03864nam 2200769Ia 450 991014062010332120200520144314.09786612551598978128255159612825515909780470588284047058828497804705882770470588276(CKB)2670000000009572(EBL)487637(OCoLC)587063581(SSID)ssj0000367271(PQKBManifestationID)11923653(PQKBTitleCode)TC0000367271(PQKBWorkID)10418481(PQKB)10611745(MiAaPQ)EBC487637(Au-PeEL)EBL487637(CaPaEBR)ebr10366682(CaONFJC)MIL255159(OCoLC)495594915(FINmELB)ELB178856(Perlego)2788162(EXLCZ)99267000000000957220091223d2010 uy 0engurcn|||||||||txtccrVanilloid receptor TRPV1 in drug discovery targeting pain and other pathological disorders /edited by Arthur Gomtsyan, Connie R. Faltynek1st ed.Hoboken, NJ Wileyc20101 online resource (486 p.)Description based upon print version of record.9780470175576 0470175575 Includes bibliographical references and index.VANILLOID RECEPTOR TRPV1 IN DRUG DISCOVERY; CONTENTS; PREFACE AND ACKNOWLEDGMENTS; FOREWORD; CONTRIBUTORS; PART I INTRODUCTION TO THE TRP CHANNELS; 1 TRP Channels and Human Diseases; 2 Role of TRP Channels in Pain: An Overview; 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals; 4 TRPV1 Genetics; PART II ROLE FOR TRPV1 IN PAIN STATES; 5 TRPV1 and Inflammatory Pain; 6 Role of TRPV1 Receptors in Osteoarthritic Pain; 7 TRPV1 and Bone Cancer Pain; 8 TRPV1 in Visceral Pain and Other Visceral Disorders; 9 TRPV1 Receptors and Migraine10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS; 11 Aryl-Urea Class and Related TRPV1 Antagonists; 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists; 13 TRPV1 Agonist Approaches for Pain Management; PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION; 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?; 15 The Role of TRPV1 in Respiratory Diseases; 16 The Role of TRPV1 in Diabetes; AFTERWORDINDEXExamines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it ""the holy grail"" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1AnalgesicsDrugsDesignNociceptorsInflammationAnalgesics.DrugsDesign.Nociceptors.Inflammation.615.783615/.783Gomtsyan Arthur978875Faltynek Connie R978876MiAaPQMiAaPQMiAaPQBOOK9910140620103321Vanilloid receptor TRPV1 in drug discovery2231132UNINA01539nam0 22003253i 450 PUV035184020251003044312.00198774591019877496619980313d1996 ||||0itac50 baenggbz01i xxxe z01nInformation and communication technologiesvision and realitiesedited by William H. Dutton with the assistance of Malcolm PeltuOxfordOxford University Press1996XX, 464 p.24 cm.COMUNICAZIONEPROGRESSO TECNOLOGICOASPETTI SOCIO-ECONOMICIFIRMILC110721IINFORMAZIONEINNOVAZIONE TECNOLOGICAASPETTI SOCIO-ECONOMICIFIRMILC113717I303.48PROCESSI SOCIALI. Cause del cambiamento14Peltu, MalcolmMILV001483Dutton, William H.UR1V000639ITIT-00000019980313IT-BN0095 NAP 01POZZO LIB.Vi sono collocati fondi di economia, periodici di ingegneria e scienze, periodici di economia e statistica e altri fondi comprendenti documenti di economia pervenuti in dono. PUV0351840Biblioteca Centralizzata di Ateneo1 v.1 v. 01POZZO LIB.ECON MON 784 0101 0000001035E VMA 1 v. (rist. 2001) precedente collocazione sez. DASES B 0065B 2007073020070730 01Information and Communication Technologies2929612UNISANNIO