04649nam 2200625Ia 450 991045536150332120200520144314.01-60876-247-5(CKB)1000000000787316(EBL)3018369(SSID)ssj0000207494(PQKBManifestationID)12012016(PQKBTitleCode)TC0000207494(PQKBWorkID)10239229(PQKB)10433743(MiAaPQ)EBC3018369(Au-PeEL)EBL3018369(CaPaEBR)ebr10660230(OCoLC)433650297(EXLCZ)99100000000078731620080411d2008 uy 0engur|n|---|||||txtccrMyelin basic protein[electronic resource] /Joan M. Boggs, editorNew York Nova Science Publishersc20081 online resource (261 p.)Intrinsically disordered proteins"Nova biomedical"--Cover.1-60456-699-X Includes bibliographical references and index.""MYELIN BASIC PROTEIN""; ""NOTICE TO THE READER""; ""CONTENTS""; ""PREFACE""; ""REFERENCES""; ""THE PROPERTIES AND FUNCTIONS OF THE GOLLI MYELIN BASIC PROTEINS""; ""ABSTRACT""; ""INTRODUCTION""; ""The MBP gene encodes the “classicâ€? and golli family of proteins""; ""Features of the primary and higher ordered structure of the golli-MBPs""; ""Approaches to defining the biological roles of golli proteins in cells""; ""Unique phenotypes of the golli KO and golli overexpressing mice""; ""Emerging relevance of golli expression in pathology and disease""; ""CONCLUSION""; ""ACKNOWLEDGEMENTS""""REFERENCES""""POSTTRANSLATIONAL MODIFICATIONS OF MYELIN BASIC PROTEINS""; ""ABSTRACT""; ""INTRODUCTION""; ""ACETYLATION""; ""METHYLATION""; ""PHOSPHORYLATION""; ""Deamidation of glutamine at residues 103 and 147""; ""Deimination of arginine residues (citrullination)""; ""CONCLUSION""; ""REFERENCES""; ""DEIMINATION OF MYELIN BASIC PROTEIN BY PAD ENZYMES, AND THEIR ROLE IN MULTIPLE SCLEROSIS""; ""ABSTRACT""; ""INTRODUCTION""; ""MBP CHARGE ISOMERS""; ""CONSEQUENCES OF INCREASED CITRULLINATION OF MBP""; ""A. Proteolysis""; ""B. MBP autocatalysis and neoepitopes""""THE ROLE OF MYELIN BASIC PROTEIN IN MYELIN COMPACTION""""BILAYER STRUCTURE IN NORMAL APPEARING WHITE MATTER (NAWM) IN MS BRAIN IS NOT “NORMALâ€?""; ""MBP MICROHETEROGENEITY IN MS WHITE MATTER""; ""PEPTIDYL ARGININE DEIMINASES (PADS)""; ""THE PAD2 CPG ISLAND""; ""FUTURE DIRECTIONS AND CONCLUDING REMARKS""; ""ACKNOWLEDGEMENTS""; ""REFERENCES""; ""MYELIN BASIC PROTEIN-MEDIATED IMMUNOPATHOGENESIS IN MULTIPLE SCLEROSIS AND EAE""; ""ABSTRACT""; ""INTRODUCTION""; ""EXPRESSION OF MBP IN THE CNS AND THE IMMUNE SYSTEM""; ""MULTIPLE SCLEROSIS AND EAE""""MBP PEPTIDE SPECIFICITY OF CD4+ T CELLS IN MS""""FREQUENCY AND PHENOTYPES OF CD4+ T CELLS IN MS PATIENTS""; ""MBP PEPTIDE SPECIFICITY OF CD4+ T CELLS IN EAE""; ""EAE AND MS: TH1 VS. TH17?""; ""MBP-SPECIFIC CD4+ TCR TRANSGENIC MICE""; ""HUMANIZED MBP-SPECIFIC CD4+ TCR TRANSGENIC MICE""; ""MBP-SPECIFIC CD8+ T CELLS INVOLVED IN MS""; ""PATHOGENICITY OF MBP-SPECIFIC CD8+ T CELLS IS DEMONSTRATED IN NEW EAE MODELS""; ""B CELLS INVOLVED IN MS AND EAE""; ""IMMUNE TOLERANCE TO SELF-ANTIGENS""; ""CD4+ T CELL IMMUNE TOLERANCE TO MBP""; ""CD8+ T CELL IMMUNE TOLERANCE TO MBP""; ""CONCLUSION""""REFERENCES""""A STRUCTURAL PERSPECTIVE OF PEPTIDES FROM MYELIN BASIC PROTEIN""; ""ABSTRACT""; ""ABBREVIATIONS""; ""INTRODUCTION""; ""CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101, DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN MBP85-99""; ""Peptide interactions with HLA-DR2A""; ""Peptide interactions with Ob.1A.12 TCR""; ""STRUCTURE OF HUMAN MHC CLASS II COMPLEXED WITH A LONGER EPITOPE PEPTIDE (MBP86-105) FROM HUMAN MYELIN BASIC PROTEIN""; ""Interactions with HLA-DR2a / 2b""; ""Interactions with TCR""""Structure of a human TCR complexed with a peptide from human MBP89-101 and a MHC class II molecule""Intrinsically disordered proteins.Myelin basic proteinMyelin sheathElectronic books.Myelin basic protein.Myelin sheath.572/.633Boggs Joan M974265Boggs Joan M974265MiAaPQMiAaPQMiAaPQBOOK9910455361503321Myelin basic protein2217989UNINA02179nam 2200409Ia 450 99639409130331620200824121641.0(CKB)4940000000114621(EEBO)2248573899(UnM)99895624e(UnM)99895624(EXLCZ)99494000000011462119970609d1685 uy |mulurbn||||a|bb|Joh. Amos Commenii Orbis sensualium pictus: hoc est, omnium fundamentalium in mundo rerum, & in vitâ actionum pictura & nomenclatura.=[electronic resource] Joh. Amos Comme[nius's] Visible world. Or, a picture and nomenclature of all the chief things that are in the world; and of mens employments therein. A work newly written by the author in Latine, and High-Dutch (being one of his last essays, and the most suitable to childrens capacities of any that he hath hitherto made) and translated into English, by Charles Hoole, M.A. for the use of young Latine scholarsLondon printed for Charles Mearne, his Majesties bookseller at the Kings Arms at Charing-Cross1685[16], 309, [11] p. ill., portTitle page (A2) and leaf A7 are cancels.Frontis. port. of author signed: T. Cross Sculpsit."Orbis sensualium pictus. A world of things obvious to the senses drawn in pictures." has a divisional title page on leaf B1r.Reproduction of original in the Folger Shakespeare Library.eebo-0055Latin languageReadersEarly works to 1800Natural historyJuvenile literatureEarly works to 1800Latin languageReadersNatural historyJuvenile literatureComenius Johann Amos1592-1670.385136Hoole Charles1610-1667.793350Cross Thomasfl. 1632-1682,Cu-RivESCu-RivESWaOLNBOOK996394091303316Joh. Amos Commenii Orbis sensualium pictus: hoc est, Omnium fundamentalium in mundo rerum, & in vita actionum, pictura & nomenclatura.2318567UNISA