04340nam 2201201z- 450 991059507080332120231214133143.0(CKB)5680000000080822(oapen)https://directory.doabooks.org/handle/20.500.12854/92074(EXLCZ)99568000000008082220202209d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDiagnostic or Therapeutic Strategies for Pregnancy ComplicationsBaselMDPI Books20221 electronic resource (238 p.)3-0365-4877-7 3-0365-4878-5 It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an increased risk of neurodevelopmental and cardiovascular diseases. Over the past decade, numerous groups have investigated the use of new and/or existing drugs to either prolong gestation, such as in cases of threatened preterm labour; alleviate hypertension in preeclampsia; or promote adequate blood flow and nutrient delivery to the placenta to facilitate growth in IUGR. The overarching goal has been to promote healthier pregnancies and neonatal health, but it has been difficult to translate this work into the clinical setting, with problems in terms of drug delivery, specificity, and importantly, the early diagnostic capacities for complications in pregnancy. This book focuses on the early detection, potential novel therapeutic targets, risk factors, maternal outcomes, and long-term consequences of this critical problem.Medicinebicsscultrasonographyelastographyuterine cervixterm pregnancyparturitiongenotypingpreeclampsiaMMP-9MMP-2SNPstocolyticpreterm birthpreterm laborneonateprematuritypregnancytherapeuticprogesteronefetussex as a biological variablesex differencespregnancy complicationsplacentaprenatal diagnosisfetal growth restrictionmiscarriagechorio-deciduitisgradeamnionitisacute histologic chorioamnionitisintra-amniotic inflammatory responsebeta-blockerendothelial dysfunctioncardiovascular diseasepregnancy lossimmunologyvascular endothelial growth factorgalectin-9interleukin-4proteomicsurinebiomarkersIBP4SHBGRPLNK cellssildenafilPDE5AVEGF-Aangiotensininfantnewbornfemaleabruptio placentaeApgar scorepregnant womengestational ageIL-1 blockadeanakinracanakinumabhumaninflammationfetal growth restriction (FGR)intra-uterine growth restriction (IUGR)SPINT1HAI-1stillbirthplacental insufficiencyhistopathologycardiovascular riskpostpartum screeningMedicineHeazell Alexanderedt1328470Girard SylvieedtHeazell AlexanderothGirard SylvieothBOOK9910595070803321Diagnostic or Therapeutic Strategies for Pregnancy Complications3038575UNINA01523nam0 22003613i 450 TO0132841820251003044411.0284394000120220802d1997 ||||0itac50 bafrefrz01i xxxe z01nz01ncRDAcarrierˆL'‰Édit de Nantestexte presenté et annoté par Janine Garrissonavant propos de Jean-Pierre BabelonBiarritzÉditions Atlantica[1997!136 p. c. geogr.21 cmSul front.: Société Henry IV.FranciaFIRCFIC019655IUgonottiFIRLO1C312460EEditto di Nantes. 1598FIRLO1C405738E274CRISTIANESIMO IN EUROPA.23Garrisson, JanineMILV002601Babelon, Jean PierreRAVV015691Francia <Regno>PUVV3280280704161ITIT-00000020220802IT-BN0095 NAP 01POZZO LIB.Vi sono collocati fondi di economia, periodici di ingegneria e scienze, periodici di economia e statistica e altri fondi comprendenti documenti di economia pervenuti in dono. TO01328418Biblioteca Centralizzata di Ateneo1 v. 01POZZO LIB.ECON MON 7221 0101 0700231195E VMA 1 v. (Precedente collocazione 23 Ec 119)B 2022080220220802 01Édit de Nantes2902175UNISANNIO