01264nam0 2200337 450 00002532320090409142603.088-386-6255-620090409d2006----km-y0itay50------baitaITy-------001yyIntroduzione alla statistica per le scienze socialiIan Diamond, Julie Jefferiescon il contributo per l'edizione italiana di Fabio Aiello, Leonardo Librizzi2. ed.Milano [etc.]McGraw-Hill2006X, 294 p.ill.24 cmCollana di istruzione scientificaserie di matematicaTit. orig. : Beginning statistics. An introduction for social scientist2001Collana di istruzione scientificaIntroduzione alla statistica per le scienze sociali44095Scienze socialiMetodi statistici300.7221Diamond,Ian148081Jefferies,Julie148082Aiello,FabioLibrizzi,LeonardoITUNIPARTHENOPE20090409RICAUNIMARC000025323W-010641312NAVA32009Introduzione alla statistica per le scienze sociali44095UNIPARTHENOPE01328cam0 2200301 450 E60020000778420210616104559.020041120d1947 |||||ita|0103 baitaIT<<La >>filosofia contemporanea. vol. I, La filosofia tedesca - La filosofia francese. vol. II, Germania - Francia - Inghilterra - America - ItaliaGuido De RuggeroV ed.BariLaterza19472 voll.22 cmBiblioteca di cultura moderna001LAEC000162592001 *Biblioteca di cultura modernaDe Ruggiero, GuidoA60020002637307011779ITUNISOB20210616RICAUNISOBUNISOB000|Coll|1|bis3020UNISOB000|Coll|1|bis3019E600200007784M 102 Monografia moderna SBNM000|Coll|1|bis000037-1SI3020acquistopregresso2UNISOBUNISOB20041120101955.020210616104548.0Spinosa000|Coll|1|bis000037-2SI3019acquistobethbUNISOBUNISOB20201111123758.020210616104559.0SpinosaFilosofia contemporanea. vol. I, La filosofia tedesca - La filosofia francese. vol. II, Germania - Francia - Inghilterra - America - Italia1760950UNISOB04942nam 22007215 450 991062430990332120251009103400.03-031-08881-610.1007/978-3-031-08881-0(MiAaPQ)EBC7133434(Au-PeEL)EBL7133434(CKB)25299348800041(PPN)266354556(DE-He213)978-3-031-08881-0(OCoLC)1351750849(EXLCZ)992529934880004120221107d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierVoltage-Gated Calcium Channels /edited by Gerald Werner Zamponi, Norbert Weiss1st ed. 2022.Cham :Springer International Publishing :Imprint: Springer,2022.1 online resource (705 pages)Physics and Astronomy SeriesPrint version: Zamponi, Gerald Werner Voltage-Gated Calcium Channels Cham : Springer International Publishing AG,c2022 9783031088803 Includes bibliographical references and index.1. Measuring and manipulating calcium -- 2. Structure, function and subunit assembly of VGCC -- 3. Splice variation and RNA editing of VGCCs -- 4. Mechanisms of calcium channel permeation -- 5. Regulation by beta subunits -- 6. Regulation by alpha2 delta subunits -- 7. VGCCs in invertebrates -- 8. Modulation by GPCRs and second messengers -- 9. Trafficking of VGCCs -- 10. Calcium regulation -- 11. Calcium channel complexes with other channels -- 12. Regulation of gene transcription by VGCCs -- 13. Lessons from knock-out and knock-in mice -- 14. VGCCs and synaptic transmission -- 15. Cardiovascular syste -- 16. Calcium channels and exocytosis in chromaffin cells -- 17. Calcium channels in the pancreas in health and disease -- 18. Skeletal muscle system -- 19. Auditory and visual systems -- 20. Calcium channels and pain transmission -- 21. Migraine -- 22. Epilepsy -- 23. Psychiatric disorders -- 24. Parkinson’s disease.-25. Reproductive system -- 26. Cancer -- 27. Molecular determinants of VGCC pharmacology -- 28. Interactions with peptide toxins -- 29. Clinical pharmacology and drug discovery.This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery. Provides a comprehensive update on the state of knowledge of voltage-gated calcium channels; Examines how calcium channels are pharmacologic targets in the treatment of epilepsy, hypertension, and pain; Explores the new, sophisticated imaging approaches that have increased our ability to measure calcium in live cells; Presents an understanding of the molecular mechanisms that govern calcium channel trafficking and distribution.Physics and Astronomy SeriesCytologyNeurosciencesHuman physiologyBiophysicsPharmacologyCell BiologyNeuroscienceHuman PhysiologyBiophysicsPharmacologyCytology.Neurosciences.Human physiology.Biophysics.Pharmacology.Cell Biology.Neuroscience.Human Physiology.Biophysics.Pharmacology.572.516572.3Zamponi Gerald W.Weiss NorbertMiAaPQMiAaPQMiAaPQBOOK9910624309903321Voltage-gated calcium channels3064947UNINA