01519oam 22004694a 450 991048018630332120210104035558.00-271-08433-20-271-08431-6(CKB)4100000008415474(MiAaPQ)EBC6224515(OCoLC)1103917389(MdBmJHUP)muse84172(EXLCZ)99410000000841547420191021d2019 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierThe Defeat of a Renaissance IntellectualSelected Writings of Francesco Guicciardini /ed. and transl. by Carlo CelliUniversity Park, Pennsylvania :The Pennsylvania State University Press,2019.1 online resource (227 pages) illustrationsEarly modern studies0-271-08348-4 Includes bibliographical references and index.Early modern studies series.1492-1559reroPensee politique et socialereroItaliereroElectronic books. 1492-1559.Pensee politique et sociale.945/.06Guicciardini Francescoaut8569Celli CarloedttrlMdBmJHUPMdBmJHUPBOOK9910480186303321The Defeat of a Renaissance Intellectual2008342UNINA01673oam 2200589zu 450 99620640360331620210807004036.00-470-77832-60-470-77127-50-470-77141-0(CKB)2500000000001595(SSID)ssj0000354603(PQKBManifestationID)11275373(PQKBTitleCode)TC0000354603(PQKBWorkID)10313578(PQKB)10609024(EXLCZ)99250000000000159520160829d1972 uy engtxtccrThe chemistry of acyl halides[Place of publication not identified]Interscience1972The Chemistry of functional groups The chemistry of acyl halidesBibliographic Level Mode of Issuance: Monograph0-471-66936-9 Acyl halidesHalogensAlkaliesInorganic ChemicalsElementsChemicals and DrugsOrganic ChemistryHILCCChemistryHILCCPhysical Sciences & MathematicsHILCCAcyl halidesHalogensAlkaliesInorganic ChemicalsElementsChemicals and DrugsOrganic ChemistryChemistryPhysical Sciences & Mathematics547/.02Patai Saul335987PQKBBOOK996206403603316The chemistry of acyl halides1959130UNISA05421nam 22007334a 450 991014455710332120200520144314.0978661085407397812808540711280854073978352760702035276070219783527606986352760698X(CKB)1000000000377169(EBL)481850(SSID)ssj0000104173(PQKBManifestationID)11122683(PQKBTitleCode)TC0000104173(PQKBWorkID)10079634(PQKB)11073057(MiAaPQ)EBC481850(OCoLC)85820785(Perlego)2750740(EXLCZ)99100000000037716920080226d2005 uy 0engur|n|---|||||txtccrAntigen presenting cells from mechanisms to drug development /edited by Harald Kropshofer and Anne B. VogtWeinheim Wiley-VCHc20051 online resource (653 p.)Description based upon print version of record.9783527311088 3527311084 Includes bibliographical references and index.Antigen Presenting Cells; Contents; Preface; Acknowledgments; List of Contributors; List of Abbreviations; Color Plates; Part I Antigen Presentation in the Immune System; 1 Some Old and Some New Findings on Antigen Processing and Presentation; 1.1 Introduction; 1.2 HEL Processing; 1.3 Selection of Peptide Segments of HEL; 1.4 HEL: Conformational Isomers; 1.4.1 Biology of Type B T Cells; 1.5 Negative Selection and Peripheral Activation to HEL Peptides; 1.6 Response to HEL Immunization in the Draining Lymph Node; Part II Molecular Mechanisms of Antigen Processing2 Antigen Entry Routes - Where Foreign Invaders Meet Antigen Presenting Cells2.1 Introduction; 2.2 Antigen Entry via the Gastrointestinal Tract; 2.2.1 Peyer's Patches; 2.2.2 Mesenteric Lymph Node; 2.2.3 Dendritic Cells of the Lamina Propria; 2.2.4 Pathogens Target Intestinal Antigen Presenting Cells; 2.3 Antigen Entry via the Skin; 2.4 Systemic Dissemination of Antigens/Infectious Microorganisms; 2.5 Antigen Presenting Cells in the Liver; 2.5.1 Dendritic Cells; 2.5.2 Kupffer Cells; 2.5.3 Liver Sinusoidal Endothelial Cells; 2.6 Conclusion3 Antigen Processing in the Context of MHC Class I Molecules3.1 Tracing the Needle in the Haystack: The Efficiency of Antigen Processing and Presentation by MHC Class I Molecules; 3.2 The "Classical" Route: Loading of MHC Class I Molecules With Peptides Generated in the Cytoplasm; 3.2.1 Cytosolic Peptide Processing by Proteasomes and other Proteases; 3.2.1.1 Structure and Function of the Proteasomal Core and Interferon-induced Subunits; 3.2.1.2 Targeting Proteins for ATP-dependent Degradation by 26S Proteasomes; 3.2.1.3 Cleavage Properties of (Immuno)Proteasomes3.2.1.4 Peptide Processing by Nonproteasomal Cytosolic Peptidases3.3 Crossing the Border - Peptide Translocation into the ER by TAP; 3.3.1 Structure and Function of TAP; 3.3.2 Substrate Specificity of TAP; 3.3.3 TAP-independent Peptide Entry into the ER; 3.4 Fitting in the Best: TAP-associated Peptide Loading Complex Optimizes MHC-I Peptide Binding; 3.4.1 Structure of MHC-I Molecules; 3.4.2 Early Steps in the Maturation of MHC-I Molecules; 3.4.3 Structure and Molecular Interactions of Tapasin; 3.4.4 Optimization of Peptide Loading in the TAP-associated Loading Complex3.5 On the Way Out: MHC-I Antigen Processing along the Secretory Route3.6 Closing the Circle - Cross-presentation of Endocytosed Antigens by MHC-I Molecules; 3.6.1 Phagosome-to-cytosol Pathway of MHC-I Peptide Loading; 3.6.2 Endolysosomal Pathway of MHC-I Peptide Loading; 4 Antigen Processing for MHC Class II; 4.1 Introduction; 4.2 Types of Antigen Presenting Cells; 4.2.1 Macrophages, B Lymphocytes and DCs; 4.2.2 Tissue-resident APCs; 4.2.3 Maturation State of APCs; 4.2.3.1 Immature APCs; 4.2.3.2 Mature APCs; 4.3 Antigen Uptake by APCs; 4.3.1 Macropinocytosis; 4.3.2 Phagocytosis4.3.3 Receptors for EndocytosisThis novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system.Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providiAntigen presenting cellsAntigenengttCelbiologiegttFarmacologiegttAntigen presenting cells.Antigenen.Celbiologie.Farmacologie.571.9/67742.15bclKropshofer Harald935713Vogt Anne B935714MiAaPQMiAaPQMiAaPQBOOK9910144557103321Antigen presenting cells2107750UNINA