01694nam--2200469---450-99000111233020331620060317093819.088-207-3010-3000111233USA01000111233(ALEPH)000111233USA0100011123320021206d2000----km-y0enga50------baitaITy|||z|||001yyAll'origine del romanzo in Italiail <<celebre Abate Chiari>>Carlo A. MadrignaniNapoliLiguori2000VIII, 354 p.24 cmBibliotecaLetterature422001BibliotecaLetteratureChiari,PietroOpere narrativeGiudizi contemporaneiRomanzoTeorieItaliaSec. 18.853.6MADRIGNANI,Carlo A.157510ITsalbcISBD990001112330203316VI.3.B. 2495(V B Coll.133/42)163943 L.M.V B Coll.00098487VI.3.B. 2495a(V B Coll.133/42 BIS)163942 L.M.V B Coll.00098488VI.3.B. 2495b(V B Coll.133/42 A)163944 L.M.V B00098510V B Coll.133/42 B184320 L.M.V B Coll.00118095V B Coll.133/42 C184321 L.M.V B Coll.00118100V B Coll.133/42 D184322 L.M.V B Coll.00118099BKUMAMARIA1020021206USA011057PAOLA9020030306USA011045PATRY9020040406USA011717PECORARO9020051202USA011314COPAT79020060317USA010938All'origine del romanzo in Italia490622UNISA03571nam 2200601 a 450 991014087300332120210604112026.01-283-14057-897866131405793-527-63318-93-527-63316-23-527-63317-0(CKB)2670000000060524(EBL)645017(OCoLC)714798782(SSID)ssj0000472391(PQKBManifestationID)12168033(PQKBTitleCode)TC0000472391(PQKBWorkID)10434202(PQKB)10620790(MiAaPQ)EBC645017(EXLCZ)99267000000006052420110114d2011 uy 0engur|n|---|||||txtccrProdrugs and targeted delivery[electronic resource] towards better ADME properties /edited by Jarkko RautioWeinheim, Germany Wiley-VCH20111 online resource (522 p.)Methods and principles in medicinal chemistry ;v. 47Description based upon print version of record.3-527-32603-0 Includes bibliographical references and index.Prodrugs and Targeted Delivery: Towards Better ADME Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Prodrug Design and Intellectual Property; 1 Prodrug Strategies in Drug Design; 2 The Molecular Design of Prodrugs by Functional Group; 3 Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites; Part Two: Prodrugs Addressing ADMET Issues; 4 Increasing Lipophilicity for Oral Drug Delivery; 5 Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery6 Prodrugs Designed to Target Transporters for Oral Drug Delivery7 Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement; 8 Ocular Delivery Using Prodrugs; 9 Reducing Presystemic Drug Metabolism; 10 Enzyme-Activated Prodrug Strategies for Site-Selective Drug Delivery; 11 Prodrug Approaches for Central Nervous System Delivery; 12 Directed Enzyme Prodrug Therapies; Part Three: Codrugs and Soft Drugs; 13 Improving the Use of Drug Combinations Through the Codrug Approach; 14 Soft Drugs; Part Four: Preclinical and Clinical Consideration for Prodrugs15 Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development16 The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs; IndexThis topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.Methods and principles in medicinal chemistry ;v. 47.ProdrugsElectronic books.Prodrugs.615.19615.191Rautio Jarkko918239MiAaPQMiAaPQMiAaPQBOOK9910140873003321Prodrugs and targeted delivery2058877UNINA01081nam0 22002771i 450 UON0040869120231205104730.56120120420d1976 |0itac50 barumRO|||| 1||||Biserica domneasca din Curtea de ArgesMaria Ana Musicescu, Grigore IonescuBucurestiEditura Meridiane197652 p.ill., tav.26 cm.ARTE ROMENA SACRAUONC081676FIROBucureştiUONL000071723.1Architettura medievale21MUSICESCUAna MariaUONV209221708531IONESCUGrigoreUONV208825483895Editura MeridianeUONV262442650ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00408691SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI FONDO ONCIULESCU H 0116 SI LO 8293 5 0116 Biserica domneasca din Curtea de Arges1341981UNIOR01229nam0 22002771i 450 UON0007793020231205102418.69920020107d1898 |0itac50 bafreFR|||| |||||ˆL'‰Atlas marocain d'après les documents originauxpar Paul SchnellTraduit avec l'autorisation de l'auteur par A. Bernardx316 p., p. di tav. ; 25 cmdata inesattaIT-UONSI B Afr4/0474001UON000661992001 Publications de l'Ecole des Lettres d'AlgerBulletin de correspondance africaine21MAROCCODescrizioniUONC021150FIFRParisUONL002984916.4DESCRIZIONI DEL MAROCCO21SCHNELLPaulUONV051158660692Librairie Ernest LerouxUONV247871650ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00077930SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI B Afr 4 0474 SI MR 29905 7 0474 data inesattaAtlas marocain d'après les documents originaux1300098UNIOR