01077nam a2200265 i 4500991002792479707536150624s2014 it 001 0 ita 9788884029171b14232972-39ule_instDip.to di Storia, Società e Studi sull'Uomoita909.09822 Cardini, Franco37956Incontri (e scontri) mediterranei :il Mediterraneo come spazio di contatto tra culture e religioni diverse /Franco CardiniRoma :Salerno,2014125 p. ;17 cmAstrolabio ;7Include riferimenti bibliografici (p. 111-116) e indiceGeografia politicaPaesi mediterraneiPaesi mediterraneiStoria.b1423297221-10-1524-06-15991002792479707536LE023 909.09 CAR 1 1 12023000140369le023pE8.90-l- 01010.i1570067720-10-15Incontri (e scontri) mediterranei255331UNISALENTOle02224-09-15ma -itait 0004874nam 22006495 450 991037391910332120250609111005.0981-13-8719-210.1007/978-981-13-8719-7(CKB)4100000009837033(DE-He213)978-981-13-8719-7(MiAaPQ)EBC5975959(PPN)258059257(MiAaPQ)EBC5975518(EXLCZ)99410000000983703320191109d2019 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierProtein Allostery in Drug Discovery /edited by Jian Zhang, Ruth Nussinov1st ed. 2019.Singapore :Springer Singapore :Imprint: Springer,2019.1 online resource (XII, 384 p. 103 illus., 82 illus. in color.)Advances in Experimental Medicine and Biology,0065-2598 ;1163981-13-8718-4 Chapter 1. Allostery in Drug Development -- Chapter 2. Dynamic Protein Allosteric Regulation and Disease -- Chapter 3. Protein Allostery in Rational Drug Design -- Chapter 4. Progress in Allosteric Database -- Chapter 5. Correlation between Allosteric and Orthosteric Sites -- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators -- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins -- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands -- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network -- Chapter 10. GPCR Allosteric Modulator Discovery -- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors -- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs) -- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins -- Chapter 15. Engineering Allostery into Proteins.The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. .Advances in Experimental Medicine and Biology,0065-2598 ;1163Pharmaceutical technologyProteinsBiomedical engineeringPharmaceutical Sciences/Technologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21010Protein Sciencehttps://scigraph.springernature.com/ontologies/product-market-codes/L14040Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050Biomedical Engineering/Biotechnologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B24000Tecnologia farmacèuticathubLlibres electrònicsthubPharmaceutical technology.Proteins.Biomedical engineering.Pharmaceutical Sciences/Technology.Protein Science.Protein Structure.Biomedical Engineering/Biotechnology.Tecnologia farmacèutica615.19Zhang Jianedthttp://id.loc.gov/vocabulary/relators/edtNussinov Ruthedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910373919103321Protein Allostery in Drug Discovery1965983UNINA