00916nam a2200241 i 450099100254935970753620020508202146.0010704s1964 de ||| | lat b1102656x-39ule_instPARLA164876ExLDip.to Filosofiaita296.16Reuchlin, Johann324791De verbo mirifico, 1494; De arte cabalistica, 1517 :faksimile-Neudruck in einem Band /Johannes ReuchlinStuttgart-Bad Cannstatt :Frommann,1964271 p. :ill. ;19 cm.Cabala.b1102656x21-09-0628-06-02991002549359707536LE005IF II A 171LE005IFA-1061le005-E0.00-l- 00000.i1114680128-06-02De verbo mirifico, 1494; De arte cabalistica, 1517862647UNISALENTOle00501-01-01ma -latde 0104879nam 22006735 450 991036993530332120200703054027.03-030-23417-710.1007/978-3-030-23417-1(CKB)4100000009758981(DE-He213)978-3-030-23417-1(MiAaPQ)EBC5972835(PPN)24282577X(EXLCZ)99410000000975898120191105d2020 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierCentral Nervous System Metastases /edited by Manmeet Ahluwalia, Philippe Metellus, Riccardo Soffietti1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (XIII, 421 p. 45 illus., 37 illus. in color.) 3-030-23416-9 PREFACE -- I Epidemiology -- II Pathology and Biology -- 1 Pathology of brain metastases -- 2 Translationnal approaches -- 3 Molecular mechanisms driving brain metastases development -- 4 Genomics characterization of BM -- 5 BM cell partners and tumor microenvironment -- 6 Experimental models of Brain Metastases -- III Clinical presentation and symptom management -- 7 Clinical presentation -- 8 Epilepsy in CNS metastases -- 9 Safety, tolerability and use of steroids in CNS metastasis patients -- 10 Thrombo-embolic complications in BM patients -- IV Imaging -- 11 BM diagnosis and monitoring -- 12 Metabolic imaging of BM -- 13 Radiation necrosis and progression assessment and definition -- V Surgery -- 14 Modern surgical techniques -- 15 Quality of surgical resection assessment -- 16 Indications and emerging concepts in the era molecular biology -- VI Radiation Therapy -- 17 Stereotatic radiosurgery -- 18 WBRT -- 19 Combined radiation therapy and systemic treatment -- VII Systemic treatment -- 20 Lung -- 21 Breast.-. 22 Melanoma -- 23 Miscellaneous -- VIII Neurocognition and QoL -- IV Leptomeningeal disease -- X Prevention/Prohylaxis strategies -- XI Prognosis and prognostic models -- XII Clinical trials / Endpoints and outcome assessment. .This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.Nervous systemSurgeryRadiotherapyOncologyCancerResearchQuality of lifeNeurosurgeryhttps://scigraph.springernature.com/ontologies/product-market-codes/H39000Radiotherapyhttps://scigraph.springernature.com/ontologies/product-market-codes/H29056Oncologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H33160Cancer Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/B11001Quality of Life Researchhttps://scigraph.springernature.com/ontologies/product-market-codes/X23000Nervous systemSurgery.Radiotherapy.Oncology.CancerResearch.Quality of life.Neurosurgery.Radiotherapy.Oncology.Cancer Research.Quality of Life Research.617.48616.9948Ahluwalia Manmeetedthttp://id.loc.gov/vocabulary/relators/edtMetellus Philippeedthttp://id.loc.gov/vocabulary/relators/edtSoffietti Riccardoedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK9910369935303321Central Nervous System Metastases2083300UNINA