02059nam 2200385 450 991063398230332120230323212607.01-83969-108-5(CKB)4920000002066093(NjHacI)994920000002066093(EXLCZ)99492000000206609320230323d2021 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierEstrogen as a Contributing Factor to the Development of Lipedema /written by Sara Al-Ghadban, Mary L. Teeler and Bruce A. BunnellLondon :IntechOpen,2021.1 online resource (136 pages)1-83969-107-7 1. Introduction -- 2. Estrogens and estrogen receptors in lipedema -- 2.1 Estrogen and adipogenesis -- 2.2 Estrogen and inflammation -- 3. Potential hormonal therapy -- 4. Conclusion -- Acknowledgments -- Conflict of interest -- References.Lipedema is an underdiagnosed painful adipose tissue disorder that occurs almost exclusively in women, with onset manifesting at puberty or at times of hormonal change. Unlike many fat disorders, diet and exercise have little to no impact on the prevention or progression of this disease. Estrogens control the distribution of body fat and food intake, regulate leptin expression, increase insulin sensitivity, and reduce inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ERα) and ERβ. This review will focus on understanding the role of estrogen in the pathogenesis of the disease and envisage potential hormonal therapy for lipedema patients.EstrogenEstrogen.573.44Al-Ghadban Sara1348886Bunnell Bruce A.Teeler Mary L.NjHacINjHaclBOOK9910633982303321Estrogen as a Contributing Factor to the Development of Lipedema3086577UNINA01392cam a22003378a 4500991000946829707536101115s1996 it a bf 001 0 ita d8885904459b13936293-39ule_instDip.to Fisicaeng 617.720LC RE46617.7The Wills eye manual :diagnosi e trattamento delle patologie oculari. Note cliniche e chirurgiche /R. Douglas Cullom, Jr., Benjamin Chang (eds.) ; ed. it. a cura di Massimo Barca2. ed. Milano :Fogliazza,c19963 v. (524 p. compless.) :ill. ;22 cm Eye DiseasesDiagnosisEye DiseasesTherapyEmergenciesCullom, R. DouglasChang, BenjaminBarca, Massimo.b1393629328-01-1415-11-10991000946829707536LE006 617.7 CULVol. 112006000165112le006gE23.24-l- 02020.i1519721915-11-10LE006 617.7 CULVol. 212006000165136le006gE23.24-l- 02020.i1519722015-11-10LE006 617.7 CULVol. 312006000165129le006gE23.24-l- 01010.i1519723215-11-10Wills eye manual250025UNISALENTOle00615-11-10ma -ita 4000902nam a2200241 i 4500991000548349707536100122s1989 it |01 0 ita 0390-6574b13873982-39ule_instDip.to SSCitaita330.945Istat374421I conti degli italiani :compendio della vita economica nazionale /Istituto nazionale di statisticaRoma :ISTAT,1989110 p. ;26 cmSupplemento all'Annuario Statistico ItalianoItaliaStatistica economica1980-1988.b1387398222-01-1022-01-10991000548349707536LE021 NGBISA16v. 2312021000175480le021-E0.00-l- 00000.i1506290922-01-10Conti degli italiani51969UNISALENTOle02122-01-10ma -itait 20