01595nam 2200373 n 450 99639761930331620200818212954.0(CKB)4940000000064865(EEBO)2248498964(UnM)99827892e(UnM)99827892(EXLCZ)99494000000006486519950316d1687 uy |engurbn||||a|bb|The galant seamans return from the Indies, or the happy meeting of two faithful lovers[electronic resource] Wherein is shewed the loyal constancy of a seaman to his love, with her kind salutation unto him for his welcome home. Observe this song which is both neat and pretty Tis on a seaman in his praise of Betty. Tune of Five sail of frigots, or Shrewsbury By T.L. With allowance[London] Printed for W. Thackery, and T. Passenger[1687?]1 sheet ([1] p.) ill. (woodcuts)T.L. = Thomas Lanfiere.Place of publication from Wing; suggested publication date in Wing = [1686-88].Verse - "I am a stout Seaman newly come on shore".Reproduction of the original in the Bodleian Library.eebo-0014Ballads, English17th centuryBallads, EnglishLanfiere Thomas1001731Cu-RivESCu-RivESCStRLINWaOLNBOOK996397619303316The galant seamans return from the Indies, or the happy meeting of two faithful lovers2367267UNISA05294nam 2200685 450 991078742560332120230120002213.00-12-801361-3(CKB)3710000000346456(EBL)1934473(SSID)ssj0001430290(PQKBManifestationID)11820981(PQKBTitleCode)TC0001430290(PQKBWorkID)11469740(PQKB)11245352(MiAaPQ)EBC1934473(Au-PeEL)EBL1934473(CaPaEBR)ebr11014738(CaONFJC)MIL732176(OCoLC)902956991(EXLCZ)99371000000034645620150212h20152015 uy 0engur|n|---|||||txtccrAdvances in cancer researchVolume 125ABC transporters and cancer /edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others]First edition.London, England :Academic Press,2015.©20151 online resource (280 p.)Description based upon print version of record.1-336-00894-6 0-12-801251-X Includes bibliographical references at the end of each chapters and index.Front Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s...3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; ReferencesChapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th...; 5.1. P-glycoprotein5.2. BCRP<i> ABC Transporters and Cancer</i> provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike. <br><br><ul><li>Provides information on cancer research</li><li>Outstanding and original reviews</li><li>Suitable for researchers and students</li></ul>CancerResearchDrug resistance in cancer cellsCancerChemotherapyCancerResearch.Drug resistance in cancer cells.CancerChemotherapy.616.9940072Schuetz John D.Ishikawa ToshihisaAmbudkar Suresh V.MiAaPQMiAaPQMiAaPQBOOK9910787425603321Advances in cancer research802501UNINA01244nam 2200397 450 991082368980332120230814223947.080-246-3761-8(CKB)4100000005878249(MiAaPQ)EBC5488846(Au-PeEL)EBL5488846(CaPaEBR)ebr11599809(OCoLC)1048003819(EXLCZ)99410000000587824920180913d2018 uy 0czeurcnu||||||||txtrdacontentcrdamediacrrdacarrierDiagnostika a lćba osteoporózy a dalsích onemocnení skeletu /Valér Dzupa, Jirí Jensovský (editors)[Place of publication not identified] :Karolinum,2018.1 online resource (230 pages) illustrations80-246-3741-3 OsteoporosisTreatmentOsteoporosisTreatment.616.716Dzupa ValérJenšovský JiříMiAaPQMiAaPQMiAaPQBOOK9910823689803321Diagnostika a lćba osteoporózy a dalsích onemocnení skeletu3918969UNINA