05064nam 2200589Ia 450 99620397530331620230607221551.01-281-32244-X97866113224410-470-75062-60-470-75167-3(CKB)1000000000406326(EBL)351004(OCoLC)437214010(SSID)ssj0000121987(PQKBManifestationID)11147925(PQKBTitleCode)TC0000121987(PQKBWorkID)10109930(PQKB)10343490(MiAaPQ)EBC351004(EXLCZ)99100000000040632620010403d2001 uy 0engur|n|---|||||txtccrChromatin and gene regulation[electronic resource] mechanisms in epigenetics /Bryan M. TurnerOxford ;Malden, MA Blackwell Science20011 online resource (298 p.)Description based upon print version of record.0-86542-743-7 Includes bibliographical references and index.Chromatin and Gene Regulation; Contents; Preface; Prologue; Chapter 1 Controlling Transcription: Shared Aims and Common Mechanisms; Introduction; Some general principles; Transcription in prokaryotes; Genetic switches in bacteria; Chapter 2 Transcription in Eukaryotes: The Problems of Complexity; Introduction; The emergence of eukaryotes; The transcription machinery in eukaryotes; General transcription factors, TAFs and the PolII pre-initiation complex; Transcription by PolI and PolIII; The elongation stage; Experimental considerations; Large genome problems: why are things so complicated?Chapter 3 The Nucleosome: Chromatin's Structural UnitIntroduction; Exploring how DNA is packaged in the nucleus; The structure of the nucleosome; Chapter 4 Histone Tails: Modifications and Epigenetic Information; Introduction; The histone tails; Histone modifications; Histone variants; Chapter 5 Higher-Order Chromatin Structures and Nuclear Organization; Introduction; The 30 nm fibre; DNA loops; The nuclear matrix and chromosome scaffolds; Scaffold/matrix associated regions (SARs and MARs); Chromosome bands and functional domains; Nuclear domains and structure in the interphase nucleusChapter 6 Transcription in a Chromatin EnvironmentIntroduction; Genes are packaged into nucleosomes, even when they are being transcribed; Genetic experiments in yeast show the importance of histones for gene regulation; Changes in chromatin structure precede gene activation; Increased histone acetylation can precede or accompany the onset of transcription; DNaseI hypersensitive sites; Nucleosome positioning in vitro and in vivo; Chromatin domains; Chapter 7 How the Transcription Machinery Deals with Chromatin; Introduction; In vitro studies of transcription factor bindingA crowded nucleosome: Mouse Mammary Tumour Virus nucleosome BThe opportunities presented by DNA replication; Chromatin and the elongation stage of transcription; Chapter 8 Chromatin Remodelling Machines; Introduction; Nucleosome remodelling enzymes; Histone acetyltransferases (HATs); Histone deacetylases; The nuclear receptors; Chromatin and cancer; Chapter 9 Heterochromatin; Introduction; α and β heterochromatin in Drosophila; Facultative and constitutive heterochromatin; Heterochromatin DNA; Heterochromatin genes; Heterochromatin proteins; Position effect variegationHeterochromatin and gene expression in mammalsChapter 10 Long-term Silencing of Gene Expression; Introduction; DNA methylation; Silencing at telomeres and mating type loci in yeast; Chapter 11 Cellular Memory and Imprinting; Introduction; Maintenance of transcriptional states; Imprinted genes; Chapter 12 Mechanisms of Dosage Compensation; Introduction; Methods of sex determination; Dosage compensation in mammals; Dosage compensation in Drosophila; Dosage compensation in C. elegans; Lessons from dosage compensation; IndexWritten in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes ChromatinGenetic regulationChromatin.Genetic regulation.572.865Turner Bryan M944682MiAaPQMiAaPQMiAaPQBOOK996203975303316Chromatin and gene regulation2132538UNISA04258nam 22006495 450 991030041870332120200702104405.03-319-10283-410.1007/978-3-319-10283-2(CKB)3710000000248992(EBL)1968633(OCoLC)908090086(SSID)ssj0001354153(PQKBManifestationID)11747066(PQKBTitleCode)TC0001354153(PQKBWorkID)11323204(PQKB)10270932(DE-He213)978-3-319-10283-2(MiAaPQ)EBC1968633(PPN)181354551(EXLCZ)99371000000024899220140924d2015 u| 0engur|n|---|||||txtccrHigh-Precision Studies of Compact Variable Stars /by Steven Bloemen1st ed. 2015.Cham :Springer International Publishing :Imprint: Springer,2015.1 online resource (138 p.)Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053"Doctoral thesis accepted by the KU Leuven, Belgium."3-319-10282-6 Includes bibliographical references at the end of each chapters and index.Introduction -- Spin-resolved spectroscopy of the intermediate polar DQ Her -- Spectral variability on the spin period of the white dwarf in V455 And -- Kepler observations of the beaming binary KPD1946+4340 -- Doppler beaming and Rømer delay in the Kepler data of KOI-74 -- A new grid of evolutionary sdB models and their pulsational properties -- MAIA: the Mercator Advanced Imager for Asteroseismology -- Conclusions and future prospects.This book, which is a reworked and updated version of Steven Bloemen’s original PhD thesis, reports on several high-precision studies of compact variable stars. Its strength lies in the large variety of observational, theoretical and instrumentation techniques that are presented and used and paves the way towards new and detailed asteroseismic applications of single and binary subdwarf stars. Close binary stars are studied using high cadence spectroscopic datasets collected with state of the art electron multiplying CCDs and analysed using Doppler tomography visualization techniques. The work touches upon instrumentation, presenting the calibration of a new fast, multi-colour camera installed at the Mercator Telescope on La Palma. The thesis also includes theoretical work on the computation of the temperature range in which stellar oscillations can be driven in subdwarf B-stars. Finally, the highlight of the thesis is the measurement of velocities of stars using only photometric data from NASA's Kepler satellite. Doppler beaming causes stars to appear slightly brighter when they move towards us in their orbits, and this subtle effect can be seen in Kepler's brightness measurements. The thesis presents the first validation of such velocity measurements using independent spectroscopic measurements. Since the detection and validation of this Doppler beaming effect, it has been used in tens of studies to detect and characterize binary star systems, which are key calibrators in stellar astronomy.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053AstrophysicsAstronomyObservationsAstronomy—ObservationsAstrophysics and Astroparticleshttps://scigraph.springernature.com/ontologies/product-market-codes/P22022Astronomy, Observations and Techniqueshttps://scigraph.springernature.com/ontologies/product-market-codes/P22014Astrophysics.AstronomyAstronomy—Observations.Astrophysics and Astroparticles.Astronomy, Observations and Techniques.523.8874Bloemen Stevenauthttp://id.loc.gov/vocabulary/relators/aut792299MiAaPQMiAaPQMiAaPQBOOK9910300418703321High-Precision Studies of Compact Variable Stars1771587UNINA