04117nam 22006615 450 99641827830331620200704030918.03-662-60792-110.1007/978-3-662-60792-3(CKB)4100000010770691(DE-He213)978-3-662-60792-3(MiAaPQ)EBC6154570(PPN)243222955(EXLCZ)99410000001077069120200331d2020 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierLikelihood and Bayesian Inference[electronic resource] With Applications in Biology and Medicine /by Leonhard Held, Daniel Sabanés Bové2nd ed. 2020.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2020.1 online resource (XIII, 402 p. 84 illus.) Statistics for Biology and Health,1431-87763-662-60791-3 This richly illustrated textbook covers modern statistical methods with applications in medicine, epidemiology and biology. Firstly, it discusses the importance of statistical models in applied quantitative research and the central role of the likelihood function, describing likelihood-based inference from a frequentist viewpoint, and exploring the properties of the maximum likelihood estimate, the score function, the likelihood ratio and the Wald statistic. In the second part of the book, likelihood is combined with prior information to perform Bayesian inference. Topics include Bayesian updating, conjugate and reference priors, Bayesian point and interval estimates, Bayesian asymptotics and empirical Bayes methods. It includes a separate chapter on modern numerical techniques for Bayesian inference, and also addresses advanced topics, such as model choice and prediction from frequentist and Bayesian perspectives. This revised edition of the book “Applied Statistical Inference” has been expanded to include new material on Markov models for time series analysis. It also features a comprehensive appendix covering the prerequisites in probability theory, matrix algebra, mathematical calculus, and numerical analysis, and each chapter is complemented by exercises. The text is primarily intended for graduate statistics and biostatistics students with an interest in applications.Statistics for Biology and Health,1431-8776Statistics BiostatisticsEcology BiomathematicsStatistics for Life Sciences, Medicine, Health Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/S17030Statistical Theory and Methodshttps://scigraph.springernature.com/ontologies/product-market-codes/S11001Biostatisticshttps://scigraph.springernature.com/ontologies/product-market-codes/L15020Bayesian Inferencehttps://scigraph.springernature.com/ontologies/product-market-codes/S18000Theoretical Ecology/Statisticshttps://scigraph.springernature.com/ontologies/product-market-codes/L19147Genetics and Population Dynamicshttps://scigraph.springernature.com/ontologies/product-market-codes/M31010Statistics .Biostatistics.Ecology .Biomathematics.Statistics for Life Sciences, Medicine, Health Sciences.Statistical Theory and Methods.Biostatistics.Bayesian Inference.Theoretical Ecology/Statistics.Genetics and Population Dynamics.570.15195Held Leonhardauthttp://id.loc.gov/vocabulary/relators/aut721217Sabanés Bové Danielauthttp://id.loc.gov/vocabulary/relators/autMiAaPQMiAaPQMiAaPQBOOK996418278303316Likelihood and Bayesian Inference2391152UNISA01020nam2 2200289 i 450 TO0080367620231121125841.0880205524620000613d1999 ||||0itac50 baitaitz01i xxxe z01n˜4: œAntologiaTorinoUTET©19992 v. 25 cm.001MIL04169722001 ˜Il œpensiero politicoidee, teorie, dottrinea cura di Alberto Andreatta ... [et al.]4001FER01741482000 4.1a cura di Alberto Andreatta, Artemio Enzo Baldini, Carlo Dolcini1001FER01741492000 4.2a cura di Gianfranco Pasquino4.2ITIT-0120000613IT-RM028 IT-RM0289 Biblioteca Universitaria AlessandrinaRM028 Biblioteca Statale A. BaldiniRM0289 TO00803676 01 04 07 52Antologia58498UNICAS04041nam 22006734a 450 991096312310332120200520144314.09786611730451978128173045912817304599780300129663030012966110.12987/9780300129663(CKB)1000000000471991(StDuBDS)BDZ0022171458(SSID)ssj0000201499(PQKBManifestationID)11184383(PQKBTitleCode)TC0000201499(PQKBWorkID)10245497(PQKB)11781868(StDuBDS)EDZ0000158001(MiAaPQ)EBC3420064(DE-B1597)485546(OCoLC)1024032087(DE-B1597)9780300129663(Au-PeEL)EBL3420064(CaPaEBR)ebr10170754(OCoLC)923589373(Perlego)1089666(EXLCZ)99100000000047199120010123d2001 uy 0engur|||||||||||txtccrMeselson, Stahl, and the replication of DNA a history of "the most beautiful experiment in biology" /Frederic Lawrence Holmes1st ed.New Haven, CT Yale University Press20011 online resource (1 online resource (xii, 503 p.) ) illBibliographic Level Mode of Issuance: Monograph9780300085402 0300085400 Includes bibliographical references (p. [449]-496) and index.Machine generated contents note: Chapter One The Replication Problem 11 -- Chapter Two Meselson and Stahl 49 -- Chapter Three Twists and Turs 75 -- Chapter Four Crossing Fields: Chemical Bonds to Biological Mutants 116 -- Chapter Five Dense Solutions 157 -- Chapter Six The Big Machine 183 -- Chapter Seven Working at High Speed 215 -- Chapter Eight The Unseen Band 272 -- Chapter Nine One Discovery, Three Stories 303 -- Chapter Ten An Extremely Beautiful Experiment 319 -- Chapter Eleven Centrifugal Forces 352 -- Chapter Twelve The Subunits of Semiconservative Replication 388 -- Chapter Thirteen Images of an Experiment 412 -- Chapter Fourteen Afterword 435.In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.DNA replicationExperimentsHistoryMolecular biologyExperimentsHistoryDNA replicationExperimentsHistory.Molecular biologyExperimentsHistory.572.8/6Holmes Frederic Lawrence726772MiAaPQMiAaPQMiAaPQBOOK9910963123103321Meselson, Stahl, and the replication of DNA4364680UNINA01202nam 2200301 c 450 99667085010331620241014115718.09783737017756(EXLCZ)994013704130004120241014d2024 u| |gertxtrdacontentcrdamediacrrdacarrierReligionsunterricht ›vor Ort‹ weiterentwickelnEmpirische Einblicke und Innovationsoptionen am Beispiel von Berufsschulen in BayernKonstantin Lindner, Henrik Simojoki, Laura Rudroff, Magdalena EndresGöttingenV&R unipress20241 Online-Ressource (206 Seiten)Religiöse Bildung kooperativBand 5Erscheint auch als Druck-Ausgabe Religionsunterricht ›vor Ort‹ weiterentwickeln 9783847117759 Religiöse Bildung kooperativ5Lindner Konstantin1976-aut1740511Simojoki Henrik1975-autRudroff Laura1990-autEndres Magdalena1990-autCH-ZuSLS UBE996670850103316Religionsunterricht ›vor Ort‹ weiterentwickeln4423513UNISA