05756nam 22007214a 450 99620551260331620230617005459.01-280-74787-097866107478700-470-98845-21-4051-7319-X(CKB)1000000000341982(EBL)284301(OCoLC)437176174(SSID)ssj0000228135(PQKBManifestationID)12029325(PQKBTitleCode)TC0000228135(PQKBWorkID)10148758(PQKB)11629985(MiAaPQ)EBC284301(EXLCZ)99100000000034198220041217d2005 uy 0engur|n|---|||||txtccrProcess analytical technology[electronic resource] spectroscopic tools and implementation strategies for the chemical and pharmaceutical industries /edited by Katherine A. BakeevOxford, UK ;Ames, Iowa Blackwell Pub.20051 online resource (476 p.)Description based upon print version of record.1-4051-2103-3 Includes bibliographical references and index.Process Analytical Technology : Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries; Contents; Contributors; Preface; List of Abbreviations; 1 Process Analytical Chemistry: Introduction and Historical Perspective; 1.1 Historical perspective; 1.2 Early instrument development; 1.3 Sampling systems; 1.4 Examples; References; 2 Implementation of Process Analytical Technologies; 2.1 Introduction to implementation of process analytical technologies (PATs) in the industrial setting; 2.1.1 Definition of process analytics2.1.2 Differences between process analyzers and laboratory analysis2.1.3 General industrial drivers for process analytics; 2.1.4 Types of applications (R&D vs. Manufacturing); 2.1.5 Organizational considerations; 2.2 Generalized process analytics work process; 2.2.1 Project identification and definition; 2.2.2 Analytical application development; 2.2.3 Design, specify and procure; 2.2.4 Implementation in production; 2.2.5 Routine operation; 2.2.6 Continuous improvement; 2.3 Differences between implementation in chemical and pharmaceutical industries; 2.3.1 Introduction; 2.3.2 Business model2.3.3 Technical differences2.3.4 Regulatory differences; 2.4 Conclusions; References; 3 Near-Infrared Spectroscopy for Process Analytical Chemistry: Theory, Technology and Implementation; 3.1 Introduction; 3.2 Theory of near-infrared spectroscopy; 3.2.1 Molecular vibrations; 3.2.2 Anharmonicity of the potential well; 3.2.3 Combination and overtone absorptions in the near-infrared; 3.2.4 Examples of useful near-infrared absorption bands; 3.3 Analyser technologies in the near-infrared; 3.3.1 The scanning grating monochromator; 3.3.2 Light sources and detectors for near-infrared analysers3.3.3 The polychromator photodiode-array analyser3.3.4 The acousto-optic tunable (AOTF) analyser; 3.3.5 Fourier transform near-infrared analysers; 3.4 The sampling interface; 3.4.1 Introduction; 3.4.2 Further discussion of sampling issues; 3.4.3 The use of fibre-optics; 3.5 Conclusion; Bibliography; 4 Infrared Spectroscopy for Process Analytical Applications; Abstract; 4.1 Introduction; 4.2 Basic IR spectroscopy; 4.3 Instrumentation design and technology; 4.4 Process IR instrumentation; 4.4.1 Commercially available IR instruments; 4.4.2 Important IR component technologies4.4.3 New technologies for IR components and instruments4.4.4 Requirements for process infrared analyzers; 4.4.5 Sample handling for IR process analyzers; 4.4.6 Issues for consideration in the implementation of process IR; 4.5 Applications of process IR analyzers; 4.6 Process IR analyzers: A review; 4.7 Trends and directions; References; 5 Process Raman Spectroscopy; 5.1 How Raman spectroscopy works; 5.2 When Raman spectroscopy works well and when it does not; 5.2.1 Advantages; 5.2.2 Disadvantages and risks; 5.3 What are the special design issues for process Raman instruments?; 5.3.1 Safety5.3.2 Laser wavelength selectionThe use of real or near real time measurement of chemical production process parameters as the basis for achieving control or optimisation of a manufacturing process has wide application in the petrochemical, food and chemical industries. Process analytical chemistry (PAC), or process analytical technology (PAT) as it has recently been called, is now being deployed in the pharmaceutical industry, where it is seen as a technology that can help companies to improve their conformity with manufacturing compliance regulations. The objective of this book is to provide a starting point Chemical process controlIndustrial applicationsChemistry, TechnicalChemistry, AnalyticTechnological innovationsChemistry, AnalyticTechniqueSpectrum analysisPharmaceutical chemistryChemical process controlIndustrial applications.Chemistry, Technical.Chemistry, AnalyticTechnological innovations.Chemistry, AnalyticTechnique.Spectrum analysis.Pharmaceutical chemistry.660.2660.29660/.2Bakeev Katherine A942478MiAaPQMiAaPQMiAaPQBOOK996205512603316Process analytical technology2126814UNISA