03177nam 2200613Ia 450 991014440210332120170815112402.01-282-34275-497866123427520-470-72155-30-470-72156-1(CKB)1000000000579667(EBL)406495(OCoLC)476225856(SSID)ssj0000157792(PQKBManifestationID)11155896(PQKBTitleCode)TC0000157792(PQKBWorkID)10144410(PQKB)11411790(MiAaPQ)EBC406495(EXLCZ)99100000000057966720080707d2008 uy 0engur|n|---|||||txtccrFragment-based drug discovery[electronic resource] a practical approach /editors, Edward R. Zartler, Michael J. ShapiroChichester, U.K. John Wiley & Sons20081 online resource (297 p.)Description based upon print version of record.0-470-05813-7 Includes bibliographical references and index.Fragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; IndexFragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tiDrug developmentDrugsDesignLigands (Biochemistry)Electronic books.Drug development.DrugsDesign.Ligands (Biochemistry)615.19615/.19Zartler Edward924230Shapiro Michael(Michael J.)67246MiAaPQMiAaPQMiAaPQBOOK9910144402103321Fragment-based drug discovery2074092UNINA01441nam 2200433 450 99648315770331620231110233738.03-031-06788-6(CKB)5700000000100449(MiAaPQ)EBC7029179(Au-PeEL)EBL7029179(PPN)263897036(EXLCZ)99570000000010044920221227d2022 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierArtificial intelligence and securityPart II 8th International Conference, ICAIS 2022, Qinghai, China, July 15-20, 2022, proceedings /Xingming Sun [and three others], editorsCham, Switzerland :Springer International Publishing,[2022]©20221 online resource (701 pages)Lecture Notes in Computer Science ;v.133393-031-06787-8 Lecture Notes in Computer Science Artificial intelligenceCongressesCloud computingSecurity measuresCongressesArtificial intelligenceCloud computingSecurity measures006.3Sun XingmingMiAaPQMiAaPQMiAaPQBOOK996483157703316Artificial intelligence and security1999223UNISA04327nam 2200889 450 991078803910332120211005163608.00-8232-6632-X0-8232-6337-10-8232-6336-310.1515/9780823263363(CKB)2670000000582257(OCoLC)891382914(CaPaEBR)ebrary10930205(SSID)ssj0001355397(PQKBManifestationID)11863362(PQKBTitleCode)TC0001355397(PQKBWorkID)11346735(PQKB)11528991(StDuBDS)EDZ0001111276(MiAaPQ)EBC3239930(OCoLC)891351226(MdBmJHUP)muse37925(DE-B1597)555432(DE-B1597)9780823263363(Au-PeEL)EBL3239930(CaPaEBR)ebr10930205(CaONFJC)MIL671343(OCoLC)1058263334(MiAaPQ)EBC1884036(Au-PeEL)EBL1884036(MiAaPQ)EBC30251562(Au-PeEL)EBL30251562(EXLCZ)99267000000058225720140917h20152015 uy 0engur|||||||||||txtccrWhat's these worlds coming to? /Jean-Luc Nancy and Aurelien Barrau ; translated by Travis Holloway and Flor MechainFirst edition.New York :Fordham University Press,2015.©20151 online resource (129 p.)Forms of LivingBibliographic Level Mode of Issuance: Monograph0-8232-6333-9 1-322-40061-X Includes bibliographical references.Front matter --Contents --Foreword. To Inhabit a World --Translators’ Preface --Preamble --More than One --Less Than One, Then --Of Struction --. . . And of Unistruction --NotesOur contemporary challenge, according to Jean-Luc Nancy and Aurelien Barrau, is that a new world has stolen up on us. We no longer live in a world, but in worlds. We do not live in a universe anymore, but rather in a multiverse. We no longer create; we appropriate and montage. And we no longer build sovereign, hierarchical political institutions; we form local assemblies and networks of cross-national assemblages— and we do this at the same time as we form multinational corporations that no longer pay taxes to the state. In such a time, one of the world’s most eminent philosophers and an emerging astrophysicist return to the ancient art of cosmology. Nancy and Barrau’s work is a study of life, plural worlds, and what the authors call the struction or rebuilding of these worlds. Nancy and Barrau invite us on an uncharted walk into barely known worlds when an everyday French idiom, “What’s this world coming to?,” is used to question our conventional thinking about the world. We soon find ourselves living among heaps of odd bits and pieces that are amassing without any unifying force or center, living not only in a time of ruin and fragmentation but in one of rebuilding. Astrophysicist Aurelien Barrau articulates a major shift in the paradigm of contemporary physics from a universe to a multiverse. Meanwhile, Jean-Luc Nancy’s essay “Of Struction” is a contemporary comment on the project of deconstruction and French poststructuralist thought. Together Barrau and Nancy argue that contemporary thought has shifted from deconstruction to what they carefully call the struction of dis-order.Forms of Living (FUP)PhenomenologyHistory20th centuryDeconstruction.Deleuze.Derrida.Khora.Multiverse.Nancy.Timaeus.cosmology.life.world.PhenomenologyHistory142.7Nancy Jean-Luc157114Barrau AurélienHolloway TravisMechain FlorMiAaPQMiAaPQMiAaPQBOOK9910788039103321What's these worlds coming to3814577UNINA