00918nam a22002413i 450099100365352970753620040521165712.0040802s1979 it |||||||||||||||||ita b1310696x-39ule_instARCHE-105957ExLBiblioteca InterfacoltàitaA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l.853.9Nobili, Guido165971Senza bussola!... /Guido Nobili[Roma] :A. Curcio,stampa 1979247 p. ;21 cmI classici della narrativa / collana diretta da Libero Bigiaretti.b1310696x02-04-1405-08-04991003653529707536LE002 Fondo Giudici L 165312002000349415le002C. 1-E0.00-no 00000.i1374143305-08-04Senza bussola!..306839UNISALENTOle00205-08-04ma -itait 0105038nam 2200601Ia 450 99621829220331620230607221528.01-281-32161-397866113216110-470-76007-90-470-75980-1(CKB)1000000000402961(EBL)351295(OCoLC)298254454(SSID)ssj0000204758(PQKBManifestationID)11197096(PQKBTitleCode)TC0000204758(PQKBWorkID)10192115(PQKB)11441279(MiAaPQ)EBC351295(EXLCZ)99100000000040296120000214d2001 uy 0engur|n|---|||||txtccrMolecular and genetic analysis of human traits[electronic resource] /Gustavo MaroniMalden, MA Blackwell Sciencec20011 online resource (296 p.)Description based upon print version of record.0-632-04369-5 Includes bibliographical references and index.Contents; PREFACE; CHAPTER 1 The Inheritance of Simple Mendelian Traits in Humans; DETECTING MENDELIAN INHERITANCE IN HUMANS; Test-Crosses and Pure Lines versus Pedigrees and Inferred Genotypes; Box 1.1 Early observations of Mendelian inheritance in humans; PATTERNS OF INHERITANCE AND EXAMPLES; Autosomal Dominant Traits; Autosomal Recessive Traits; X-Linked Recessive Traits; THE USE OF PEDIGREES TO PREDICT THE RESULTS OF MATINGS; Probability of Individual Genotypes; Probability of Group Outcomes; GATHERING DATA TO TEST THE MODE OF INHERITANCE OF A TRAITPooling Data from Many Families and Ascertainment ErrorsAscertainment errors in studies of dominant traits; Ascertainment errors in studies of recessive traits; INHERITANCE OF MULTIPLE TRAITS: INDEPENDENT ASSORTMENT AND LINKAGE; Determination of Linkage from Human Pedigrees; Genetic Recombination and LOD Scores; Informative and Noninformative Matings; Neutral Polymorphisms, Marker Loci, and Genetic Maps; Box 1.2 Internet sites; The use of protein products to define marker loci; The use of directly detected DNA differences as marker lodEXAMPLE 1.1 Linkage of the Huntington's disease gene to an RFLPCONCLUSION; EXERCISES; REFERENCES; CHAPTER 2 Hereditary Traits That Do Not Show a Simple Mendelian Pattern; SINGLE-GENE TRAITS LACKING A SIMPLE MENDEUAN PATTERN; Variable Exprrssiviy and Incomplete Penetrance; Complementation; Phenocopies and Pleiotropy; QUANTITATIVE TRAITS; Multiple Alleles; Polygenic Inheritance; Major and Minor Genes; COMPLEX TRAITS; Epidemiological Analysis of Complex Traits; Liability; Family Clustering; Identical Twins; LOCALIZATION OF GENES RESPONSIBLE FOR COMPLEX AND QUANTITATIVE TRAITSLinkage Analysis of Complex TraitsAffected Pedigree Member (APM) or Allele-Sharing Methods; Example 2.1. Familial psoriasis; Example 2.2. Familial breast cancer; Analysis of quantitative trait loci by allele-sharing methods; Example 2.3. Insulin-dependent diabetes mellitus; Example 2.4. Male homosexuality; Allelic Association; Example 2.5. Dyslexia; Candidate Gene; Example 2.6. Nonsyndromal autosomal recessive deafness; Example 2.7. Neuroticism and genes for serotonin metabolism; CONCLUSION: NATURE VERSUS NURTURE; EXERCISES; REFERENCES; CHAPTER 3 Genome Organization IUNEXPRESSED DNA, REPETITIVE AND UNIQUE SEQUENCESClustered, Highly Repetitive Sequences; The main families of highly repetitive sequences; Example 3.1. The a family of highly repetitive DNA; Small-Cluster, Intermediately Repeated DNA; Minisatellite DNA; Microsatellite DNA; Dispersed, Intermediately Repeated Sequences; Viral retrotransposons; Nonviral retrotransposons: Alu, L1, and processed pseudogenes; Unique Sequence DNA; EXPRESSED DNA, GENES AND GENE FAMILIES; The Organization of RNA Polymerase I1 Genes: Intmns and Exons; Box 3.1. Internet sites; Example 3.2. CollagenExample 3.3. Cystic fibrosisMolecular and Genetic Analysis of Human Traits will address the science student human genetics market. Although incorporating two basic themes: how do we establish that a trait is hereditary, and how is the human genome organized, it will also address relevant clinical examples and key related ethical issues. New attractive features have been added, including a chapter project, and end of chapter exercises which rely on real data. Each chapter includes end of chapter exercises, and references. In-text examples and internet references are cited. Most figurHuman geneticsMedical geneticsHuman genetics.Medical genetics.599.935Maroni Gustavo870949MiAaPQMiAaPQMiAaPQBOOK996218292203316Molecular and genetic analysis of human traits2002576UNISA