05330nam 22006254a 450 991045355100332120200520144314.01-281-96088-89786611960889981-281-202-4(CKB)1000000000538137(EBL)1193374(SSID)ssj0000266086(PQKBManifestationID)11234828(PQKBTitleCode)TC0000266086(PQKBWorkID)10304894(PQKB)11738502(MiAaPQ)EBC1193374(WSP)00001981 (Au-PeEL)EBL1193374(CaPaEBR)ebr10255402(CaONFJC)MIL196088(OCoLC)560635766(EXLCZ)99100000000053813720080410d2008 uy 0engur|n|---|||||txtccrUsing animal models in biomedical research[electronic resource] a primer for the investigator /Pierce K.H. Chow, Robert T.H. Ng, Bryan E. OgdenHackensack, NJ World Scientificc20081 online resource (308 p.)Description based upon print version of record.981-270-663-1 Includes bibliographical references and index.1. Scientific considerations and choice of species. The rationale for the use of animal models in biomedical research / Pierce Chow. Experimental animal models in biomedical resarch / Robert Ng. Nonhuman primates as models in biomedical research / Jason Vilano and Bryan Ogden -- 2. Regulatory considerations in the use of animal models. Laws, regulations and guidelines for biomedical research in Singapore / Boon Theng Kuah. The functions of the institutional animal care and use committee / Pierce Chow. Responsibilities of principal investigators and research protocol evaluation / Hock Soo Ong. The 3r's, research variables and the use of alternatives / Hock Soo Ong. Use of statistics as determinant for number of animals used / Huihua Li. The advantages of accreditation with AAALAC / Bryan Ogden -- 3. Animal handling and surgical procedures. General handling, restraint, oral dosing/gavage and injections in laboratory animals / Bryan Ogden. Blood collection from laboratory animals / Jason Villano. Antibiotic coverage and therapy / Darvi Sergio. Animal preparation and transport / Robert Ng. Preparation and implementation of animal surgery / Robert Ng. Animal intubation / Robert Ng. Anaesthesia and maintenance of homeostasis / Robert Ng. animal euthanasia / Darvi Sergio. Rodent sentinel programme / Peik Khin Tan --4. Basic animal investigative methods. Bioimaging in animals / David Ng ... [et al.]. Histology sampling and techniques / In Chin Song. Animal tissue perfusion and preservation / Robert Ng. Animal cell culture / Peggy Yong and Kai Zhang. Application of microsurgical techniques in animal research / Bien Keem Tan ... [et al.] -- 5. Animal welfare considerations. Species specific caging configuration and design / Cindy Phua. Postoperative care and pain management / Jason Villano. animal feeds and nutritional requirements / Peik Khin Tan -- 6. Safety management of an animal facility. Occupational health and safety programme / Angela Goh. New employee and external users orientation / Inria Kurniawan Then. Radiation safety awareness in animal research / S. Somanesan. Emergency crisis management / Irene Kee. Zoonoses and laboratory animal allergies / Jason Villano -- 7. Supporting facilities design. clinical skills laboratory / Robert Ng. Animal research supporting laboratories / Robert Ng. animal research and housing facilities / Robert Ng -- 8. The development of comprehensive animal facilities in Singapore. History of the Department of Experimental Surgery as a reflection of translational research development in Singapore / Robert Ng -- Append. 1. Accredited laboratories for import of experimental animals -- Append. 2. Radiation safety data -- Append. 3. Anaesthesia for laboratory animals -- Append. 4. Analgesics and therapeutics for laboratory animals -- Append. 5. Passively transmitted zoonotic organisms.Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and required of all biomedical researchers. However, while both legislations and the practice of laboratory animal science have made great advances in the last decade and have impacted significantly on the use oAnimal models in researchMedicineResearchElectronic books.Animal models in research.MedicineResearch.610.284Chow Pierce K. H918693Ng Robert T. H918694Ogden Bryan E918695MiAaPQMiAaPQMiAaPQBOOK9910453551003321Using animal models in biomedical research2060266UNINA03929nam 2200433z- 450 99654036640331620231214141225.03-7489-0338-3(CKB)4100000009946726(oapen)https://directory.doabooks.org/handle/20.500.12854/62757(EXLCZ)99410000000994672620202102d2019 |y 0gerurmn|---annantxtrdacontentcrdamediacrrdacarrierWissen und BegründenEvidenz als umkämpfte Ressource in der WissensgesellschaftNomos Verlagsgesellschaft mbH & Co. KG20191 electronic resource (170 p.)3-8487-6223-4 Evidenz ist in der Wissensgesellschaft zu einer zentralen Ressource geworden. Gleichzeitig sind Aushandlungen um die Gültigkeit von Wissen ein im Laufe des 20. Jahrhunderts politisch brisanter werdendes Phänomen, das multiple Bereiche der Wissenschaft, der Technik, der Politik, der Medizin und der Gesellschaft prägt. Nicht erst die Diagnose eines „postfaktischen Zeitalters“ zeigt: Wissen wird in modernen Gesellschaften nicht per se akzeptiert, sondern Wissensakteure und -akteurinnen müssen überzeugen, um ihren Befunden Evidenz zu verleihen. Doch welche Praktiken wenden sie dazu an, wie wird die Gültigkeit von Wissen in verschiedenen Öffentlichkeiten ausgehandelt? Der Sammelband untersucht diese hier als Evidenzpraktiken verstandenen Dynamiken in interdisziplinärer Perspektive. Die Autoren und Autorinnen widmen sich dazu Beispielen aus der Medizin-, Kommunikations-, Wirtschafts-, Wissenschafts-, Technik- und Umweltweltforschung und sie verbinden dabei die Analyse der jüngsten Geschichte mit aktuellen Phänomenen. Mit Beiträgen von Helena Bilandzic, Tommaso Bruni, Sarah Ehlers, Stefan Esselborn, Sascha Dickel, Kay Felder, Mariacarla Gadebusch Bondio, Christine Haßauer, Susanne Kinnebrock, Magdalena Klingler, Emilia Lehmann, Sabine Maasen, Ruth Müller, Jutta Roosen, Helmuth Trischler, Andreas Wenninger, Fabienne Will, Karin Zachmann Evidence has become a key resource within our knowledge society. At the same time, during the course of the 20th century, negotiations on the validity of knowledge became a political and controversial phenomenon which has since shaped the multiple fields of science, technology, politics, medicine and society. As the diagnosis of a ‘post-factual age’ makes clear: knowledge will not be accepted in modern society per se; instead knowledge operators have to satisfy demands to give validity to their findings. But which practices should they apply for this purpose? How is the validity of knowledge negotiated in different public spheres? Using an interdisciplinary perspective, this anthology examines the dynamics of evidence practices. The authors cover examples from research in the fields of medicine, communication, the economy, science, technology and environmental studies. At the same time, they connect analysis from recent history with current phenomena. With contributions by Helena Bilandzic, Tommaso Bruni, Sarah Ehlers, Stefan Esselborn, Sascha Dickel, Kay Felder, Mariacarla Gadebusch Bondio, Christine Haßauer, Susanne Kinnebrock, Magdalena Klingler, Emilia Lehmann, Sabine Maasen, Ruth Müller, Jutta Roosen, Helmuth Trischler, Andreas Wenninger, Fabienne Will, Karin ZachmannWissen und Begründen WissensgesellschaftSoziologieEvidenzTechnikforschungBildungStudiumTechnikgeschichteinterdisziplinärEvidenzpraktikenIntelligenzZachmann Karinauth1091713Ehlers SarahauthBOOK996540366403316Wissen und Begründen3032099UNISA