01149nam--2200373---450-99000312028020331620080620104219.088-6067-003-9000312028USA01000312028(ALEPH)000312028USA0100031202820080620d2005----km-y0itay50------baitaIT||||||||001yyDiario della confraternita preraffaellitaWilliam Michael Rossettiintroduzione, traduzione e note di Manuela D'AmoreLuganoLumières internationalescopyr. 2005XI, 246 p.24 cmOttocento e dintorni22001Ottocento e dintorni2001PreraffaellitiBNCF759.2ROSSETTI,William Michael197868D'AMORE,ManuelaITsalbcISBD990003120280203316XIII.5. 255204378 L.M.XIII.5.00174541BKUMAALESSANDRA9020080620USA011042Diario della confraternita preraffaellita1020093UNISA01409nam 2200361Ia 450 99639340950331620221107224421.0(CKB)3360000000358446(EEBO)2240880395(OCoLC)226319776(EXLCZ)99336000000035844620080428d1635 uy 0engurbn||||a|bb|[Imprint from: Grandsire graybeard. Or Machiavell displayed][electronic resource]London Printed [by William Stansby] for Richard Higgenbotham, and are to bee sold in the bulwarke neere the Tower at the signe of the Vnicorne1635[1+] pTitle supplied by cataloger.An abridgment, with additions, of: Breton, Nicholas. The uncasing of Machivils instructions to his sonne.Printer's name from STC.Imperfect; t.p. fragment of STC 3704.9 only.Identified as STC 19241 on UMI microfilm.Reproduction of original in the British Library.eebo-0018Breton Nicholas1545?-1626?694589Stansby Williamfl. 1597-16381007543Higgenbotham Richardd. 1636.1019427UMIUMIBOOK996393409503316Imprint from: Grandsire graybeard. Or Machiavell displayed2403309UNISA03710nam 2200445 450 991013722170332120230621135336.09782889192618(ebook)(CKB)3710000000520098(WaSeSS)IndRDA00058642(oapen)https://directory.doabooks.org/handle/20.500.12854/60494(EXLCZ)99371000000052009820160629d2014 uy 0engur||#||||||||txtrdacontentcrdamediacrrdacarrierTau oligomers /topic editors, Naruhiko Sahara and Jesus AvilaFrontiers Media SA2014[Lausanne, Switzerland] :Frontiers Media SA,2014.1 online resource (113 pages) illustrations; digital, PDF file(s)Frontiers Research TopicsIncludes bibliographical references.Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.OligomersTau phosphorylationneurodegenerative diseasepropagationTauopathytau proteinOligomers.Jesus Avilaauth1366689Sahara NaruhikoAvila JesusWaSeSSUkMaJRU9910137221703321Tau oligomers3389291UNINA