05099nam 2200601 450 99620213870331620170810191502.01-281-84264-897866118426423-527-61491-53-527-61490-7(CKB)1000000000376620(EBL)482090(OCoLC)289274500(SSID)ssj0000125256(PQKBManifestationID)11146551(PQKBTitleCode)TC0000125256(PQKBWorkID)10026720(PQKB)11655674(MiAaPQ)EBC482090(PPN)20439161X(EXLCZ)99100000000037662020160819h19961996 uy 0engur|n|---|||||txtccrCombinatorial peptide and nonpeptide libraries a handbook /edited by Günther JungWeinheim, [Germany] :VCH,1996.©19961 online resource (574 p.)Description based upon print version of record.3-527-29380-9 Includes bibliographical references and index.Combinatorial Peptide and Nonpeptide Libraries; Preface; Contents; List of Contributors; List of Abbreviations; 1 Natural Peptide Libraries of Microbial and Mammalian Origin; 1.1 Introduction; 1.2 Natural Peptide Libraries of Microbial Origin; 1.2.1 Microbial Polypeptide Antibiotics by Multienzymatic Thiotemplate Synthesis; 1.2.2 Polypeptide Antibiotics by Ribosomal Precursor Protein Synthesis and Posttranslational Modifications; 1.2.3 Combinatorial Biosynthesis and Biological Diversity of Polyketids; 1.3 Natural Peptide Libraries of Mammalian Origin1.3.1 Self-peptide Libraries Isolated from MHC-Class I Molecules1.3.2 Self-peptide Libraries Isolated from MHC-Class II Molecules; 1.4 From Natural to Synthetic Peptide Libraries; 1.4.1 Synthetic Methods and the Variety of Peptide and Oligomer Libraries; 1.4.2 Analysis of Synthetic Peptide Libraries; 1.4.3 Selected Applications of Synthetic Peptide Libraries; References; 2 Polymer Supported Organic Synthesis: A Review; 2.1 Introduction; 2.2 Solid-Phase Organic Synthesis and Analytics; 2.2.1 Advantages of Solid-Phase Synthesis in Organic Reactions and Product Work-Up2.2.2 Supports and Anchors2.2.3 Multiple, Parallel Syntheses; 2.2.4 Analytics and Monitoring of Solid-Phase Reactions; 2.3 Examples of Solid-Phase Syntheses of Small Molecules; 2.3.1 Immobilization and Reactions with Hydroxy Compounds; 2.3.1.1 Derivatization of Hydroxy Compounds by Mitsunobu Reaction; 2.3.2 Immobilization and Derivatization of Aldehydes and Ketones; 2.3.3 Immobilization and Derivatization of Dicarboxylic Acids and Their Derivatives; 2.3.4 Ring Closure Reactions; 2.3.5 Heterocyclic Compounds: Benzodiazepines, Hydantoins and Thiazolidines2.3.6 Further Ring Closures on Solid Support2.3.7 Palladium Catalyzed C-C Attachments; 2.3.8 Further Reactions on Polymeric Support; 2.4 Oligomer Synthesis; 2.4.1 Peptoids; 2.4.2 Oligocarbamates; 2.4.3 Peptide-Nucleic Acids (PNA); 2.4.4 Oligoureas; 2.5 Outlook; Acknowledgments; References; 3 From Multiple Peptide Synthesis to Peptide Libraries; 3.1 Introduction; 3.2 Simultaneous Multiple Peptide Synthesis (SMPS); 3.2.1 Tea-Bag Synthesis; 3.2.2 Cellulose as Support in Multiple Syntheses; 3.2.3 Polystyrene-Grafted Polyethylene (PS-PE) Film, a New Resin?3.2.4 Automated Multiple Peptide Synthesizers3.2.5 Synthesis of Polymer-Bound Peptides; 3.2.6 Spot Synthesis; 3.2.7 Spatially Addressed Synthesis of Thousands of Peptides; 3.2.8 Microstructured Peptide-Gold Electrode; 3.2.9 Peptide Functionalized Surface by Electrochemical Polymerization; 3.3 Peptide Libraries; 3.3.1 Mixotopes; 3.3.2 Mimotopes; 3.3.3 Phage Libraries and Biopanning; 3.3.4 Random Libraries; 3.3.5 Modified Peptide Libraries; 3.3.6 Identification of the Active Compounds; 3.4 Conclusions; References; 4 Chemical Synthesis of Peptide Libraries; 4.1 The Portioning-Mixing Method4.1.1 Principles and RealizationWith combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research.FasCombinatorial chemistryHandbooks, manuals, etcCombinatorial chemistry547.756Jung GüntherMiAaPQMiAaPQMiAaPQBOOK996202138703316Combinatorial peptide and nonpeptide libraries2002553UNISA