01508cam0-2200457---450-99000335446020331620091130135700.00-07-019552-8000335446USA01000335446(ALEPH)000335446USA0100033544620091130d2001----|||y0itay0103----baengSG||||||||001yyHazardous waste managementMichael D. LaGrega, Phillip L. Buckingham, Jeffrey C. Evans2.ed.Boston [etc.]McGraw-Hill2001XXVI, 1202 p.ill.24 cmMcGraw-Hil Series in water resources and environmental engineering2001McGraw-Hil Series in water resources and environmental engineering2001001-------2001RifiutiGestioneBNCF363.72876LAGREGA,Michael D.745482BUCKINGHAM,Phillip L.745483EVANS,Jeffrey C.745484ITSALBCISBD990003354460203316363.72 LAG 121540 Ing.363.72 LAG00261012BKECOFIORELLA9020091130USA011353FIORELLA9020091130USA011354FIORELLA9020091130USA011356FIORELLA9020091130USA011356FIORELLA9020091130USA011357Hazardous waste management1486844UNISA03736nam 2200445z- 450 991013708890332120210212(CKB)3710000000824751(oapen)https://directory.doabooks.org/handle/20.500.12854/57569(oapen)doab57569(EXLCZ)99371000000082475120202102d2015 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRadiation-induced and oxidative DNA damagesFrontiers Media SA20151 online resource (93 p.)Frontiers Research Topics2-88919-660-7 DNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques.ChemistrybicsscAnalytical ChemistryDNA lesionsOxidative damagesPhotochemistry and PhotophysicsPhotosensitizationRadiation induced lesionssimulation and modelingspectroscopyChemistryElise Dumontauth1305911Antonio MonariauthChryssostomos ChatgilialogluauthBOOK9910137088903321Radiation-induced and oxidative DNA damages3028008UNINA01356nam0 22003253i 450 TO0141542720251003044411.0075910296120091217d2003 ||||0itac50 baengusz01i xxxe z01nLongitudinal qualitative researchanalyzing change through timeJohnny SaldañaWalnut Creek [etc.]Altamira©2003XI, 199 p.23 cmBibliogr.: p. 175-185.Scienze socialiRicercaMetodiFIRCFIC171994E001.4RICERCA. METODI STATISTICI14MetodoMetodiMetodoSantaña, JohnnyTO0V549987070771801ITIT-00000020091217IT-BN0095 NAP 01POZZO LIB.Vi sono collocati fondi di economia, periodici di ingegneria e scienze, periodici di economia e statistica e altri fondi comprendenti documenti di economia pervenuti in dono. TO01415427Biblioteca Centralizzata di Ateneo1 v.1 v. 01POZZO LIB.ECON MON 622 0101 0000194155E VMA 1 v. precedente collocazione sez. DASES B 1553B 2009121720091217 01Longitudinal qualitative research1575250UNISANNIO