00911nam a2200241 i 450099100150651970753620020502180610.0000124s1999 it ||| | ||| b10858738-39ule_instLE02370321ExLDip.to Studi StoriciitaBarberi, Augusto537378L'apprendimento della costituzione :(1947-1957) /a cura di Augusto Barbera, Marco Cammelli, Paolo PombeniMilano :Franco Angeli,1999CostituzioneItaliaCammelli, MarcoPombeni, Paolo.b1085873821-09-0628-06-02991001506519707536LE023 945.0924 BAR 1 112023000046739le023-E0.00-l- 01010.i1096867228-06-02Apprendimento della costituzione918087UNISALENTOle02301-01-00ma -engit 2104930nam 2201165z- 450 991057687890332120220621(CKB)5720000000008386(oapen)https://directory.doabooks.org/handle/20.500.12854/84555(oapen)doab84555(EXLCZ)99572000000000838620202206d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvance in the Treatment of Pediatric LeukemiaBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (300 p.)3-0365-4167-5 3-0365-4168-3 The book gives an overview on the progress that has been made in the treatment of acute lymphoblastic leukemia (ALL), of acute and chronic myeloid leukemia (AML, CML) and of juvenile myelomonocytic leukemia (JMML). Leukemia is the most common malignant disease in children, and 80% of patients are diagnosed with ALL and 15-20% with AML, whereas CML and JMML are rather rare. Although ALL was considered an incurable disease until the early 1960s, with the availability of cytotoxic drugs and the start of clinical multicenter studies, ALL has become an almost curable disease with a survival rate exceeding 90 % in high-income countries. These impressive results have mainly been achieved by a deeper understanding of the genomic landscape of the disease and the introduction of risk stratifications based on genetic features and response to chemotherapy as determined by the presence or absence of minimal residual disease (MRD). Immunotherapies including bispecific T-cell Engagers (BiTEs), Chimeric Antigen Receptor (CAR) T cells, monoclonal antibodies and improvements in the outcome of allogeneic stem cell transplantation (HSCT) have shown impressive results in chemorefractory or relapsed patients, and it is anticipated that the cure rate can be further increased. For countries with less resources, therapies have to be adapted to increase survival as well. This book also updates on the progress made in the treatment of AML. As in ALL, risk classification based on genetic factors and response to chemotherapy is most important for therapy guidance. The book also provides updates and guidance for the treatment of CML and JMML.ChemistrybicsscResearch & information: generalbicssc5-azacitidineABCC4acute lymphoblastic leukemiaacute myeloid leukemiaacute pancreatitisADCadvancesALLallogeneic stem cell transplantationalternative donorsAMLantibodyantibody-drug conjugateB-ALLBCL11BBCP-ALLbispecific T-cell engager (BiTE)CD19CFTRchildhood acute lymphoblastic leukemiachildrenchronic myeloid leukemiaCMLconditioning regimenCOVID-19diagnosisDUX4evolution of CAR T cellsFc-engineeringFDA-approved CAR productsfuture directions of CAR T cell therapygenomehematopoietic stem cell transplantationIKZF1immunizationsimmunotherapyjuvenile myelomonocytic leukemiaL-asparaginaseleukemialimitations and complications of CAR T cell therapylow-risk ALLlymphoblastic leukemiaminimal residual diseasemyelodysplastic/myeloproliferative disordersn/aNOTCH1NUTM1other extramedullary relapsePAX5pediatricpediatric leukemiaPh-likepolymorphismprognosisRAS signalingrisk-stratified treatmentSNVT-ALLtargeted therapyTcR versus CARTRAILtranscriptometreatmenttreatment related toxicitytyrosine kinase inhibitorxenograftZNF384ChemistryResearch & information: generalHandgretinger Rupertedt1326310Handgretinger RupertothBOOK9910576878903321Advance in the Treatment of Pediatric Leukemia3037296UNINA