02998oam 2200469 450 99641844550331620210415093533.03-030-60235-410.1007/978-3-030-60235-2(CKB)4100000011508833(DE-He213)978-3-030-60235-2(MiAaPQ)EBC6381106(PPN)252519132(EXLCZ)99410000001150883320210415d2020 uy 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierOptical whispering gallery modes for biosensing from physical principles to applications /Frank Vollmer, Deshui Yu1st ed. 2020.Cham, Switzerland :Springer,[2020]©20201 online resource (XIII, 417 p. 142 illus.) Biological and Medical Physics, Biomedical Engineering,1618-72103-030-60234-6 From the Contents: Introduction: Need for label-free chip-scale clinical diagnostics and nanoparticle analyzers -- Fundamentals of photonics (light, wave, polarization, interference) -- Fundamental optical properties of biomolecules -- Light matter interaction with biomolecules (Lorentz- model, drude-model, light at a sensor interface, reflection, transmission, evanescent field) -- Physics of optical micro-resonators (fabry perot, microsphere, resonance, photonic atom model, photonic crystals, ring resonator, bottleneck resonator, microtube resonator, capillary resonator).This interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light–matter interaction, and biomolecular structure with a focus on applications in biosensing. Novel biosensors based on the hybridization of WGM microcavities and localized surface plasmon resonances (LSPRs) in metal nanoparticles have emerged as the most sensitive microsystem biodetection technology that boasts single molecule detection capability without the need for amplification and labeling of the analyte. The book provides an ample survey of the physical mechanisms of WGMs and LSPRs for detecting affinity, concentration, size, shape and orientation of biomarkers, while informing the reader about different classes of biomolecules, their optical properties and their importance in label-free clinical diagnostics. For the more advanced reader, advanced applications of WGMs and LSPRs in exploring the fundamental nature of quantum physics are discussed. .Biological and Medical Physics, Biomedical Engineering,1618-7210BiosensorsBiosensors.610.28Vollmer Frank843496Yu DeshuiMiAaPQMiAaPQUtOrBLWBOOK996418445503316Optical whispering gallery modes for biosensing2255290UNISA