03430nam 22006735 450 99646594290331620200630054402.03-642-40415-410.1007/978-3-642-40415-3(CKB)3710000000015923(SSID)ssj0000988171(PQKBManifestationID)11515420(PQKBTitleCode)TC0000988171(PQKBWorkID)10949872(PQKB)11114714(DE-He213)978-3-642-40415-3(MiAaPQ)EBC3093166(PPN)172429463(EXLCZ)99371000000001592320130816d2013 u| 0engurnn#008mamaatxtccrIntelligent Virtual Agents[electronic resource] 13th International Conference, IVA 2013, Edinburgh, UK, August 29-31, 2013, Proceedings /edited by Ruth Aylett, Brigitte Krenn, Catherine Pelachaud, Hiroshi Shimodaira1st ed. 2013.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2013.1 online resource (XVIII, 493 p. 113 illus.)Lecture Notes in Artificial Intelligence ;8108Bibliographic Level Mode of Issuance: Monograph3-642-40414-6 Cognitive Models -- Applications -- Dialogue, Language, and Speech -- Non-verbal Behaviour -- Social, Cultural Models and Agents -- Tools and Techniques.This book constitutes the proceedings of the 13th International Conference on Intelligent Virtual Agents, IVA 2013, held in Edinburgh, UK, in August 2013. There was a total of 94 submissions. The 18 full and 18 short papers presented in this volume were carefully reviewed and selected for inclusion in the book. In addition, the volume lists the 34 posters which were on display during the conference. The papers are organized in topical sections named: cognitive models; applications; dialogue, language, speech; non-verbal behaviour; and social, cultural models and agents.Lecture Notes in Artificial Intelligence ;8108Artificial intelligenceUser interfaces (Computer systems)Computer simulationArtificial Intelligencehttps://scigraph.springernature.com/ontologies/product-market-codes/I21000User Interfaces and Human Computer Interactionhttps://scigraph.springernature.com/ontologies/product-market-codes/I18067Simulation and Modelinghttps://scigraph.springernature.com/ontologies/product-market-codes/I19000Artificial intelligence.User interfaces (Computer systems).Computer simulation.Artificial Intelligence.User Interfaces and Human Computer Interaction.Simulation and Modeling.003.3Aylett Ruthedthttp://id.loc.gov/vocabulary/relators/edtKrenn Brigitteedthttp://id.loc.gov/vocabulary/relators/edtPelachaud Catherineedthttp://id.loc.gov/vocabulary/relators/edtShimodaira Hiroshiedthttp://id.loc.gov/vocabulary/relators/edtMiAaPQMiAaPQMiAaPQBOOK996465942903316Intelligent Virtual Agents772267UNISA06683nam 2201957z- 450 991058593890332120220812(CKB)5600000000483093(oapen)https://directory.doabooks.org/handle/20.500.12854/91173(oapen)doab91173(EXLCZ)99560000000048309320202208d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNovel Strategies in the Development of New Therapies, Drug Substances and Drug CarriersBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (450 p.)3-0365-4646-4 3-0365-4645-6 This book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug-protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches.ChemistrybicsscResearch & information: generalbicssc1,2,4-triazole25 vitamin D 24-hydroxylaseA-ringactive substance delivery systemsactive substance-controlled releaseADMEalkaloidsalpha-ketoglutarateanalogue actions at genesanti-depressant therapyanti-inflammatory activityanticancer activityanticancer druganticancer drugsantidepressantsantimalarialantimicrobial activityantimicrobial compoundsantimicrobial peptide (AMP)antioxidant activityantiparasitic agentsantiviral proteinsapoptosisAu(III) complexbiomarkerbiomedical hydrogelscalcilyticcalcimimeticcalcium-sensing receptorcancercancer cellscancer therapycancer treatmentCD-ringcell cyclecell invasioncell migrationChelidonium majusChIP-chip analysiscolon cancercolorectal cancercopper (II) complexesCRISPR/Cas9cyclooxygenaseCYP24A1CYP24A1-dependent metabolismCYP27B1cytotoxic activitycytotoxic studycytotoxicitydefense-related proteinsdepressiondermaseptindistal enhancersdrugdrug designdrug design and discoverydrug discoverydual 5-HT1A/SERT activityelectrochemistryenantiomerfluorinefrog skin peptidesgenisteingenome editingglucose metabolismglycoconjugatesgoldgold electrodegreater celandinehemolysishigh-grade serous ovarian cancer cellshistone deacetylase (HDAC)histone H3 acetylationHT-29human DNA topoisomerasehydrogels for cosmetologyhydrogels for dermatologyIL-8inflammationJNKlatexLHRHlung cancermajor latex proteinMALDImetabolitemetallodrugsmethotrexatemolecular dockingmolecular modelingmultimodal activityn/ananoparticlesorganometallicoxidation mechanismsPhyllomedusa bicolorPlasmodium falciparum (P. falciparum)PRI-2191proliferationprostate cancerproteome analysispyridazinonepyrido[1,2-c]pyrimidinesresveratrolricketsRNA polymerase IISARself-assembled monolayerside-chainspectroscopic datasplit luciferase-based biosensorstereospecificitysynthesistargeted therapytetrahydro-β-carbolinesTGF-βtherapeutic peptidesthioureatranscriptiontransdermal active substance delivery systemsVEGFvitamin Dvitamin D analogsvitamin D biology and actionvitamin D hormone (1,25(OH)2D3)vitamin D receptorvitamin D3Warburg effectChemistryResearch & information: generalKutner Andrzejedt1313410Brown GeoffreyedtKallay EniköedtKutner AndrzejothBrown GeoffreyothKallay EniköothBOOK9910585938903321Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers3031397UNINA