05615nam 22006974a 450 991014463990332120170810193928.01-280-27548-097866102754890-470-24684-70-471-70910-70-471-70915-8(CKB)1000000000226366(EBL)228461(OCoLC)123239768(SSID)ssj0000229687(PQKBManifestationID)11185821(PQKBTitleCode)TC0000229687(PQKBWorkID)10172433(PQKB)11760606(MiAaPQ)EBC228461(EXLCZ)99100000000022636620040603d2005 uy 0engur|n|---|||||txtccrProteomics today[electronic resource] protein assessment and biomarkers using mass spectrometry, 2D electrophoresis, and microarray technology /Mahmoud Hamdan, Pier Giorgio RighettiHoboken, N.J. John Wiley & Sons20051 online resource (446 p.)Wiley-Interscience series in mass spectrometryDescription based upon print version of record.0-471-64817-5 Includes bibliographical references and index.PROTEOMICS TODAY; CONTENTS; PREFACE TO PART I; ACKNOWLEDGMENT; I INTRODUCTION TO PART I; 1 INSTRUMENTATION AND DEVELOPMENTS; 1.1 Introduction; 1.2 Ionization Techniques for Macromolecules; 1.2.1 (252)Cf Plasma Desorption Ionization; 1.2.2 Fast Atom/Ion Bombardment; 1.2.3 Type of Fragment Ions and Nomenclature; 1.3 Examples on Analytical Solutions Based on FAB-MS; 1.3.1 Detection of Abnormalities in Hemoglobin; 1.3.2 Glycoprotein Structure Determination; 1.3.3 Early Scanning Functions on Sector Machines; 1.4 Electrospray Ionization; 1.5 Matrix-Assisted Laser Desorption Ionization1.5.1 MALDI at High Pressure1.5.2 Desorption Ionization on Silicon (DIOS); 1.5.3 Delayed Extraction; 1.6 Ion Detection; 1.6.1 Microchannel Plates (MCPs); 1.6.2 Cryogenic Detectors; 1.6.2.1 Superconducting Tunnel Junction; 1.6.2.2 Thermal Detectors; 1.7 Types of Analyzers; 1.7.1 Quadrupole Mass Filter; 1.7.2 Three-Dimensional Quadrupole Ion Trap; 1.7.3 Linear Ion Trap; 1.7.4 Time of Flight; 1.7.5 Fourier Transform Ion Cyclotron Resonance; 1.8 Hybrid Analyzers; 1.8.1 Quadrupole Time of Flight; 1.8.2 Ion Mobility-TOF; 1.8.3 Linear Ion Trap-FT-ICR; 1.8.4 Ion Trap-TOF; 1.9 Tandem Mass Spectrometry1.9.1 Postsource Decay1.9.2 MS-MS Measurements; 1.9.3 Collisional Activation; 1.10 Current MS Instrumentation in Proteome Analyses; 1.10.1 MALDI-TOF; 1.10.2 MALDI-TOF-TOF; 1.10.3 FT-ICR-MS; 1.10.4 ION Mobility-MS; 1.11 Current MS-Based Proteomics; 1.11.1 Delivering Peptides to Ion Source; 1.11.2 Peptide Sequencing and Database Searching; 1.11.3 Peptide Mass Fingerprinting; 1.11.4 Searching with MS-MS Data; 1.11.5 Databases for MS Data Search; 1.12 Recent Achievements and Future Challenges; 1.12.1 Current Applications; 1.12.2 Signal Transduction Pathways; 1.13 Concluding Remarks; References2 PROTEOMICS IN CANCER RESEARCH2.1 Introduction; 2.1.1 Two-Dimensional Gel Electrophoresis; 2.1.2 Surface-Enhanced Laser Desorption Ionization; 2.1.3 Protein Microarrays; 2.1.4 Getting More Than Just Simple Change in Protein Expression; 2.1.5 Laser Capture Microdissection; 2.2 Pancreatic Ductal Adenocarcinoma; 2.2.1 Analyses Based on Chip Technology; 2.2.2 SELDI Analysis of Pancreatic Ductal Adenocarcinoma; 2.2.3 Protein Profiling Following Treatment with DNA Methylation/Histone Deacetylation Inhibitors; 2.2.4 Proteomic Profiling of PDAC Following Treatment with Trichostatin A2.2.5 Proteomic Profiling of PDAC Following Treatment with 5 ́-aza-2 ́-deoxycytidine2.3 Proteomic Analysis of Human Breast Carcinoma; 2.3.1 Two-DE Analysis in Breast Cancer; 2.3.2 Proteomic Profiling of Breast Cancer Cell Membranes; 2.3.3 Proteomic Analysis on Selected Tissue Samples; 2.4 Proteomic Profiling of Chemoresistant Cancer Cells; 2.4.1 Protein Alterations in Pancreas Carcinoma Cells Exposed to Anticancer Drug; 2.4.2 Proteomic Profiling of Cervix Squamous Cell Carcinoma Treated with Cisplatin; 2.5 Signal Pathway Profiling of Prostate Cancer2.6 Emerging Role of Functional and Activity-Based Proteomics in Disease UnderstandingThe last few years have seen an unprecedented drive toward the application of proteomics to resolving challenging biomedical and biochemical tasks. Separation techniques combined with modern mass spectrometry are playing a central role in this drive. This book discusses the increasingly important role of mass spectrometry in proteomic research, and emphasizes recent advances in the existing technology and describes the advantages and pitfalls as well.* Provides a scientifically valid method for analyzing the approximatey 500,000 proteins that are encoded in the human genome* Explains tWiley-Interscience series on mass spectrometry.ProteinsSpectraMass spectrometryProteomicsElectronic books.ProteinsSpectra.Mass spectrometry.Proteomics.572.6572.636Hamdan Mahmoud1947-862232Righetti P. G862233MiAaPQMiAaPQMiAaPQBOOK9910144639903321Proteomics today1924673UNINA01401nam 2200349Ia 450 99638602900331620221108063632.0(CKB)1000000000607431(EEBO)2240867724(OCoLC)53981630(EXLCZ)99100000000060743120040106d1698 uy 0engurbn||||a|bb|Act of the Synod of Lothian and Tweeddale, anent the observation of a fast[electronic resource] with the causes thereof. Edinburgh the sixth day of May 1698 years post meridiemEdinburgh Printed by the heirs and successors of Andrew Anderson, printer to the Kings most excellent Majesty16981 sheet ([1] p.)Caption title.Signed at end: Extracted by Jo. Sandilands Cls. Syn. Pr.Reproduction of the original in the National Library of Scotland.eebo-0097Fasts and feastsChurch of ScotlandEarly works to 1800Public worshipScotlandEarly works to 1800BroadsidesScotland17th century.rbgenrFasts and feastsChurch of ScotlandPublic worshipEAEEAEBOOK996386029003316Act of the Synod of Lothian and Tweeddale, anent the observation of a fast2399143UNISA00849nem 2200325 n 450 991079151920332120200520144314.0(CKB)2560000000056944(MiAaPQ)EBC3329479(Au-PeEL)EBL3329479(CaPaEBR)ebr10002319(OCoLC)842620043(EXLCZ)99256000000005694420101210d1999 uy engurcn|||||||||Algeria[electronic resource][S.l.] Maps.comc19991 online resource (1 map)Hypsometric map, Africa, AlgeriaAlgeriaMapsAlgeriaMaps.com (Firm)MiAaPQMiAaPQMiAaPQBOOK9910791519203321Algeria801953UNINA01656nam 2200505 450 991081485510332120230803213639.01-4674-4028-0(CKB)3710000000470755(SSID)ssj0001543950(PQKBManifestationID)16134370(PQKBTitleCode)TC0001543950(PQKBWorkID)12659453(PQKB)11453283(MiAaPQ)EBC4859265(Au-PeEL)EBL4859265(CaPaEBR)ebr11388365(OCoLC)988867295(EXLCZ)99371000000047075520170616h20142014 uy 0engurcnu||||||||txtccrAt the limits of the secular reflections on faith and public life /edited by William A. Barbieri, JrGrand Rapids, Michigan ;Cambridge, England :William B. Eerdmans Publishing Company,2014.©20141 online resource (304 pages)Bibliographic Level Mode of Issuance: Monograph0-8028-6877-0 Includes bibliographical references at the end of each chapters and index.Christianity and politicsCatholic ChurchChristianity and politicsUnited StatesChristianity and politicsCatholic Church.Christianity and politics261Barbieri William A.Jr.,MiAaPQMiAaPQMiAaPQBOOK9910814855103321At the limits of the secular3926315UNINA