fascismoDanilo VenerusoRomaEdizioni studium1984271 p21 cm<La >cultura28001LAEC000164042001 La *cultura28Veneruso, DaniloA600200039693070129642ITUNISOB20190108RICAUNISOBUNISOB90040175E600200023477M 102 Monografia moderna SBNM900001035SI40175catenacciUNISOBUNISOB20121015130238.020121015130301.0catenacciGentile e il primato della tradizione culturale italiana623541UNISOB05488nam 22008415 450 991029845850332120200702141154.03-319-22117-510.1007/978-3-319-22117-5(CKB)4340000000000008(SSID)ssj0001583818(PQKBManifestationID)16263610(PQKBTitleCode)TC0001583818(PQKBWorkID)14864774(PQKB)11363346(DE-He213)978-3-319-22117-5(MiAaPQ)EBC6315735(MiAaPQ)EBC5588332(Au-PeEL)EBL5588332(OCoLC)932002609(PPN)190532017(EXLCZ)99434000000000000820151106d2015 u| 0engurnn|008mamaatxtccrFundamentals of Neurodegeneration and Protein Misfolding Disorders /by Martin Beckerman1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (XXII, 378 p. 122 illus., 103 illus. in color.) Biological and Medical Physics, Biomedical Engineering,1618-7210Bibliographic Level Mode of Issuance: Monograph3-319-22116-7 Introduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimer’s Disease -- Parkinson’s Disease -- Huntington’s Disease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.Biological and Medical Physics, Biomedical Engineering,1618-7210NeurosciencesBiophysicsBiophysicsProteinsBiomedical engineeringNeurologyPharmaceutical chemistryNeuroscienceshttps://scigraph.springernature.com/ontologies/product-market-codes/B18006Biological and Medical Physics, Biophysicshttps://scigraph.springernature.com/ontologies/product-market-codes/P27008Protein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Biomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XNeurologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H36001Medicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Neurosciences.Biophysics.Biophysics.Proteins.Biomedical engineering.Neurology.Pharmaceutical chemistry.Neurosciences.Biological and Medical Physics, Biophysics.Protein Science.Biomedical Engineering and Bioengineering.Neurology.Medicinal Chemistry.616.3995Beckerman Martinauthttp://id.loc.gov/vocabulary/relators/aut602888MiAaPQMiAaPQMiAaPQBOOK9910298458503321Fundamentals of Neurodegeneration and Protein Misfolding Disorders2517632UNINA