04116nam 2200625 450 991013720560332120230621140722.09782889192793(ebook)(CKB)3710000000526086(SSID)ssj0001680364(PQKBManifestationID)16496324(PQKBTitleCode)TC0001680364(PQKBWorkID)15028535(PQKB)11675584(WaSeSS)IndRDA00056395(oapen)https://directory.doabooks.org/handle/20.500.12854/53850(EXLCZ)99371000000052608620160829d2015 uy |engurc|#---|||||txtrdacontentcrdamediacrrdacarrierMolecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases /Frontiers Media SA2015France :Frontiers Media SA,20151 online resource (163 pages) illustrations; digital, PDF file(s)Frontiers Research TopicsBibliographic Level Mode of Issuance: MonographIncludes bibliographical references.Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity.Microbiology & ImmunologyHILCCBiologyHILCCHealth & Biological SciencesHILCCsecretory lysosomesNK cellshemophagocytic histiocytosisimmune therapygranzymelytic granulesCytotoxicityanti-tumor responseImmunological SynapsePerforinMicrobiology & ImmunologyBiologyHealth & Biological SciencesKonrad Krzewskiauth1364357Krzewski KonradBryceson YenanPQKBUkMaJRU9910137205603321Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases3385560UNINA04262nam 22007455 450 991096319990332120210108152631.09780226117577022611757X10.7208/9780226117577(CKB)3710000000089343(EBL)1635755(SSID)ssj0001108129(PQKBManifestationID)12392587(PQKBTitleCode)TC0001108129(PQKBWorkID)11086396(PQKB)11313286(StDuBDS)EDZ0000708043(DE-B1597)524823(OCoLC)870951080(DE-B1597)9780226117577(MiAaPQ)EBC1635755(Perlego)1851799(EXLCZ)99371000000008934320200424h20142014 fg engur|n|---|||||txtccrEmpire of Religion Imperialism and Comparative Religion /David ChidesterChicago : University of Chicago Press, [2014]©20141 online resource (398 p.)Description based upon print version of record.9780226117263 022611726X Includes bibliographical references and index.Frontmatter -- Contents -- Preface -- Chapter One. Expanding Empire -- Chapter Two. Imperial, Colonial, and Indigenous -- Chapter Three. Classify and Conquer -- Chapter Four. Animals and Animism -- Chapter Five. Myths and Fictions -- Chapter Six. Ritual and Magic -- Chapter Seven. Humanity and Divinity -- Chapter Eight. Thinking Black -- Chapter Nine. Spirit of Empire -- Chapter Ten. Enduring Empire -- Notes -- IndexHow is knowledge about religion and religions produced, and how is that knowledge authenticated and circulated? David Chidester seeks to answer these questions in Empire of Religion, documenting and analyzing the emergence of a science of comparative religion in Great Britain during the second half of the nineteenth century and its complex relations to the colonial situation in southern Africa. In the process, Chidester provides a counterhistory of the academic study of religion, an alternative to standard accounts that have failed to link the field of comparative religion with either the power relations or the historical contingencies of the imperial project. In developing a material history of the study of religion, Chidester documents the importance of African religion, the persistence of the divide between savagery and civilization, and the salience of mediations-imperial, colonial, and indigenous-in which knowledge about religions was produced. He then identifies the recurrence of these mediations in a number of case studies, including Friedrich Max Müller's dependence on colonial experts, H. Rider Haggard and John Buchan's fictional accounts of African religion, and W. E. B. Du Bois's studies of African religion. By reclaiming these theorists for this history, Chidester shows that race, rather than theology, was formative in the emerging study of religion in Europe and North America. Sure to be controversial, Empire of Religion is a major contribution to the field of comparative religious studies.Great Britain -- Colonies -- AfricaImperialism -- Religious aspectsSouth Africa -- ReligionImperialismReligious aspectsReligionHILCCPhilosophy & ReligionHILCCAfrican ReligionsHILCCSouth AfricaReligionGreat BritainColoniesAfricaGreat Britain -- Colonies -- Africa.Imperialism -- Religious aspects.South Africa -- Religion.ImperialismReligious aspects.ReligionPhilosophy & ReligionAfrican Religions200.9171200.9171241Chidester David, authttp://id.loc.gov/vocabulary/relators/aut658698DE-B1597DE-B1597BOOK9910963199903321Empire of Religion4367517UNINA01315oam 2200277z- 450 99101487845033210-8254-8619-X(CKB)3710000000922906(VLeBooks)9780825486197(Exl-AI)993710000000922906(EXLCZ)99371000000092290620210505c2015uuuu -u- -engFilipensesEditorial Portavoz1 online resource (1 p.)En las paginas de estos comentarios expositivos no se percibe solamente un gran conocimiento de la Biblia, sino un amor y un celo profundos por la Palabra de Dios y por el Dios de la Palabra. John MacArthur hace una valiosa contribucion a la interpretacion y aplicacion del texto biblico que se refleja en una exegesis cuidadosa, una gran familiaridad con el escritor inspirado y su contexto, asi como en variadas explicaciones e ilustraciones practicas. Representa un excelente recurso para la preparacion de sermones, el estudio personal y la vida devocional.Biblical teachingGenerated by AIChristian lifeGenerated by AIBiblical teachingChristian lifeMacArthur John837434BOOK9910148784503321Filipenses4175691UNINA02774nam0 2200529 i 450 LO1091338820251003044213.08873950515IT2005-6176 20050323d2004 ||||0itac50 baitaitz01i xxxe z01nStoria dei progetti di riforma della pubblica amministrazioneFrancia e Italia 1943-1948Giovanni FocardiBolognaBononia university press2004359 p.21 cm.Lavoro e territorio1001LO109133892001 Lavoro e territorio1ItaliaAmministrazione pubblicaRiforma1943-1948FIRCFIC153288IFranciaAmministrazione pubblicaRiforma1940-1946FIRCFIC153289I342.4506POTERE ESECUTIVO. ITALIA20351.45AMMINISTRAZIONE. ITALIA21FR/2723.2GOVERNO PUBBLICA AMMINISTRAZIONE FORZE ARMATE FRANCIA VICHY 1940-1945RFR/342.2GOVERNO PUBBLICA AMMINISTRAZIONE FORZE ARMATE FRANCIA 1945-1968RIT/2721.2GOVERNO PUBBLICA AMMINISTRAZIONE FORZE ARMATE ITALIA 1943-1945RIT/3420.1PRIMO DOPOGUERRA ITALIA 1945-1948RIT/3422.3PUBBLICA AMMINISTRAZIONE ITALIA 1945-1968RPubblica amministrazioneOrgani della pubblica amministrazioneOrgani ordinariRiforma protestantePubblica amministrazioneOrgani della pubblica amministrazioneOrgani ordinariRiforma protestanteAmministrazione pubblicaPubblica amministrazioneAmministrazione pubblicaOrgani della pubblica amministrazioneAmministrazione pubblicaOrgani ordinariRiformaRiforma protestanteAmministrazione pubblicaPubblica amministrazioneAmministrazione pubblicaOrgani della pubblica amministrazioneAmministrazione pubblicaOrgani ordinariRiformaRiforma protestanteFocardi, GiovanniLO1V300155070437562ITIT-00000020050323IT-BN0095 NAP 01POZZO LIB.Vi sono collocati fondi di economia, periodici di ingegneria e scienze, periodici di economia e statistica e altri fondi comprendenti documenti di economia pervenuti in dono. LO10913388Biblioteca Centralizzata di Ateneo1 v. 01POZZO LIB.ECON MON 4708 01C 0800203325E VMA 1 v. (Precedente collocazione: EC C 20 332)B 2013032820130328 01Storia dei progetti di riforma della pubblica amministrazione64060UNISANNIO