05349nam 22006614a 450 991045823820332120200520144314.01-281-07062-997866110706250-12-289632-70-08-054118-6(CKB)1000000000384343(EBL)319073(OCoLC)476114626(SSID)ssj0000245831(PQKBManifestationID)11234644(PQKBTitleCode)TC0000245831(PQKBWorkID)10179785(PQKB)10456664(MiAaPQ)EBC319073(PPN)182573206(Au-PeEL)EBL319073(CaPaEBR)ebr10206109(CaONFJC)MIL107062(EXLCZ)99100000000038434320011010d2002 uy 0engur|n|---|||||txtccrSignal transduction[electronic resource] /Bastien D. Gomperts, Peter E.R. Tatham, IJsbrand M. KramerSan Diego, Calif. Academic Pressc20021 online resource (441 p.)Description based upon print version of record.0-12-289631-9 Includes bibliographical references and index.Front Cover; Signal Transduction; Copyright Page; Contents; Preface; Chapter 1. Prologue: Signal transduction, origins and personalities; Transduction, the word and its meaning: one dictionary, different points of view; Hormones, evolution and history; Hormones: a definition; Neurotransmitters; Ergot; Receptors and ligands; Chapter 2. First messengers; Hormones; Binding of ligands to receptors; Chapter 3. Receptors; Adrenaline (again); a- and ß-adrenergic receptors; Acetylcholine receptors; Ion channel-linked receptors; The 7TM superfamily of G-protein linked receptorsReceptor-ligand interaction and receptor activationTransmitting signals into cells; Intracellular 7TM receptor domains and signal transmission; Adrenaline (yet again); Chapter 4. GTP-binding proteins and signal transduction; Nucleotides as metabolic regulators; GTP-binding proteins, G-proteins or GTPases; Ras proteins; Ras-GAPs; Essay: Activation of G-proteins without subunit dissociation; Chapter 5. Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C; Adenylyl cyclase; Phospholipase C; Chapter 6. The regulation of visual transductionSensitivity of photoreceptorsPhotoreceptor mechanisms; Adaptation: calcium acts as a negative regulator; Photo-excitation of rhodopsin; Switching off the mechanism; A note on phototransduction in invertebrates; Chapter 7. Calcium and signal transduction; A new second messenger is discovered; Calcium and evolution; Distinguishing Ca2+ and Mg2+; Free, bound and trapped Ca2+; Cytosol Ca2+ is kept low; Detecting changes in cytosol Ca2+; Mechanisms that elevate cytosol Ca2+ concentration; The pattern of cytosol Ca2+ changes in single cells; Localization of intracellular second messengersChapter 8. Calcium signallingCalcium binding by proteins; Effects of elevated calcium; Paradigms of calcium signalling; Chapter 9. Phosphorylation and dephosphorylation: Protein kinases A and C; Protein phosphorylation as a switch in cellular functioning; cAMP and the amplification of signals; Protein kinase A; Protein kinase A and the regulation of transcription; Protein kinase A and the activation of ERK; Actions of cAMP not mediated by PKA; Protein kinase C; The protein kinase C family; Structural domains and activation of protein kinase CMultiple sources of DAG and other lipids to activate PKCDifferential localization of PKC isoforms; PKC anchoring proteins, STICKs, PICKs and RACKs; PKC and cell transformation; PKC and inflammation; Chapter 10. Growth factors: Setting the framework; Viruses and tumours; The discovery of NGF... and EGF; Platelet derived growth factor; Transforming growth factors; Problems with nomenclature; Essay: The cell cycle; Essay: Cancer and cell transformation; Chapter 11. Signalling pathways operated by receptor protein tyrosine kinases; The tyrosine kinase family; Tyrosine kinase-containing receptorsBranching of the signalling pathwaySignal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scienCellular signal transductionElectronic books.Cellular signal transduction.571.6Gomperts B. D1056431Tatham Peter E. R723856Kramer Ijsbrand M512673MiAaPQMiAaPQMiAaPQBOOK9910458238203321Signal transduction2490786UNINA01412nam 2200301Ia 450 99639720290331620210104171941.0(CKB)4940000000063326(EEBO)2248531701(OCoLC)ocn688636103e(OCoLC)688636103(EXLCZ)99494000000006332620101202d1642 uy 0engurbn||||a|bb|The answer of both Houses of Parliament presented to His Majestie at York the ninth of May, 1642[electronic resource] To two messages sent to them from His Majestie concerning Sir Iohn Hothams refusall to give His Majestie entrance into his town of Hull. With His Majesties reply thereunto. Published by His Majesties commandLondon Printed by Robert Barker, printer to the Kings most excellent Majestie and by the assignes of John Bill1642[2], 5 pReproduction of original in: Henry E. Huntington Library and Art Gallery.eebo-0113Great BritainHistoryCivil War, 1642-1649Early works to 1800SourcesEarly works to 1800England and Wales.Sovereign (1625-1649 : Charles I)UMIUMIBOOK996397202903316The answer of both Houses of Parliament, presented to His Majestie at York the ninth of May, 16422324162UNISA